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Ethynodiol diacetate

Product Name
Ethynodiol diacetate
CAS No.
297-76-7
Chemical Name
Ethynodiol diacetate
Synonyms
Femulen;CB-8080;ovulen50;SC 11800;8080c.b.;Etynodiol;Luteonorm;Metrodiol;Ovulen 50;Continuin
CBNumber
CB6749404
Molecular Formula
C24H32O4
Formula Weight
384.51
MOL File
297-76-7.mol
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Ethynodiol diacetate Property

Melting point:
~126-127°
alpha 
D -72.5° (chloroform)
Boiling point:
431.17°C (rough estimate)
Density 
1.0474 (rough estimate)
refractive index 
1.4860 (estimate)
storage temp. 
2-8°C
solubility 
Chloroform (Slightly), DMSO (Slightly)
form 
Solid
color 
White
Water Solubility 
1.4mg/L(25 ºC)
CAS DataBase Reference
297-76-7(CAS DataBase Reference)
NIST Chemistry Reference
Ethynodiol diacetate(297-76-7)
EPA Substance Registry System
Ethynodiol diacetate (297-76-7)
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Safety

Hazard Codes 
Xn
Risk Statements 
20/21/22-40
Safety Statements 
22-36
WGK Germany 
3
RTECS 
RC8963000
HS Code 
2937230000
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H351Suspected of causing cancer

Precautionary statements

P201Obtain special instructions before use.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P308+P313IF exposed or concerned: Get medical advice/attention.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
E7263
Product name
Ethynodiol diacetate
Packaging
500mg
Price
$100
Updated
2024/03/01
Sigma-Aldrich
Product number
1268003
Product name
Ethynodiol diacetate
Purity
United States Pharmacopeia (USP) Reference Standard
Packaging
200mg
Price
$393
Updated
2024/03/01
TCI Chemical
Product number
E1315
Product name
Ethynodiol Diacetate
Packaging
1G
Price
$120
Updated
2024/03/01
TCI Chemical
Product number
E1315
Product name
Ethynodiol Diacetate
Packaging
5G
Price
$413
Updated
2024/03/01
Cayman Chemical
Product number
29854
Product name
Ethynodiol Diacetate
Packaging
500mg
Price
$81
Updated
2024/03/01
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Ethynodiol diacetate Chemical Properties,Usage,Production

Description

Ethynodiol diacetate is a synthetic progestogen. It prevents the development of osteoporosis in ovariectomized rats when administered at a dose of 9 μg/animal per day. Ethynodiol diacetate inhibits copulatory ovulation in rabbits. Formulations containing ethynodiol diacetate have been used as oral contraceptives.

Originator

Lutometrodiol,Searle,France,1965

Uses

anticonvulsant

Uses

Ethynodiol Diacetate is used as a hormonal contraceptive, birth control.

Definition

ChEBI: Ethynodiol diacetate is a steroid ester and a terminal acetylenic compound. It has a role as an estrogen receptor modulator, a contraceptive drug and a synthetic oral contraceptive. It is functionally related to an ethynodiol.

Manufacturing Process

A mixture of 30 parts of 17α-ethynyl-19-norandrost-4-ene-3β,17β-diol, 360 parts of dry pyridine, and 111 parts of acetic anhydride, under nitrogen, is stirred and heated at the reflux temperature for about 5 hours. This reaction mixture is cooled, then poured into approximately 3,500 parts of cold water and the resulting aqueous mixture is stirred at room temperature for about 0.5 hour. The precipitate which forms is collected by filtration, then is washed on the filter with water and dried in air. This solid material is extracted into ether, and the ether solution is washed successively with 10% aqueous

Therapeutic Function

Progestin; Oral contraceptive ingredient

General Description

Ethynodiol diacetate, 19-norpregn-4-en-20-yne-3β,17α-diol diacetate, is a prodrug ofnorethindrone. A combination of hydrolysis of both estersand oxidation of the C3 alcohol to the ketone is necessary toprovide the fully active progestin.

Safety Profile

Suspected carcinogen. Human reproductive effects by ingestion: menstrual cycle changes. Experimental reproductive effects. Mutation data reported. A steroid. When heated to decomposition it emits acrid smoke and irritating fumes.

Ethynodiol diacetate Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Ethynodiol diacetate manufacturers

Wuhan Haorong Biotechnology Co.,Ltd
Product
Ethynodiol diacetate 297-76-7
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
5000
Release date
2023-07-27
WUHAN CIRCLE POWDER TECHNOLOGY CO.,LTD
Product
Ethynodiol diacetate 297-76-7
Price
US $0.00/KG
Min. Order
100g
Purity
98%+
Supply Ability
100kg
Release date
2020-10-12
Nantong Guangyuan Chemicl Co,Ltd
Product
Ethynodiol diacetate 297-76-7
Price
US $10.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
1000kg
Release date
2023-11-03

297-76-7, Ethynodiol diacetateRelated Search:

Levonorgestrel Pancuronium bromide Norethindrone Lynestrenol (S)-1-OCTYN-3-OL 4-METHYL-1-PENTYN-3-OL PROPARGYL ACETATE 10-UNDECYN-1-OL 3,4-DIMETHYL-1-PENTYN-3-OL 19-Norandrostenediol 3,5-DIMETHYL-1-HEXYN-3-OL 3-CYCLOHEXYL-1-PROPYNE 3-METHYL-1-DODECYN-3-OL 1-HEXADECYNE 3-METHYL-1-NONYN-3-OL 1-PENTADECYNE NOR-1 3-METHYL-1-OCTYN-3-OL

  • (3-beta,17-alpha)-19-Norpregn-4-en-20-yne-3,17-diol diacetate
  • (3-beta,17-alpha)-19-norpregn-4-en-20-yne-3,17-dioldiacetate
  • 17-(Acetyloxy)-17-ethynylestr-4-en-3-yl acetate
  • 17-alpha-Ethynyl-19-norandrost-4-ene-3-beta,17-beta-diol diacetate
  • 17-alpha-ethynyl-19-norandrost-4-ene-3-beta,17-beta-dioldiacetate
  • 17-alpha-Ethynyl-3,17-dihydroxy-4-estrene diacetate
  • 17-alpha-ethynyl-3,17-dihydroxy-4-estrenediacetate
  • 17-alpha-Ethynyl-4-estrene-3-beta,17-beta-diol diacetate
  • 17-alpha-ethynyl-4-estrene-3-beta,17-beta-dioldiacetate
  • 17-alpha-Ethynyl-4-estrene-3-beta,17-diol diacetate
  • 17-alpha-ethynyl-4-estrene-3-beta,17-dioldiacetate
  • 17-alpha-Ethynylestr-4-ene-3-beta,17-beta-diol acetate
  • acetic acid [(3S,8R,9S,10R,13S,14S,17R)-17-acetyloxy-17-ethynyl-13-methyl-2,3,6,7,8,9,10,11,12,14,15,16-dodecahydro-1H-cyclopenta[a]phenanthren-3-yl] ester
  • component of Demulen
  • component of Demulon
  • component of Luteolas
  • component of Metrulen
  • component of Miniluteolas
  • component of Ovaras
  • Ethinodiol diacetate
  • ethinodioldiacetate
  • Ethynodiol
  • ethynodiolacetate
  • Etynodiol
  • Femulen
  • Luteonorm
  • Luto-metrodiol
  • Metrodiol
  • Metrodiol diacetate
  • metrodioldiacetate
  • Ovulen 50
  • ovulen50
  • SC 11800
  • 3BETA,17BETA-DIACETOXY-17ALPHA-ETHYNYL-4-ESTRENE
  • ETHYNODIOL DIACETATE
  • 19-nor-17a-pregn-4-en-20-yne-3b,17-diol diacetate
  • 17alpha-ethynyl-4-estrene-3b,17b-diol-3,17-diacetate
  • 8080c.b.
  • beta-Ethynodiol diacetate
  • beta-ethynodioldiacetate
  • Cervicundin
  • component of Conova
  • 4-ESTREN-17-ALPHA-ETHYNYL-3-BETA, 17-BETA-DIOL DIACETATE
  • 17-alpha-ethynylestr-4-ene-3-beta,17-beta-diolacetate
  • 19-Nor-17alpha-pregn-4-en-20-yn-3beta,17-diol diacetate
  • 19-Nor-17-alpha-pregn-4-en-20-yne-3-beta,17-diol diacetate
  • 19-nor-17-alpha-pregn-4-en-20-yne-3-beta,17-diol,diacetate
  • 19-Norpregn-4-en-20-yne-3,17-diol, diacetate, (3beta,17alpha)-
  • 3-beta, 17-beta-Diacetoxy-17-alpha-ethynyl-4-oestrene
  • 3-beta,17-beta-diacetoxy-17-alpha-ethynyl-4-oestrene
  • 3-beta,17-beta-Diacetoxy-19-nor-17-alpha-pregn-4-en-20-yne
  • 8080 C. B.
  • 17a-Ethynyl-4-estren-3b,17-diol diacetate
  • 19-Norpregn-4-en-20-yne-3,17-diol, 3,17-diacetate, (3β,17α)-
  • (3β, 17α)-19-Norpregn-4-en-20-yne-3,17-diol diacetate
  • Etynodiol acetate
  • Double vinegar ethynodiol
  • etynodiol di(acetate)