[(PF)PHE4]NOCICEPTIN(1-13)NH2

Product Name: [(PF)PHE4]NOCICEPTIN(1-13)NH2
CAS No.: 380620-88-2
Chemical Name: [(PF)PHE4]NOCICEPTIN(1-13)NH2
Synonyms: M.W. 1399.60 C61H99FN22O15;[(PF)PHE4]NOCICEPTIN(1-13)NH2;PHE-GLY-GLY-PFLUOROPHE-THR-GLY-ALA-ARG-LYS-SER-ALA-ARG-LYS-NH2;L-Lysinamide, L-phenylalanylglycylglycyl-4-fluoro-L-phenylalanyl-L-threonylglycyl-L-alanyl-L-arginyl-L-lysyl-L-seryl-L-alanyl-L-arginyl- (9CI)
CBNumber: CB6711333
Molecular Formula: C61H99FN22O15
Formula Weight: 1399.58
MOL File: 380620-88-2.mol

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[(PF)PHE4]NOCICEPTIN(1-13)NH2 Property

Density: 1.47±0.1 g/cm3(Predicted)
storage temp.: Desiccate at -20°C
form: Powder
pka: 12.91±0.46(Predicted)
Water Solubility: Soluble to 2 mg/ml in water
Sequence: H-Phe-Gly-Gly-Phe(4-F)-Thr-Gly-Ala-Arg-Lys-Ser-Ala-Arg-Lys-NH2

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: P998443
Product name: [(pF)Phe4]Nociceptin(1-13)NH2
Packaging: 1mg
Price: $220
Updated: 2021/12/16

ApexBio Technology

Product number: B5131
Product name: [(pF)Phe4]Nociceptin(1-13)NH2
Packaging: 1mg
Price: $345
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: BIO0000255
Product name: [(PF)PHE4]N/OFQ(1-13)NH2
Purity: 95.00%
Packaging: 5MG
Price: $505.16
Updated: 2021/12/16

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[(PF)PHE4]NOCICEPTIN(1-13)NH2 Chemical Properties,Usage,Production

Uses

[(pF)Phe4]Nociceptin(1-13)NH2 is a highly potent and selective NOP receptor (OP4) agonist, with a pKi of 10.68 and a pEC50 of 9.31. [(pF)Phe4]Nociceptin(1-13)NH2 displays high selectivity over δ, κ, and μ opioid receptors (>3000 fold)[1][2].

in vivo

In unanaesthetised normotensive mice, bolus intravenous injection of 100 nmol/kg of [(pF)Phe4]Nociceptin(1-13)NH2 decreases mean blood pressure and heart rate; these effects are longer lasting than those elicited by the same dose of NC(1-13)NH2. I.c.v. administration of [(pF)Phe4]Nociceptin(1-13)NH2 dose-dependently stimulated feeding in rats, and is about tenfold more potent than NC(1-13)NH2^[2].

References

[1] Rizzi A, et al. Pharmacological characterisation of [(pX)Phe4]nociceptin(1-13)NH2 analogues. 2. In vivo studies. Naunyn Schmiedebergs Arch Pharmacol. 2002;365(6):450-456. DOI:10.1007/s00210-002-0549-7
[2] Bigoni R, et al. Pharmacological characterisation of [(pX)Phe4]nociceptin(1-13)amide analogues. 1. In vitro studies. Naunyn Schmiedebergs Arch Pharmacol. 2002;365(6):442-449. DOI:10.1007/s00210-002-0548-8
[3] Guerrini R, et al. Structure-activity studies of the Phe(4) residue of nociceptin(1-13)-NH(2): identification of highly potent agonists of the nociceptin/orphanin FQ receptor. J Med Chem. 2001;44(23):3956-3964. DOI:10.1021/jm010221v

[(PF)PHE4]NOCICEPTIN(1-13)NH2 Preparation Products And Raw materials

Raw materials

Preparation Products

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[(PF)PHE4]NOCICEPTIN(1-13)NH2 Suppliers

China 26 France 1 Germany 2 Japan 1 United Kingdom 1 United States 3 Global 34

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380620-88-2, [(PF)PHE4]NOCICEPTIN(1-13)NH2Related Search:

PHE-GLY-GLY 3-PENTAFLUOROPHENYL-PROPIONALDEHYDE NOCICEPTIN (1-13) AMIDE [(PF)PHE4]NOCICEPTIN(1-13)NH2 3-(2,4,6-TRIFLUORO-PHENYL)-PROPIONALDEHYDE

[(PF)PHE4]NOCICEPTIN(1-13)NH2

PHE-GLY-GLY-PFLUOROPHE-THR-GLY-ALA-ARG-LYS-SER-ALA-ARG-LYS-NH2

M.W. 1399.60 C61H99FN22O15

L-Lysinamide, L-phenylalanylglycylglycyl-4-fluoro-L-phenylalanyl-L-threonylglycyl-L-alanyl-L-arginyl-L-lysyl-L-seryl-L-alanyl-L-arginyl- (9CI)

380620-88-2

C61H99FN22O15

C61H95F5N22O15

Opioid receptor and opioid-like receptor