4-(2-BROMOETHYL)-1-PIPERAZINECARBOXYLIC ACID, 1,1-DIMETHYLETHYL ESTER

Product Name: 4-(2-BROMOETHYL)-1-PIPERAZINECARBOXYLIC ACID, 1,1-DIMETHYLETHYL ESTER
CAS No.: 655225-01-7
Chemical Name: 4-(2-BROMOETHYL)-1-PIPERAZINECARBOXYLIC ACID, 1,1-DIMETHYLETHYL ESTER
Synonyms: tert-Butyl 4-(2-bromoethyl);1-Boc-4-(2-BroMoethyl)piperazine;1-(2-Bromoethyl)-4-Boc-piperazine;tert-butyl 4-(2-bromoethyl)piperazine-1-carboxylate;4-(2-BROMOETHYL)-1-PIPERAZINECARBOXYLIC ACID, 1,1-DIMETHYLETHYL ESTER;1-Piperazinecarboxylic acid, 4-(2-bromoethyl)-, 1,1-dimethylethyl ester
CBNumber: CB6743967
Molecular Formula: C11H21BrN2O2
Formula Weight: 293.2
MOL File: 655225-01-7.mol

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4-(2-BROMOETHYL)-1-PIPERAZINECARBOXYLIC ACID, 1,1-DIMETHYLETHYL ESTER Property

Boiling point:: 331.5±37.0 °C(Predicted)
Density: 1.294±0.06 g/cm3(Predicted)
storage temp.: Sealed in dry,Store in freezer, under -20°C
pka: 6.01±0.10(Predicted)
Appearance: White to off-white Solid
InChI: InChI=1S/C11H21BrN2O2/c1-11(2,3)16-10(15)14-8-6-13(5-4-12)7-9-14/h4-9H2,1-3H3
InChIKey: IWSFZKCIZFXAFT-UHFFFAOYSA-N
SMILES: N1(C(OC(C)(C)C)=O)CCN(CCBr)CC1

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

AK Scientific

Product number: 6548BB
Product name: Tert-butyl4-(2-bromoethyl)piperazine-1-carboxylate
Packaging: 250mg
Price: $253
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: HCH0012645
Product name: 4-(2-BROMOETHYL)-1-PIPERAZINECARBOXYLIC ACID, 1,1-DIMETHYLETHYL ESTER
Purity: 95.00%
Packaging: 250MG
Price: $278.25
Updated: 2021/12/16

Matrix Scientific

Product number: 121498
Product name: tert-Butyl4-(2-bromoethyl)-piperazine-1-carboxylate
Packaging: 5g
Price: $1085
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: HCH0012645
Product name: 4-(2-BROMOETHYL)-1-PIPERAZINECARBOXYLIC ACID, 1,1-DIMETHYLETHYL ESTER
Purity: 95.00%
Packaging: 1G
Price: $1188.5
Updated: 2021/12/16

Ambeed

Product number: A116534
Product name: tert-Butyl4-(2-bromoethyl)piperazine-1-carboxylate
Purity: 97%
Packaging: 100mg
Price: $26
Updated: 2021/12/16

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4-(2-BROMOETHYL)-1-PIPERAZINECARBOXYLIC ACID, 1,1-DIMETHYLETHYL ESTER Chemical Properties,Usage,Production

Synthesis

77279-24-4

655225-01-7

General procedure for the synthesis of N-BOC-4-bromoethylpiperazine from tert-butyl 4-(2-hydroxyethyl)piperazine-1-carboxylate: carbon tetrabromide (1.681 g, 5.07 mmol) was dissolved in dichloromethane (17 ml) and cooled in an ice bath. Subsequently, tert-butyl 4-(2-hydroxyethyl)piperazine-1-carboxylate (1.062 g, 4.61 mmol) and triphenylphosphine (1.329 g, 5.07 mmol) were added to this solution. The reaction mixture was stirred overnight at room temperature and additional dichloromethane (11 ml) was added. After completion of the reaction, the solvent was removed by evaporation. The residue was purified by silica gel column chromatography (using a SNAP ULTRA 25g column with hexane/ethyl acetate solvent mixture as eluent) to afford N-BOC-4-bromoethylpiperazine (1.131 g, 83.7% yield) as a yellow solid.

References

[1] Patent: JP2016/124812, 2016, A. Location in patent: Paragraph 0367
[2] Patent: WO2013/64919, 2013, A1. Location in patent: Page/Page column 37; 38
[3] Journal of Medicinal Chemistry, 2004, vol. 47, # 3, p. 711 - 719
[4] Patent: WO2010/39947, 2010, A1. Location in patent: Page/Page column 98

4-(2-BROMOETHYL)-1-PIPERAZINECARBOXYLIC ACID, 1,1-DIMETHYLETHYL ESTER Preparation Products And Raw materials

Raw materials

Preparation Products

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4-(2-BROMOETHYL)-1-PIPERAZINECARBOXYLIC ACID, 1,1-DIMETHYLETHYL ESTER Suppliers

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655225-01-7, 4-(2-BROMOETHYL)-1-PIPERAZINECARBOXYLIC ACID, 1,1-DIMETHYLETHYL ESTERRelated Search:

4-(2-BROMOPROPYL)-1-PIPERAZINECARBOXYLIC ACID, 1,1-DIMETHYLETHYL ESTER 4-(2-BROMOETHYL)-1-PIPERAZINECARBOXYLIC ACID, 1,1-DIMETHYLETHYL ESTER

4-(2-BROMOETHYL)-1-PIPERAZINECARBOXYLIC ACID, 1,1-DIMETHYLETHYL ESTER

tert-butyl 4-(2-bromoethyl)piperazine-1-carboxylate

1-Boc-4-(2-BroMoethyl)piperazine

tert-Butyl 4-(2-bromoethyl)

1-(2-Bromoethyl)-4-Boc-piperazine

1-Piperazinecarboxylic acid, 4-(2-bromoethyl)-, 1,1-dimethylethyl ester

655225-01-7

C11H21BrN2O2