IKD-8344
- Product Name
- IKD-8344
- CAS No.
- 129046-69-1
- Chemical Name
- IKD-8344
- Synonyms
- IKD-8344;(1R,2R,5S,8S,9S,12R,14S,17R,18R,21S,24S,25S,28R,30S)-rel-2,9,18,25-tetramethyl-12,28-bis[(1S)-1-[(2S,5R)-tetrahydro-5-methyl-2-furanyl]ethyl]-11,27,33,34,35,36-hexaoxapentacyclo[28.2.1.15,8.114,17.121,24]hexatriacontane-3,10,19,26-tetrone
- CBNumber
- CB6708728
- Molecular Formula
- C48H76O12
- Formula Weight
- 845.11
- MOL File
- Mol file
IKD-8344 Property
- storage temp.
- Store at -20°C
- solubility
- DMSO: soluble; Ethanol: soluble; Methanol: soluble
- form
- A solid
N-Bromosuccinimide Price
- Product number
- 28194
- Product name
- IKD-8344
- Packaging
- 1mg
- Price
- $364
- Updated
- 2024/03/01
- Product number
- BIBR1143
- Product name
- IKD-8344
- Packaging
- 1mg
- Price
- $338
- Updated
- 2021/12/16
- Product number
- API0025514
- Product name
- IKD-8344
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $496.66
- Updated
- 2021/12/16
IKD-8344 Chemical Properties,Usage,Production
Description
IKD-8344 is a macrocyclic dilactone originally isolated from an actinomycete species and has diverse biological activities, including anticancer, antimicrobial, and anthelmintic properties.1,2,3 It is cytotoxic to L5178Y murine leukemia cells (IC50 = 0.54 ng/ml).1 IKD-8344 inhibits growth of the mycelial form of C. albicans (MIC = 6.25 μg/ml) and potentiates the activity of polymyxin B against the multidrug-resistant pathogenic bacterium B. cenocepacia.2,3 It is active against T. spiralis in vitro and in vivo.1
References
1. Minami, Y., Yoshida, K., Azuma, R., et al. Structure of a novel macrodiolide antibiotic IKD-
2. Hwang, E.I., Yun, B.S., Yeo, W.H., et al. Compound IKD-
3. Loutet, S.A., El-Halfawy, O.M., Jassem, A.N., et al. Identification of synergists that potentiate the action of polymyxin B against Burkholderia cenocepacia Int. J. Antimicrob. Agents 46(4),376-380(2015).
IKD-8344 Preparation Products And Raw materials
Raw materials
Preparation Products
IKD-8344 Suppliers
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- China
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