ChemicalBook > CAS DataBase List > 4-[3-(6-METHYL-2-PYRIDINYL)-1H-PYRAZOL-4-YL]-QUINOLINE

4-[3-(6-METHYL-2-PYRIDINYL)-1H-PYRAZOL-4-YL]-QUINOLINE

Product Name
4-[3-(6-METHYL-2-PYRIDINYL)-1H-PYRAZOL-4-YL]-QUINOLINE
CAS No.
607737-87-1
Chemical Name
4-[3-(6-METHYL-2-PYRIDINYL)-1H-PYRAZOL-4-YL]-QUINOLINE
Synonyms
A77-01;A-77-01;A 77-01;CS-1775;A7701;A 7701; A-7701;A 77-01, 10 mM in DMSO;4-[3-(6-Methylpyridin-2-yl)-1H-pyrazol-4-yl]quinoline;4-[3-(6-METHYL-2-PYRIDINYL)-1H-PYRAZOL-4-YL]-QUINOLINE;4-[5-(6-methylpyridin-2-yl)-1~{H}-pyrazol-4-yl]quinoline;Quinoline, 4-[3-(6-methyl-2-pyridinyl)-1H-pyrazol-4-yl]-
CBNumber
CB6727914
Molecular Formula
C18H14N4
Formula Weight
286.33
MOL File
607737-87-1.mol
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4-[3-(6-METHYL-2-PYRIDINYL)-1H-PYRAZOL-4-YL]-QUINOLINE Property

storage temp. 
Store at -20°C
solubility 
insoluble in H2O; ≥14.3 mg/mL in DMSO; ≥8.84 mg/mL in EtOH with gentle warming and ultrasonic
form 
solid
color 
Off-white to light yellow
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Cayman Chemical
Product number
18396
Product name
A-77-01
Purity
≥98%
Packaging
1mg
Price
$40
Updated
2024/03/01
Cayman Chemical
Product number
18396
Product name
A-77-01
Purity
≥98%
Packaging
5mg
Price
$139
Updated
2024/03/01
Cayman Chemical
Product number
18396
Product name
A-77-01
Purity
≥98%
Packaging
10mg
Price
$236
Updated
2024/03/01
Cayman Chemical
Product number
18396
Product name
A-77-01
Purity
≥98%
Packaging
25mg
Price
$492
Updated
2024/03/01
Tocris
Product number
6712
Product name
A77-01
Purity
≥98%(HPLC)
Packaging
5
Price
$148
Updated
2021/12/16
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4-[3-(6-METHYL-2-PYRIDINYL)-1H-PYRAZOL-4-YL]-QUINOLINE Chemical Properties,Usage,Production

Uses

A 77-01 is a potent inhibitor of transforming growth factor (TGF)-β type I receptor superfamily activin-like kinase ALK5 with an IC50 of 25 nM[1].

storage

Store at +4°C

References

[1] Tojo M, et al. The ALK-5 inhibitor A-83-01 inhibits Smad signaling and epithelial-to-mesenchymal transition by transforming growth factor-beta. Cancer Sci. 2005 Nov;96(11):791-800. DOI:10.1111/j.1349-7006.2005.00103.x

4-[3-(6-METHYL-2-PYRIDINYL)-1H-PYRAZOL-4-YL]-QUINOLINE Preparation Products And Raw materials

Raw materials

Preparation Products

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4-[3-(6-METHYL-2-PYRIDINYL)-1H-PYRAZOL-4-YL]-QUINOLINE Suppliers

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607737-87-1, 4-[3-(6-METHYL-2-PYRIDINYL)-1H-PYRAZOL-4-YL]-QUINOLINERelated Search:

LY-364947 A-83-01 4-[3-(6-METHYL-2-PYRIDINYL)-1H-PYRAZOL-4-YL]-QUINOLINE

  • 4-[3-(6-METHYL-2-PYRIDINYL)-1H-PYRAZOL-4-YL]-QUINOLINE
  • A 77-01
  • A-77-01
  • A77-01
  • 4-[3-(6-Methyl-2-pyridinyl)-1H-pyrazol-4-yl]quinoline A 77-01
  • 4-[3-(6-Methylpyridin-2-yl)-1H-pyrazol-4-yl]quinoline
  • CS-1775
  • 4-[5-(6-methylpyridin-2-yl)-1~{H}-pyrazol-4-yl]quinoline
  • A7701;A 7701; A-7701
  • Quinoline, 4-[3-(6-methyl-2-pyridinyl)-1H-pyrazol-4-yl]-
  • TGF-β Receptor,Transforming growth factor beta receptors,A 77-01,Inhibitor,A 77 01,inhibit,A 7701
  • A 77-01, 10 mM in DMSO
  • 607737-87-1
  • Inhibitors