2-Phenylpiperazine
- Product Name
- 2-Phenylpiperazine
- CAS No.
- 5271-26-1
- Chemical Name
- 2-Phenylpiperazine
- Synonyms
- 2-Phenylpiperizine;2-PHENYLPIPERAZINE;m-phenylpiperazine;Piperazine, 2-phenyl-;2-Phenylpiperazine 97%;2-Phenylpiperazine ISO 9001：2015 REACH
- CBNumber
- CB6734451
- Molecular Formula
- C10H14N2
- Formula Weight
- 162.23
- MOL File
- 5271-26-1.mol
2-Phenylpiperazine Property
- Melting point:
- 83-87 °C (lit.)
- Boiling point:
- 138 °C
- Density
- 0.997±0.06 g/cm3(Predicted)
- storage temp.
- Storage temp. 2-8°C
- form
- solid
- pka
- 8.80±0.40(Predicted)
- color
- Yellow
- CAS DataBase Reference
- 5271-26-1(CAS DataBase Reference)
Safety
- Hazard Codes
- Xn,Xi
- Risk Statements
- 22-36/37/38
- Safety Statements
- 26-36/37
- RIDADR
- UN3259
- WGK Germany
- 2
- Hazard Note
- Irritant
- HazardClass
- 8
- HS Code
- 29335990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 638641
- Product name
- 2-Phenylpiperazine
- Purity
- 96%
- Packaging
- 5g
- Price
- $64
- Updated
- 2025/07/31
- Product number
- 638641
- Product name
- 2-Phenylpiperazine
- Purity
- 96%
- Packaging
- 25g
- Price
- $650
- Updated
- 2023/01/07
- Product number
- 287568
- Product name
- 2-PhenyLpiperazine
- Packaging
- 5g
- Price
- $475
- Updated
- 2021/12/16
- Product number
- J50071
- Product name
- 2-Phenylpiperazine
- Packaging
- 25g
- Price
- $640
- Updated
- 2021/12/16
- Product number
- CHM1053720
- Product name
- 2-PHENYLPIPERAZINE
- Purity
- 95.00%
- Packaging
- 5G
- Price
- $848.25
- Updated
- 2021/12/16
2-Phenylpiperazine Chemical Properties,Usage,Production
Uses
2-Phenylpiperazine is the starting material for the synthesis of 2-phenylpiperazine compounds. It has been synthesized 1,4-dimethyl-2-phenylpiperazine, 1,4-diethyl-2-phenyl Piperazine etc.
Synthesis
5368-28-5
5271-26-1
General procedure for the synthesis of 2-phenylpiperazine from 3-oxo-2-phenylpiperazine: 2-oxo-3-phenylpiperazine (1.76 g, 10 mmol) was dissolved in 30 mL of anhydrous THF and added slowly and dropwise to 20 mL (20 mmol) of a THF solution of 1M LiAlH4. The reaction mixture was stirred at room temperature for 24 hours. Upon completion of the reaction, water and 20% NaOH solution were carefully added to quench the excess LiAlH4. Subsequently, the reaction mixture was filtered and the filter cake was re-extracted with ethyl acetate. The organic filtrate and extract were combined, dried with MgSO4, filtered and concentrated under reduced pressure to give a light yellow solid. The crude product was further purified by silica gel column chromatography (eluent: CHCl3:MeOH:NH4OH = 9:1:0.1) to afford 2-phenylpiperazine (960 mg, 6 mmol, 60% yield) as a colorless solid. The product was characterized by 1H NMR (CDCl3): δ 2.69 (1H, t, J = 11.3 Hz), 2.85-3.10 (7H, m), 3.76 (1H, br d, J = 8.9 Hz), 7.21-7.38 (5H, m). Melting point determination (capillary method): 79-81°C.
References
[1] Patent: WO2004/63150, 2004, A2. Location in patent: Page 28-29
[2] Patent: US2005/222166, 2005, A1. Location in patent: Page/Page column 13
[3] Patent: EP1396487, 2004, A1. Location in patent: Page 17-18
2-Phenylpiperazine Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 2-Phenylpiperazine manufacturers
- Product
- 2-Phenylpiperazine 5271-26-1
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.00%
- Supply Ability
- 100 Tons
- Release date
- 2022-02-23
- Product
- 2-Phenylpiperazine 5271-26-1
- Price
- US $0.00/KG
- Min. Order
- 1KG
- Purity
- 90%-99.9%
- Supply Ability
- 500kg
- Release date
- 2019-07-05