Tetrahydrouridine

ChemicalBook > CAS DataBase List > Tetrahydrouridine

Description Laboratory Procedures

Product Name: Tetrahydrouridine
CAS No.: 18771-50-1
Chemical Name: Tetrahydrouridine
Synonyms: nsc-112907;nsc-112907-d;DFMA | RMI 71897;TETRAHYDROURIDINE;3,4,5,6-tetrahydrouridine;Tetrahydrouridine dihydrate;Uridine, 3,4,5,6-tetrahydro-;3,4,5,6-Tetrahydrouridine (>3,4,5,6-Tetrahydrouridine (>80%);Tetrahydrouridine (aqueous solution)
CBNumber: CB6748654
Molecular Formula: C9H16N2O6
Formula Weight: 248.23
MOL File: 18771-50-1.mol

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Tetrahydrouridine Property

Melting point:: >195°C (dec.)
Boiling point:: 668.6±55.0 °C(Predicted)
Density: 1.622±0.06 g/cm3(Predicted)
storage temp.: Keep in dark place,Sealed in dry,2-8°C
solubility: Methanol (Slightly), Water (Slightly)
form: Solid
pka: 12.50±0.40(Predicted)
color: White to Off-White
Stability:: Light Sensitive

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 584223
Product name: InSolution Tetrahydrouridine - CAS 18771-50-1 - Calbiochem
Purity: Tetrahydrouridine is a potent competitive inhibitor of cytidine deaminase.
Packaging: 25mg
Price: $318
Updated: 2024/03/01

Sigma-Aldrich

Product number: 584222
Product name: Tetrahydrouridine - CAS 18771-50-1 - Calbiochem
Packaging: 10mg
Price: $226
Updated: 2024/03/01

Cayman Chemical

Product number: 16402
Product name: Tetrahydrouridine
Purity: ≥80%
Packaging: 10mg
Price: $163
Updated: 2024/03/01

Cayman Chemical

Product number: 16402
Product name: Tetrahydrouridine
Packaging: 25mg
Price: $345
Updated: 2024/03/01

Cayman Chemical

Product number: 16402
Product name: Tetrahydrouridine
Packaging: 50mg
Price: $649
Updated: 2024/03/01

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Tetrahydrouridine Chemical Properties,Usage,Production

Description

Tetrahydrouridine is a competitive, reversible inhibitor of cytidine deaminase (Ki values = 54 and 240 nM for human and E. coli enzymes, respectively).Its use, alone or in combination with the DNA methyltransferase inhibitor 5-fluoro-2'-deoxycytidine, is being evaluated in animal models and clinical trials for diseases, including cancer and mitochondrial DNA depletion syndrome.

Laboratory Procedures

Tetrahydrouridine is supplied as a crystalline solid. A stock solution may be made by dissolving the tetrahydrouridine in the solvent of choice. Tetrahydrouridine is soluble in organic solvents such as DMSO and dimethyl formamide, which should be purged with an inert gas. The solubility of tetrahydrouridine in these solvents is approximately 10 and 16 mg/ml, respectively.
Further dilutions of the stock solution into aqueous buffers or isotonic saline should be made prior to performing biological experiments. Ensure that the residual amount of organic solvent is insignificant, since organic solvents may have physiological effects at low concentrations. Organic solvent-free aqueous solutions of tetrahydrouridine can be prepared by directly dissolving the crystalline solid in aqueous buffers. The solubility of tetrahydrouridine in PBS, pH 7.2, is approximately 5 mg/ml. We do not recommend storing the aqueous solution for more than one day.

Description

Tetrahydrouridine is a competitive, reversible inhibitor of cytidine deaminase (K_i values = 54 and 240 nM for human and E. coli enzymes, respectively). Its use, alone or in combination with the DNA methyltransferase inhibitor 5-fluoro-2’-deoxycytidine, is being evaluated in animal models and clinical trials for diseases, including cancer and mitochondrial DNA depletion syndrome.

Uses

3,4,5,6-Tetrahydrouridine, is a derivative of Uridine (U829910). Tetrahydrouridine (THU), is a potent inhibitor of cytidine. It inhibits cell proliferation through cell cycle regulation regardless of cytidine deaminase expression levels deaminase (CDA), and thus can be used as a potential and promising treatment for tumors with highly expressed CDA.

Tetrahydrouridine Preparation Products And Raw materials

Raw materials

Preparation Products

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18771-50-1, TetrahydrouridineRelated Search:

Gemcitabine Cytarabine Adenine Uridine Diphosphate Choline UDP-ALPHA-D-N-ACETYLGLUCOSAMINE, DISODIUM SALT [[(2S,3R,4R,5S,6R)-3-acetamido-4,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy 2',2'-DIFLUORO-2'-DEOXYURIDINE 1-((2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)-3-methylene-tetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione 1-(-D-Xylofuranosyl)uracil URIDINE 5'-DIPHOSPHOGLUCOSE DISODIUM SALT Uridine Diphosphate Choline (UDPC) Sodium Salt [5-(2,4-dioxo-1H-pyrimidin-5-yl)-3,4-dihydroxy-oxolan-2-yl]methoxyphosphonic acid 2,4(1H,3H)-Pyrimidinedione, 5-[5-O-[(1,1-dimethylethyl)diphenylsilyl]-β-D-ribofuranosyl]- 2,4(1H,3H)-Pyrimidinedione, 5-[5-O-[hydroxy(phosphonooxy)phosphinyl]-β-D-ribofuranosyl]- alpha-D-ribofuranose 5-(dihydrogen phosphate) 1-(trihydrogen diphosphate) Propyleneurea Tetrahydrouridine 5,6-Dihydrouridine

3,4,5,6-tetrahydrouridine

nsc-112907

nsc-112907-d

tetrahydro-4-hydroxy-1-beta-d-ribofuranosyl-2(1h)-pyrimidinon

TETRAHYDROURIDINE

3,4,5,6-Tetrahydrouridine (>80% by HPLC)

Uridine, 3,4,5,6-tetrahydro-

(4S)-3,4,5,6-Tetrahydro-4β-hydroxy-1-(β-D-ribofuranosyl)pyrimidin-2(1H)-one

3,4,5,6-Tetrahydrouridine (&gt

Tetrahydrouridine dihydrate

Uridine Impurity 27（Tetrahydrouridine）

3,4,5,6-Tetrahydrouridine (>80%)

1-((2R,3R,4S,5R)-3,4-Dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-4-hydroxytetrahydropyrimidin-2(1H)-one

DFMA | RMI 71897

Tetrahydro uridineQ: What is Tetrahydro uridine Q: What is the CAS Number of Tetrahydro uridine Q: What is the storage condition of Tetrahydro uridine Q: What are the applications of Tetrahydro uridine

Tetrahydrouridine (aqueous solution)

18771-50-1