4-(TERT-BUTOXYCARBONYL)BENZOIC ACID
- Product Name
- 4-(TERT-BUTOXYCARBONYL)BENZOIC ACID
- CAS No.
- 20576-82-3
- Chemical Name
- 4-(TERT-BUTOXYCARBONYL)BENZOIC ACID
- Synonyms
- tert-Butyl terephthalate;mono-(tert-Butyl) terephthalate;tert-Butyl hydrogen terephthalate;4-(TERT-BUTOXYCARBONYL)BENZOIC ACID;TEREPHALIC ACID MONO TERT-BUTYL ESTER;1-(1,1-Dimethylethyl) 1,4-benzenedicarboxylate;4-[(2-methylpropan-2-yl)oxycarbonyl]benzoic Acid;4-[(2-methylpropan-2-yl)oxy-oxomethyl]benzoic acid;1,4-Benzenedicarboxylic acid, 1-(1,1-dimethylethyl) ester;4-(tert-Butoxycarbonyl)benzoic acid, tert-Butyl 4-carboxybenzoate
- CBNumber
- CB6722676
- Molecular Formula
- C12H14O4
- Formula Weight
- 222.24
- MOL File
- 20576-82-3.mol
4-(TERT-BUTOXYCARBONYL)BENZOIC ACID Property
- Melting point:
- 209-212(dec.)
- Boiling point:
- 351.8±25.0 °C(Predicted)
- Density
- 1.173±0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- solubility
- DMSO (Slightly), Ethyl Acetate (Slightly). Methanol (Slightly)
- pka
- 3.76±0.10(Predicted)
- form
- Solid
- color
- White to Off-White
Safety
- Hazard Codes
- Xi
- Hazard Note
- Irritant
- HS Code
- 2918300090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 165008
- Product name
- Mono-tert-Butyl Terephthalate
- Packaging
- 1g
- Price
- $460
- Updated
- 2021/12/16
- Product number
- B809505
- Product name
- Mono-tert-ButylTerephthalate
- Packaging
- 10g
- Price
- $1135
- Updated
- 2021/12/16
- Product number
- Z1787
- Product name
- 4-(tert-Butoxycarbonyl)benzoicacid
- Packaging
- 250mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- 009281
- Product name
- 4-(tert-Butoxycarbonyl)benzoic acid
- Packaging
- 1g
- Price
- $81
- Updated
- 2021/12/16
- Product number
- 2623-1-Y4
- Product name
- mono-(tert-Butyl) terephthalate
- Packaging
- 1g
- Price
- $156
- Updated
- 2021/12/16
4-(TERT-BUTOXYCARBONYL)BENZOIC ACID Chemical Properties,Usage,Production
Uses
Mono-tert-Butyl Terephthalate, is used in the synthesis of pyrrolidinone analogs acting as potential 20S proteasome inhibitors.
Synthesis
28313-42-0
20576-82-3
The general procedure for the synthesis of 4-(tert-butoxycarbonyl)benzoic acid from di-tert-butyl terephthalate was as follows: 6.1 g (0.022 mol) of di-tert-butyl terephthalate was suspended in 30 mL of tert-butanol, and 22 mL (0.022 mol) of 1N KOH solution was slowly added. The reaction mixture was heated to 60°C and maintained at this temperature for 7-8 hours. After completion of the reaction, the mixture was cooled, diluted with water and extracted three times with ethyl acetate. After combining the organic phases, the aqueous phase was acidified to acidity with dilute hydrochloric acid and the product was again extracted with ethyl acetate. All ethyl acetate extracts were combined, washed with saturated aqueous sodium chloride solution and dried over anhydrous magnesium sulfate. The desiccant was removed by filtration, and the filtrate was concentrated under reduced pressure to give 4-(tert-butoxycarbonyl)benzoic acid (mono-tert-butyl terephthalate) as a white solid with a yield of 4.7 g, 96% yield, and a melting point of 100-102°C. The product was extracted with dilute hydrochloric acid.
References
[1] Journal of Medicinal Chemistry, 1992, vol. 35, # 4, p. 641 - 662
[2] Patent: US5221665, 1993, A
[3] Patent: US5232928, 1993, A
[4] Patent: EP369391, 1991, A3
[5] Patent: EP369391, 1990, A2
4-(TERT-BUTOXYCARBONYL)BENZOIC ACID Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 4-(TERT-BUTOXYCARBONYL)BENZOIC ACID manufacturers
- Product
- 4-[(2-methylpropan-2-yl)oxycarbonyl]benzoicacid 20576-82-3
- Price
- US $0.00/KG
- Min. Order
- 1KG
- Purity
- 98.6%
- Supply Ability
- 100 tons
- Release date
- 2022-01-14
- Product
- 4-(TERT-BUTOXYCARBONYL)BENZOIC ACID 20576-82-3
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 200kg
- Release date
- 2019-12-31