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IKD-8344

Product Name
IKD-8344
CAS No.
129046-69-1
Chemical Name
IKD-8344
Synonyms
IKD-8344;(1R,2R,5S,8S,9S,12R,14S,17R,18R,21S,24S,25S,28R,30S)-rel-2,9,18,25-tetramethyl-12,28-bis[(1S)-1-[(2S,5R)-tetrahydro-5-methyl-2-furanyl]ethyl]-11,27,33,34,35,36-hexaoxapentacyclo[28.2.1.15,8.114,17.121,24]hexatriacontane-3,10,19,26-tetrone
CBNumber
CB6708728
Molecular Formula
C48H76O12
Formula Weight
845.11
MOL File
Mol file
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IKD-8344 Property

storage temp. 
Store at -20°C
solubility 
DMSO: soluble; Ethanol: soluble; Methanol: soluble
form 
A solid
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical
Product number
28194
Product name
IKD-8344
Packaging
1mg
Price
$364
Updated
2024/03/01
American Custom Chemicals Corporation
Product number
API0025514
Product name
IKD-8344
Purity
95.00%
Packaging
5MG
Price
$496.66
Updated
2021/12/16
Apolloscientific
Product number
BIBR1143
Product name
IKD-8344
Packaging
1mg
Price
$338
Updated
2021/12/16
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IKD-8344 Chemical Properties,Usage,Production

Description

IKD-8344 is a macrocyclic dilactone originally isolated from an actinomycete species and has diverse biological activities, including anticancer, antimicrobial, and anthelmintic properties.1,2,3 It is cytotoxic to L5178Y murine leukemia cells (IC50 = 0.54 ng/ml).1 IKD-8344 inhibits growth of the mycelial form of C. albicans (MIC = 6.25 μg/ml) and potentiates the activity of polymyxin B against the multidrug-resistant pathogenic bacterium B. cenocepacia.2,3 It is active against T. spiralis in vitro and in vivo.1

References

1. Minami, Y., Yoshida, K., Azuma, R., et al. Structure of a novel macrodiolide antibiotic IKD-8344 Tetrahedron Lett. 33(48),7373-7376(1992).
2. Hwang, E.I., Yun, B.S., Yeo, W.H., et al. Compound IKD-8344, a selective growth inhibitor against the mycelial form of Candida albicans, isolated from Streptomyces sp. A6792 J. Microbiol. Biotechnol. 15(4),909-912(2005).
3. Loutet, S.A., El-Halfawy, O.M., Jassem, A.N., et al. Identification of synergists that potentiate the action of polymyxin B against Burkholderia cenocepacia Int. J. Antimicrob. Agents 46(4),376-380(2015).

IKD-8344 Preparation Products And Raw materials

Raw materials

Preparation Products

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IKD-8344 Suppliers

China 3 Germany 1 United Kingdom 1 United States 1 Global 6
Cayman Chemical Company
Tel
--
Fax
--
Email
cayman@caymanchem.com
Country
United States
ProdList
6213
Advantage
81

129046-69-1, IKD-8344Related Search:


  • IKD-8344
  • (1R,2R,5S,8S,9S,12R,14S,17R,18R,21S,24S,25S,28R,30S)-rel-2,9,18,25-tetramethyl-12,28-bis[(1S)-1-[(2S,5R)-tetrahydro-5-methyl-2-furanyl]ethyl]-11,27,33,34,35,36-hexaoxapentacyclo[28.2.1.15,8.114,17.121,24]hexatriacontane-3,10,19,26-tetrone
  • 129046-69-1