ChemicalBook > CAS DataBase List > 7,10-Dioxa-2,5-diazaundecanoic acid, 4,9-dioxo-11-phenyl-, 9H-fluoren-9-ylmethyl ester
7,10-Dioxa-2,5-diazaundecanoic acid, 4,9-dioxo-11-phenyl-, 9H-fluoren-9-ylmethyl ester
- Product Name
- 7,10-Dioxa-2,5-diazaundecanoic acid, 4,9-dioxo-11-phenyl-, 9H-fluoren-9-ylmethyl ester
- CAS No.
- 1599440-07-9
- Chemical Name
- 7,10-Dioxa-2,5-diazaundecanoic acid, 4,9-dioxo-11-phenyl-, 9H-fluoren-9-ylmethyl ester
- Synonyms
- Fmoc-Gly-NH-CH2-O-CH2-Cbz;7,10-Dioxa-2,5-diazaundecanoic acid, 4,9-d;Benzyl 2-[[2-(Fmoc-amino)acetamido]methoxy]acetate;benzyl 1-(9H-fluoren-9-yl)-3,6-dioxo-2,9-dioxa-4,7-diazaunde;benzyl 1-(9H-fluoren-9-yl)-3,6-dioxo-2,9-dioxa-4,7-diazaundecan-11-oate;benzyl 2-[(2-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)acetamido)methoxy]acetate;7,10-Dioxa-2,5-diazaundecanoic acid, 4,9-dioxo-11-phenyl-, 9H-fluoren-9-ylmethyl ester
- CBNumber
- CB67247521
- Molecular Formula
- C27H26N2O6
- Formula Weight
- 474.51
- MOL File
- 1599440-07-9.mol
More
Less
7,10-Dioxa-2,5-diazaundecanoic acid, 4,9-dioxo-11-phenyl-, 9H-fluoren-9-ylmethyl ester Property
- Boiling point:
- 733.0±60.0 °C(Predicted)
- Density
- 1.269±0.06 g/cm3(Predicted)
- pka
- 10.58±0.46(Predicted)
- form
- Solid
- color
- White to off-white
More
Less
7,10-Dioxa-2,5-diazaundecanoic acid, 4,9-dioxo-11-phenyl-, 9H-fluoren-9-ylmethyl ester Chemical Properties,Usage,Production
Uses
7,10-Dioxa-2,5-diazaundecanoic acid, 4,9-dioxo-11-phenyl-, 9H-fluoren-9-ylmethyl ester is an important organic intermediate. It can be used to synthesize camptothecin derivatives and other anticancer organic compounds, and then synthesize antibody-drug conjugate.
Definition
7,10-Dioxa-2,5-diazaundecanoic acid, 4,9-dioxo-11-phenyl-, 9H-fluoren-9-ylmethyl ester is also known as Benzyl 1-(9H-fluoren-9-yl)-3,6-dioxo-2,9-dioxa-4,7-diazaundecan-11-oate.
Preparation
(2-((((9H-fluorene-9-yl)methoxy)carbonyl)amino)acetamido)methyl acetate (7.36 g, 20.0 mmol), THF, and p-toluenesulfonic acid monohydrate (0.38 g, 2.00 mmol) were added to a single-neck bottle at 0°C. Benzyl glycolate (6.65 g, 40.0 mmol) was added dropwise and the temperature was naturally raised to room temperature for 2-4h. TLC monitoring this reaction. After the reaction was completed, saturated NaHCO3 solution was added to quench the reaction, extracted with ethyl acetate, and washed with saturated sodium chloride solution. After dried over anhydrous sodium sulfate, filtered, concentrated, and the residue was purified by column chromatography to obtain 7,10-Dioxa-2,5-diazaundecanoic acid, 4,9-dioxo-11-phenyl-, 9H-fluoren-9-ylmethyl ester.
7,10-Dioxa-2,5-diazaundecanoic acid, 4,9-dioxo-11-phenyl-, 9H-fluoren-9-ylmethyl ester Preparation Products And Raw materials
Raw materials
Preparation Products
More
Less
7,10-Dioxa-2,5-diazaundecanoic acid, 4,9-dioxo-11-phenyl-, 9H-fluoren-9-ylmethyl ester Suppliers
- Tel
- 028-82729560 18030702676
- Fax
- 028-82729560
- sales@yuehepharm.com
- Country
- China
- ProdList
- 179
- Advantage
- 58
- Tel
- 0510-83583050 13771062561
- Fax
- 0510-83583039
- willsun@peptide-search.com
- Country
- China
- ProdList
- 6716
- Advantage
- 58
- Tel
- 0571-87213919
- Fax
- 0571-87213919
- Eric@peptidego.com
- Country
- China
- ProdList
- 6756
- Advantage
- 58
- Tel
- 025-84767922 18936879710
- sales@abydoscientific.com
- Country
- China
- ProdList
- 1009
- Advantage
- 58
- Tel
- 19981275275
- sales@zsdbiopharm.com
- Country
- China
- ProdList
- 285
- Advantage
- 58
- Tel
- +86-400-002-6226 +86-13028896684;
- sales@rrkchem.com
- Country
- China
- ProdList
- 57401
- Advantage
- 58
- Tel
- 18621054990
- maychemicals@sina.com
- Country
- China
- ProdList
- 673
- Advantage
- 58
- Tel
- 021-61263377 15023907684
- Fax
- 021-61263399
- 15800684150@163.com
- Country
- China
- ProdList
- 8131
- Advantage
- 58
- Tel
- +1-2135480471 +1-2135480471
- sales@sarms4muscle.com
- Country
- China
- ProdList
- 10473
- Advantage
- 58
- Tel
- +86-021-61263370 +86-18901917034
- Country
- CHINA
- ProdList
- 3904
- Advantage
- 58
- Tel
- 021-58099077-8041 18601625411
- sales@birdotech.com
- Country
- China
- ProdList
- 9365
- Advantage
- 58
- Tel
- 021-61263455 13167021076
- amy@glschina.com
- Country
- China
- ProdList
- 8745
- Advantage
- 58
- Tel
- 18616377689
- nanfengdrug@163.com
- Country
- China
- ProdList
- 20565
- Advantage
- 58
- Tel
- 0510-85629785 18013409632
- Fax
- 0510-85625359
- sales@reading-chemicals.com
- Country
- China
- ProdList
- 14081
- Advantage
- 58
- Tel
- 021-50896099 18017206244
- Fax
- QQ：3268640975
- sales@tekanbio.com
- Country
- China
- ProdList
- 109
- Advantage
- 58
- Tel
- 0371-53736046 13393710386
- Fax
- QQ:2853979814
- 2853979814@qq.com
- Country
- China
- ProdList
- 10000
- Advantage
- 58
- Tel
- 15221533763
- suzhourich@163.com
- Country
- China
- ProdList
- 991
- Advantage
- 58
- Tel
- 15051477682
- changming.pan@csynbio.com
- Country
- China
- ProdList
- 243
- Advantage
- 58
- Tel
- 400-1647117 13681763483
- product02@bidepharm.com
- Country
- China
- ProdList
- 62163
- Advantage
- 58
- Tel
- 028-61715638 18011352545
- Fax
- QQ：1242335375
- 1242335275@qq.com
- Country
- China
- ProdList
- 344
- Advantage
- 58
- Tel
- 0571-87213919 17306812703
- 3007955328@qq.com
- Country
- China
- ProdList
- 6445
- Advantage
- 58
- Tel
- 18626450290
- yftan@aikonchem.com
- Country
- China
- ProdList
- 10715
- Advantage
- 58
- Tel
- 400-400-8210725
- malulu@leyan.com
- Country
- China
- ProdList
- 39953
- Advantage
- 58
- Tel
- 18014456767
- wenxi@jszkhy.com
- Country
- China
- ProdList
- 1349
- Advantage
- 58
- Tel
- 18912729622
- 66161984@qq.com
- Country
- China
- ProdList
- 888
- Advantage
- 58
- Tel
- 13611955358 13611955358
- yanfen2023@126.com
- Country
- China
- ProdList
- 1853
- Advantage
- 58
- Tel
- 021-50795510 4000665055
- syeu@accelachem.com
- Country
- China
- ProdList
- 11710
- Advantage
- 58
- Tel
- 13356310019 13356310019
- boyu2024@163.com
- Country
- China
- ProdList
- 2683
- Advantage
- 58
- Tel
- 025-58906079 17352406906
- sales@bicbiotech.com
- Country
- China
- ProdList
- 7607
- Advantage
- 58
- Tel
- 17360178904 18217049878
- zengzongwen@pegtide.com
- Country
- China
- ProdList
- 1222
- Advantage
- 58
- Tel
- 86-13349903920; 13349903920
- Fax
- -
- 869523959@qq.com
- Country
- China
- ProdList
- 9695
- Advantage
- 58
- Tel
- 13962794339 13962794339
- 3686954964@qq.com
- Country
- China
- ProdList
- 165
- Advantage
- 58
- Tel
- 13472578225 18321033991
- marketing@pharmalego.com
- Country
- China
- ProdList
- 2500
- Advantage
- 58
- Tel
- 13012344321
- 3995296515@qq.com
- Country
- China
- ProdList
- 6898
- Advantage
- 58
- Tel
- +undefined-21-51877795
- Fax
- +86 21 5161 9052/ 5187 7796
- ivan@atkchemical.com
- Country
- China
- ProdList
- 32951
- Advantage
- 60
- Tel
- +8618381337976
- bd@xilinglab.com
- Country
- China
- ProdList
- 86
- Advantage
- 58
- Tel
- +86-0371-63689365 +8618638391208
- sales@aochuangchem.com
- Country
- China
- ProdList
- 9237
- Advantage
- 58
More
Less
View Lastest Price from 7,10-Dioxa-2,5-diazaundecanoic acid, 4,9-dioxo-11-phenyl-, 9H-fluoren-9-ylmethyl ester manufacturers
Henan Aochuang Chemical Co.,Ltd.
- Product
- 7,10-Dioxa-2,5-diazaundecanoic acid, 4,9-dioxo-11-phenyl-, 9H-fluoren-9-ylmethyl ester 1599440-07-9
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 1Ton
- Release date
- 2022-10-13