7,3',4'-TRIHYDROXYFLAVANONE
- Product Name
- 7,3',4'-TRIHYDROXYFLAVANONE
- CAS No.
- 21913-99-5
- Chemical Name
- 7,3',4'-TRIHYDROXYFLAVANONE
- Synonyms
- BUTIN;7,3',4'-TRIHYDROXYFLAVANONE;3',4',7-trihydroxyflavanone;4H-1-Benzopyran-4-one, 2-(3,4-dihydroxyphenyl)-2,3-dihydro-7-hydroxy-
- CBNumber
- CB6701532
- Molecular Formula
- C15H12O5
- Formula Weight
- 272.25
- MOL File
- Mol file
7,3',4'-TRIHYDROXYFLAVANONE Property
- Boiling point:
- 582.4±50.0 °C(Predicted)
- Density
- 1.485±0.06 g/cm3(Predicted)
- solubility
- Acetonitrile: Soluble
Methanol: Soluble - form
- Solid
- pka
- 7.69±0.40(Predicted)
- color
- Light yellow to light brown
N-Bromosuccinimide Price
- Product number
- 361759
- Product name
- Butin
- Packaging
- 10mg
- Price
- $765
- Updated
- 2021/12/16
- Product number
- CS-0106898
- Product name
- Butin
- Packaging
- 25mg
- Price
- $850
- Updated
- 2021/12/16
- Product number
- CS-0106898
- Product name
- Butin
- Packaging
- 50mg
- Price
- $1350
- Updated
- 2021/12/16
- Product number
- CS-0106898
- Product name
- Butin
- Packaging
- 100mg
- Price
- $1950
- Updated
- 2021/12/16
- Product number
- CS-0106898
- Product name
- Butin
- Packaging
- 5mg
- Price
- $250
- Updated
- 2021/12/16
7,3',4'-TRIHYDROXYFLAVANONE Chemical Properties,Usage,Production
Uses
Butin is a major biologically active flavonoid isolated from the heartwood of Dalbergia odorifera with oral activity, with strong antioxidant, antiplatelet and anti-inflammatory activities. Butin significantly alleviates myocardial infarction and improves heart function, together with prevents diabetes-induced cardiac oxidative damage in rat[1][2].
Definition
ChEBI: 2-(3,4-dihydroxyphenyl)-7-hydroxy-3,4-dihydro-2H-1-benzopyran-4-one is a member of flavanones.
in vivo
Butin (10-40 mg/kg, orally, twice a day, 15 days) can significantly reduce myocardial ischemia-reperfusion injury in diabetic mice, improve heart function, and increase the ability to resist oxidative stress[1].
Butin (25-50 mg/kg, intraperitoneal injection, single dose) can reduce behavioral changes and neuronal conditions in rats with cerebral hemorrhage by reducing apoptosis and inflammatory responses[2].
| Animal Model: | C57/BL6J mice induced by STZ(HY-13753)[1] |
| Dosage: | 10, 20, 40 mg/kg; twice a day; 15 days |
| Administration: | Oral |
| Result: | Improved cardiac function, significant increases in LVSP, +dP/dtmax and -dP/dtmin, reduced myocardial infarction area, reduced caspase-3 activity and Bax/Bcl-2 ratio, reduced GSH-px, GSH, SOD, CAT and GR activity. |
| Animal Model: | Intracerebral hemorrhage rats[2] |
| Dosage: | 25, 50 mg/kg; single dose |
| Administration: | Intraperitoneal injection (i.p.) |
| Result: | Increased the neurological score, significantly reduced the volume of hemorrhagic lesions, significantly reduced the Bax/Bcl-2 ratio and caspase-3 protein expression, and significantly reduced brain tissue inflammatory mediators tumor necrosis factor-α (TNF-α) and interleukin. Reduced levels of 6 (IL-6). |
References
[1] Duan J, et al. Protective effect of butin against ischemia/reperfusion-induced myocardial injury in diabetic mice: involvement of the AMPK/GSK-3β/Nrf2 signaling pathway. Sci Rep. 2017 Jan 27;7:41491. DOI:10.1038/srep41491
[2] Li P, et al. Butin Attenuates Brain Edema in a Rat Model of Intracerebral Hemorrhage by Anti Inflammatory Pathway. Transl Neurosci. 2018 May 8;9:7-12. DOI:10.1515/tnsci-2018-0002
[3] JINPENG LV . Synthesis and melanogenesis evaluation of 3′,4′,7-trihydroxyflavanone derivatives and characterization of flavanone–BODIPY[J]. Bioorganic & Medicinal Chemistry Letters, 2015, 25 7: Pages 1607-1610. DOI: 10.1016/j.bmcl.2015.01.072
[4] S. MILOSAVLJEVIC. Flavonoids of the Heartwood of Cotinus coggygria Scop. Showing Protective Effect on Human Lymphocyte DNA[J]. Natural Product Communications, 2021, 53 1. DOI: 10.1177/1934578x211067289
[5] BHARGAVA S K. Estrogenic and postcoital anticonceptive activity in rats of butin isolated from Butea monosperma seed[J]. Journal of ethnopharmacology, 1986, 18 1: Pages 95-101. DOI: 10.1016/0378-8741(86)90046-2
7,3',4'-TRIHYDROXYFLAVANONE Preparation Products And Raw materials
Raw materials
Preparation Products
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