SULINDAC SULFONE

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Product Name: SULINDAC SULFONE
CAS No.: 59864-04-9
Chemical Name: SULINDAC SULFONE
Synonyms: FGN-1;APTOSYN;EXISULIND;SULINDAC SULFONE;Sulindac Impurity 9;Sulindac EP Impurity B;Sulindac sulfone (Exisulind);Sulindac sulfone,Aldose Reductase,inhibit,Exisulind,Inhibitor;(Z)-5-FLUORO-2-METHYL-1[P-(METHYLSULFONYL)BENZYLIDENE]INDENE-3-ACETIC ACID;5-Fluoro-2-methy L-1-((4-(methylsulfonyl)phenyl)methylene)-1H-indene-3-acetic acid
CBNumber: CB6699783
Molecular Formula: C20H17FO4S
Formula Weight: 372.41
MOL File: 59864-04-9.mol

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SULINDAC SULFONE Property

Melting point:: 201～203℃
storage temp.: RT
solubility: DMSO: >25 mg/mL
form: solid
color: yellow
Stability:: Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 week.

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Safety

WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: S1438
Product name: Sulindac sulfone
Purity: ≥94% (HPLC), (solid or powder)
Packaging: 25mg
Price: $461
Updated: 2024/03/01

Sigma-Aldrich

Product number: S1438
Product name: Sulindac sulfone
Purity: ≥94% (HPLC), (solid or powder)
Packaging: 5mg
Price: $120
Updated: 2023/06/20

Cayman Chemical

Product number: 16805
Product name: Sulindac sulfone
Purity: ≥98%
Packaging: 5mg
Price: $46
Updated: 2024/03/01

Cayman Chemical

Product number: 16805
Product name: Sulindac sulfone
Purity: ≥98%
Packaging: 1mg
Price: $31
Updated: 2023/06/20

Cayman Chemical

Product number: 16805
Product name: Sulindac sulfone
Purity: ≥98%
Packaging: 10mg
Price: $88
Updated: 2024/03/01

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SULINDAC SULFONE Chemical Properties,Usage,Production

Description

Sulindac sulfone (59864-04-9) is a metabolite of the cyclooxygenase inhibitor sulindac that induces apoptosis via inhibition of type 5 phosphodiesterases.1 Sulindac sulfone does not inhibit cyclooxygenase at physiological concentrations but does inhibit K-ras-dependent cyclooxygenase-2 expression in colon cancer cells.2 Modulates beta-catenin mediated effects. 3

Uses

Sulindac Sulfone is an inhibitor of growth and inducer of apoptosis in cancer cell lines.

Biochem/physiol Actions

Sulindac sulfone is non-steroidal anti-inflammatory drug and an analgesic that has antiproliferative and apoptotic effects. It inhibits the expression and activity of cyclooxygenase-2 in human colon cancer cells1,2 and reduces tumor burden in adenomatous polyposis patients.3

in vitro

sulindac sulfone treatment also inhibited pge2 production by hca-7 cells with an ic50 of 360 mmol/l. sulindac sulfone at 100 mmol/l reduced 6-ketopgfα by 29.2%. sulindac sulfone reduced the colony number of hca-7 and hct-116 with an ec50 of 50 mmol/l[1]. sulindac sulfone significantly decreased the expression of total cellular β-catenin (50% of control), pro-caspase 3 (49%), cyclin d1 (51%), and pparδ (65%) in sw480 cells. no significant alteration in pro-caspase 3 or β-catenin expression was found in hca7, ls174, or caco-2 cells treated with sulindac sulfone. a dose-dependent reduction in tcf-mediated transcriptional activity was also observed in sw480 cells [2].

in vivo

sulindac sulfone is capable of reducing the incidence, multiplicity and tumor burden in the azoxymethane aom rat model of colorectal cancer. sulindac sulfone had no effect on the growth of hca-7, hct-116 xenografts and cancer cell xenografts [1].

References

References/Citations 1) Thompson et al. (2000) Exisulind induction of apoptosis involves guanosine 3′,5′-cyclic monophosphate phosphodiesterase inhibition, protein kinase G activation and attenuated beta-catenin. Cancer Res., 60 3338 2) Taylor et al. (2000) Sulindac sulfone inhibits K-ras-dependent cyclooxygenase-2 expression in human colon cancer cells; Cancer Res. 60 6607 3) Bravi et al. (2015) Sulindac metabolites decrease cerebrovascular malformations in CCM-3 knockout mice; Proc. Natl. Acad. Sci. USA 112 8421

SULINDAC SULFONE Preparation Products And Raw materials

Raw materials

Preparation Products

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SULINDAC SULFONE Suppliers

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59864-04-9, SULINDAC SULFONERelated Search:

TYRPHOSTIN AG 879 (E)-3-[[[3-[2-(7-CHLORO-2-QUINOLINYL)ETHENYL]PHENYL]-[[(3-DIMETHYLAMINO)-3-OXOPROPYL]THIO]METHYL]THIO]-PROPANOIC ACID, SODIUM SALT 17-AAG SU 4312 SULINDAC SULFONE SULINDAC SULFONE--N/H SULINDAC SULFONE(RG) SULINDAC SULFONE SULINDAC SULFONE 5-FLUORO-1H-INDENE 3-ETHYLINDENE Sulindac 4-FLUORO-2-METHYL-1-VINYL-BENZENE 1-FLUORO-4-((E)-STYRYL)-BENZENE (5-Fluoro-2-methyl-1H-inden-3-yl)acetic acid

SULINDAC SULFONE

(Z)-5-FLUORO-2-METHYL-1[P-(METHYLSULFONYL)BENZYLIDENE]INDENE-3-ACETIC ACID

APTOSYN

EXISULIND

FGN-1

1H-Indene-3-acetic acid, 5-fluoro-2-methy L-1-((4-(methylsulfonyl)phenyl)methylene)-

5-Fluoro-2-methy L-1-((4-(methylsulfonyl)phenyl)methylene)-1H-indene-3-acetic acid

2-[(3Z)-6-Fluoro-2-Methyl-3-[(4-Methylsulfonylphenyl)Methylene]-1-Indenyl]Acetic Acid

Sulindac EP Impurity B

Sulindac sulfone,Aldose Reductase,inhibit,Exisulind,Inhibitor

Sulindac Impurity 9

Sulindac sulfone (Exisulind)

59864-04-9

Antitumor Agents

Cancer Research

BioChemical

Enzyme Inhibitors