CHLORCYCLIZINE HYDROCHLORIDE

Product Name: CHLORCYCLIZINE HYDROCHLORIDE
CAS No.: 1620-21-9
Chemical Name: CHLORCYCLIZINE HYDROCHLORIDE
Synonyms: CHLORCYCLIZINE HCL;Chlorcyclizine hydrochloride (1:x);MPB Chlorcyclizine Hydrochloride;1-[(4-CHLOROPHENYL)PHENYL-METHYL]-4-METHYLPIPERAZINE HYDROCHLORIDE;Piperazine, 1-(4-chlorophenyl)phenylmethyl-4-methyl-, hydrochloride;Piperazine,1-(p-chloro-a-phenylbenzyl)-4-methyl-,hydrochloride (6CI,8CI)
CBNumber: CB6747268
Molecular Formula: C18H22Cl2N2
Formula Weight: 337.29
MOL File: 1620-21-9.mol

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CHLORCYCLIZINE HYDROCHLORIDE Property

Melting point:: 226-227°
EPA Substance Registry System: Chlorcyclizine hydrochloride (1620-21-9)

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H351Suspected of causing cancer

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Chemenu

Product number: CM169997
Product name: 1-((4-chlorophenyl)(phenyl)methyl)-4-methylpiperazinehydrochloride
Purity: 95%
Packaging: 1g
Price: $529
Updated: 2021/12/16

Crysdot

Product number: CD11243614
Product name: 1-((4-Chlorophenyl)(phenyl)methyl)-4-methylpiperazinehydrochloride
Purity: 95+%
Packaging: 1g
Price: $559
Updated: 2021/12/16

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CHLORCYCLIZINE HYDROCHLORIDE Chemical Properties,Usage,Production

Originator

Perazil,Burroughs-Wellcome,US,1949

Uses

H1-antihistamine

Manufacturing Process

0.08 mol (19 9) of 4-chlorobenzhydryl chloride and 0.16 mol (16 g) of methylpiperazine were mixed in about 20 cc of dry benzene. The flask containing the reaction mixture was covered by a watch glass and set in a steam bath, and heating was continued for 6 hours. The contents of the flask were partitioned between ether and water and the ethereal layer was washed with water until the washings were neutral. The ethereal layer was extracted successively with 30 and 10 cc portions of 3 N hydrochloric acid. On evaporation of the ether layer there remained a residue of 2.5 9. The aqueous extracts were united and basified with concentrated alkali. The oily base was taken into ether and dried over potassium carbonate. On evaporation of the ether, N-methyl-N'-(4-chlorobenzhydryl) piperazine was recovered in the form of a viscous oil in 75% yield. The N-methyl-N'-(4-chlorobenzhydryl) piperazine was dissolved in absolute alcohol and ethanolic hydrogen chloride added in excess. The dihydrochloride crystallized on addition of absolute ether and was recrystallized from the same solvent mixture in the form of longish prisms melting at about 216°C.

Therapeutic Function

Antihistaminic

General Description

Chlorcyclizinehydrochloride, 1-(p-chloro-α-phenylbenzyl)-4-methylpiperazinemonohydrochioride, is a light-sensitive, white crystallinepowder that is soluble in water (1:2), in alcohol(1:11), and in chloroform (1:4). A 1% solution has a pH between4.8 and 5.5. Disubstitution or substitution of halogenin the 2- or 3-position of the benzhydryl rings results in amuch less potent compound. Chlorcydizine is indicated forthe symptomatic relief of urticaria, hay fever, and certainother conditions.

CHLORCYCLIZINE HYDROCHLORIDE Preparation Products And Raw materials

Raw materials

Preparation Products

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CHLORCYCLIZINE HYDROCHLORIDE Suppliers

China 43 Europe 2 France 1 Germany 1 India 2 Slovakia 1 United States 6 Global 56

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1620-21-9, CHLORCYCLIZINE HYDROCHLORIDERelated Search:

Fluvoxamine CHLORCYCLIZINE FLUVOXAMINE MALEATE IMPURITY STANDARD Oxiranemethanol acetate CHLORCYCLIZINE HCL,CHLORCYCLIZINE HYDROCHLORIDE

Chlorcyclizine hydrochloride (1:x)

CHLORCYCLIZINE HCL

1-[(4-CHLOROPHENYL)PHENYL-METHYL]-4-METHYLPIPERAZINE HYDROCHLORIDE

Piperazine, 1-(4-chlorophenyl)phenylmethyl-4-methyl-, hydrochloride

MPB Chlorcyclizine Hydrochloride

Piperazine,1-(p-chloro-a-phenylbenzyl)-4-methyl-,hydrochloride (6CI,8CI)

1620-21-9

C18H22Cl2N2

C18H21ClN2xClH

DI-PARALENE