ChemicalBook > CAS DataBase List > 2-BROMOBENZO[B]THIOPHENE

2-BROMOBENZO[B]THIOPHENE

Product Name
2-BROMOBENZO[B]THIOPHENE
CAS No.
5394-13-8
Chemical Name
2-BROMOBENZO[B]THIOPHENE
Synonyms
NSC 2939;NSC 9008;NSC 43552;2-Bromothianaphthene;2-Bromobenzothiophene;2-BROMO-1-BENZOTHIOPHENE;2-BROMOBENZO[B]THIOPHENE;2-Bromobenzothiophene 97%;Benzo[b]thiophene, 2-broMo-;2-Bromobenzo[b]thiophene 97%
CBNumber
CB6709169
Molecular Formula
C8H5BrS
Formula Weight
213.1
MOL File
5394-13-8.mol
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2-BROMOBENZO[B]THIOPHENE Property

Melting point:
44.5-45℃
Boiling point:
284.7±13.0 °C(Predicted)
Density 
1.649±0.06 g/cm3(Predicted)
Flash point:
>110℃
storage temp. 
under inert gas (nitrogen or Argon) at 2–8 °C
form 
solid
color 
White
InChI
InChI=1S/C8H5BrS/c9-8-5-6-3-1-2-4-7(6)10-8/h1-5H
InChIKey
WIFMYMXKTAVDSQ-UHFFFAOYSA-N
SMILES
C1(Br)SC2=CC=CC=C2C=1
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Safety

Hazard Codes 
Xn
Risk Statements 
20/21/22-36/37/38-36-22
Safety Statements 
22-26-36/37/39
WGK Germany 
3
Hazard Note 
Harmful
HS Code 
29349990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P337+P313IF eye irritation persists: Get medical advice/attention.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
761761
Product name
2-Bromobenzothiophene
Purity
97%
Packaging
1g
Price
$60.9
Updated
2025/07/31
TRC
Product number
B680648
Product name
2-Bromobenzo[b]thiophene
Packaging
500mg
Price
$85
Updated
2021/12/16
TRC
Product number
B680648
Product name
2-Bromobenzo[b]thiophene
Packaging
2.5g
Price
$215
Updated
2021/12/16
Apolloscientific
Product number
OR9631
Product name
2-Bromobenzo[b]thiophene
Packaging
25g
Price
$500
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
HCH0018846
Product name
2-BROMOBENZO[B]THIOPHENE
Purity
95.00%
Packaging
250MG
Price
$613.88
Updated
2021/12/16
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2-BROMOBENZO[B]THIOPHENE Chemical Properties,Usage,Production

Chemical Properties

White solid

Uses

2-Bromobenzo[b]thiophene is used in the stereoselective preparation of halogenated benzoxazines via enantioselective halocyclization of o-anilidostyrenes using chiral anion phase-transfer catalysts.

Synthesis

95-15-8

5394-13-8

To a solution of benzo[b]thiophene (2.0 g, 15 mmol) in tetrahydrofuran (20 mL) was slowly added n-butyllithium (2.5 M hexane solution, 12 mL, 30 mmol) dropwise at -70 °C and under nitrogen protection. The reaction mixture was stirred continuously at this temperature for 30 minutes. Subsequently, N-bromosuccinimide (5.3 g, 30 mmol) was added and the reaction system was slowly warmed from -70 °C to room temperature over 1 hour. Upon completion of the reaction, the reaction was quenched with saturated aqueous ammonium chloride solution (20 mL) followed by extraction with ethyl acetate (3 x 30 mL). The organic phases were combined, concentrated in vacuum, and the residue was purified by silica gel column chromatography [eluent: petroleum ether/ethyl acetate = 100:1] to afford 2-bromobenzothiophene (0.50 g, 16% yield) as a white solid.

References

[1] Patent: WO2006/56418, 2006, A2. Location in patent: Page/Page column 68-69
[2] Chemistry - An Asian Journal, 2014, vol. 9, # 9, p. 2542 - 2547,6
[3] Bioorganic and Medicinal Chemistry Letters, 2006, vol. 16, # 11, p. 3034 - 3038
[4] Patent: WO2017/69980, 2017, A1. Location in patent: Paragraph 00274; 00275
[5] Journal of the American Chemical Society, 1952, vol. 74, p. 664

2-BROMOBENZO[B]THIOPHENE Preparation Products And Raw materials

Raw materials

Preparation Products

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2-BROMOBENZO[B]THIOPHENE Suppliers

Belgium 1 China 124 Germany 1 India 2 United Kingdom 2 United States 10 Global 140
Shanghai Wuping Biological Technology Co., Ltd.
Tel
18501609135
Fax
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Email
182517690@qq.com
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China
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219
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J & K SCIENTIFIC LTD.
Tel
18210857532; 18210857532
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
96815
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76
Energy Chemical
Tel
021-021-58432009 400-005-6266
Fax
021-58436166
Email
sales8178@energy-chemical.com
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China
ProdList
44801
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61
Shanghai Yuanding Chem. Sci. & Tech. Co., Ltd.
Tel
21-57721279
Fax
QQ：14057904
Email
sales@shydchem.com.cn
Country
China
ProdList
998
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56
Adamas Reagent, Ltd.
Tel
400-6009262 16621234537
Fax
021-64823266
Email
chenyj@titansci.com
Country
China
ProdList
14101
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59
Nanjing Chemlin Chemical Co., Ltd
Tel
025-83697070
Fax
+86-25-83453306
Email
info@chemlin.com.cn
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China
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15883
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64
Shandong Xiya Chemical Co., Ltd
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4009903999 13355009207
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0539-6365991
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3007715519@qq.com
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China
ProdList
18729
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57
Springchem New Material Technology Co.,Limited
Tel
+86-021-62885108 +8613917661608
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info@spring-chem.com
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China
ProdList
2068
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57
T&W GROUP
Tel
021-61551611 13296011611
Fax
＋86 21-50676805
Email
contact@trustwe.com
Country
China
ProdList
9895
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Hangzhou Sage Chemical Co., Ltd.
Tel
+86057186818502 13588463833
Fax
Pls mail us for more information!
Email
info@sagechem.com
Country
China
ProdList
10266
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View Lastest Price from 2-BROMOBENZO[B]THIOPHENE manufacturers

Henan Aochuang Chemical Co.,Ltd.
Product
2-BROMOBENZO[B]THIOPHENE 5394-13-8
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
98%
Supply Ability
1ton
Release date
2022-09-27
Career Henan Chemical Co
Product
2-BROMOBENZO[B]THIOPHENE 5394-13-8
Price
US $1.00/g
Min. Order
1g
Purity
99%
Supply Ability
g/kg/T
Release date
2019-12-18

5394-13-8, 2-BROMOBENZO[B]THIOPHENERelated Search:

2-BROMO-5-CHLORO-3-METHYLBENZO[B]THIOPHENE 3-BROMOBENZO[B]THIOPHENE 5-BROMOBENZO[B]THIOPHENE-3-CARBONYL CHLORIDE 5-BROMOBENZO[B]THIOPHENE-3-CARBOXYLIC ACID,5-Bromobenzo[b]thiophene-3-carboxylic acid 97+% 5-Bromobenzo[c]thiophene 5-Bromobenzo[b]thiophene 5-BROMOBENZO[B]THIOPHENE-2-BORONIC ACID 2-BROMOBENZO[B]THIOPHENE 2-BROMO-3-METHYL-BENZO[B]THIOPHENE 2-BROMO-5-CHLORO-1-BENZOTHIOPHENE-3-CARBALDEHYDE 2,3-Dibromobenzo[b]thiophene 2-BROMO-5-METHYL-1-BENZOTHIOPHENE 5-BROMOBENZO[B]THIOPHENE-3-ACETONITRILE 5-BROMOBENZO[B]THIOPHENE-2-CARBALDEHYDE 2-AMINO-6-BROMOBENZO[B]THIOPHENE-3-CARBONITRILE 5-BROMOBENZO[B]THIOPHENE-2-CARBONITRILE Methyl 3-amino-6-bromobenzo[b]thiophene-2-carboxylate 5-BROMOBENZO[B]THIOPHENE-3-CARBALDEHYDE,5-BROMOBENZO[B]THIOPHENE-3-CARBOXALDEHYDE,5-Bromobenzo[b]thiophene-3-carboxaldehyde 97%

  • 2-Bromobenzothiophene
  • 2-Bromothianaphthene
  • NSC 2939
  • NSC 43552
  • NSC 9008
  • 2-Bromobenzothiophene 97%
  • 2-Bromobenzothiophene, >=96%
  • Benzo[b]thiophene, 2-broMo-
  • 2-BROMOBENZO[B]THIOPHENE
  • 2-Bromobenzo[b]thiophene 97%
  • 2-BROMO-1-BENZOTHIOPHENE
  • 2-BROMOBENZO[B]THIOPHENE ISO 9001：2015 REACH
  • 2-Bromobenzothiophene in isooctane
  • 5394-13-8