[(PF)PHE4]NOCICEPTIN(1-13)NH2
- Product Name
- [(PF)PHE4]NOCICEPTIN(1-13)NH2
- CAS No.
- 380620-88-2
- Chemical Name
- [(PF)PHE4]NOCICEPTIN(1-13)NH2
- Synonyms
- M.W. 1399.60 C61H99FN22O15;[(PF)PHE4]NOCICEPTIN(1-13)NH2;PHE-GLY-GLY-PFLUOROPHE-THR-GLY-ALA-ARG-LYS-SER-ALA-ARG-LYS-NH2;L-Lysinamide, L-phenylalanylglycylglycyl-4-fluoro-L-phenylalanyl-L-threonylglycyl-L-alanyl-L-arginyl-L-lysyl-L-seryl-L-alanyl-L-arginyl- (9CI)
- CBNumber
- CB6711333
- Molecular Formula
- C61H99FN22O15
- Formula Weight
- 1399.58
- MOL File
- 380620-88-2.mol
[(PF)PHE4]NOCICEPTIN(1-13)NH2 Property
- Density
- 1.47±0.1 g/cm3(Predicted)
- storage temp.
- Desiccate at -20°C
- form
- Powder
- pka
- 12.91±0.46(Predicted)
- Water Solubility
- Soluble to 2 mg/ml in water
- Sequence
- H-Phe-Gly-Gly-Phe(4-F)-Thr-Gly-Ala-Arg-Lys-Ser-Ala-Arg-Lys-NH2
N-Bromosuccinimide Price
- Product number
- P998443
- Product name
- [(pF)Phe4]Nociceptin(1-13)NH2
- Packaging
- 1mg
- Price
- $220
- Updated
- 2021/12/16
- Product number
- B5131
- Product name
- [(pF)Phe4]Nociceptin(1-13)NH2
- Packaging
- 1mg
- Price
- $345
- Updated
- 2021/12/16
- Product number
- BIO0000255
- Product name
- [(PF)PHE4]N/OFQ(1-13)NH2
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $505.16
- Updated
- 2021/12/16
[(PF)PHE4]NOCICEPTIN(1-13)NH2 Chemical Properties,Usage,Production
Uses
[(pF)Phe4]Nociceptin(1-13)NH2 is a highly potent and selective NOP receptor (OP4) agonist, with a pKi of 10.68 and a pEC50 of 9.31. [(pF)Phe4]Nociceptin(1-13)NH2 displays high selectivity over δ, κ, and μ opioid receptors (>3000 fold)[1][2].
in vivo
In unanaesthetised normotensive mice, bolus intravenous injection of 100 nmol/kg of [(pF)Phe4]Nociceptin(1-13)NH2 decreases mean blood pressure and heart rate; these effects are longer lasting than those elicited by the same dose of NC(1-13)NH2. I.c.v. administration of [(pF)Phe4]Nociceptin(1-13)NH2 dose-dependently stimulated feeding in rats, and is about tenfold more potent than NC(1-13)NH2[2].
References
[1] Rizzi A, et al. Pharmacological characterisation of [(pX)Phe4]nociceptin(1-13)NH2 analogues. 2. In vivo studies. Naunyn Schmiedebergs Arch Pharmacol. 2002;365(6):450-456. DOI:10.1007/s00210-002-0549-7
[2] Bigoni R, et al. Pharmacological characterisation of [(pX)Phe4]nociceptin(1-13)amide analogues. 1. In vitro studies. Naunyn Schmiedebergs Arch Pharmacol. 2002;365(6):442-449. DOI:10.1007/s00210-002-0548-8
[3] Guerrini R, et al. Structure-activity studies of the Phe(4) residue of nociceptin(1-13)-NH(2): identification of highly potent agonists of the nociceptin/orphanin FQ receptor. J Med Chem. 2001;44(23):3956-3964. DOI:10.1021/jm010221v
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