3-OXO-3-(4-TRIFLUOROMETHYLPHENYL)PROPIONIC ACID ETHYL ESTER
- Product Name
- 3-OXO-3-(4-TRIFLUOROMETHYLPHENYL)PROPIONIC ACID ETHYL ESTER
- CAS No.
- 106263-53-0
- Chemical Name
- 3-OXO-3-(4-TRIFLUOROMETHYLPHENYL)PROPIONIC ACID ETHYL ESTER
- Synonyms
- ETHYL (4-TRIFLUOROMETHYLBENZOYL)ACETATE;Ethyl 2-[4-(TrifluoroMethyl)benzoyl]acetate;Ethyl β-oxo-4-(trifluoromethyl)benzenepropanoate;Ethyl 3-(4-trifluoromethylphenyl)-3-oxopropionate;ETHYL 3-(4-TRIFLUOROMETHYL-PHENYL)-3-OXOPROPANOATE;Ethyl 3-oxo-3-(4-(trifluoromethyl)phenyl)propanoat;ETHYL Β-OXO-4-(TRIFLUOROMETHYL)-BENZENEPROPANOIC ACID;ethyl β-oxo-4-(trifluoromethyl)-benzenepropanoic acid;3-OXO-3-(4-TRIFLUOROMETHYLPHENYL)PROPIONIC ACID ETHYL ESTER;3-Oxo-3-(4-trifluoromethylphenyl)propanoic acid ethyl ester
- CBNumber
- CB6763392
- Molecular Formula
- C12H11F3O3
- Formula Weight
- 260.21
- MOL File
- 106263-53-0.mol
3-OXO-3-(4-TRIFLUOROMETHYLPHENYL)PROPIONIC ACID ETHYL ESTER Property
- Boiling point:
- 248-249 °C(lit.)
- Density
- 1.270 g/mL at 25 °C(lit.)
- refractive index
- n20/D 1.4880(lit.)
- Flash point:
- >230 °F
- storage temp.
- Sealed in dry,Room Temperature
- pka
- 9.09±0.25(Predicted)
- form
- liquid
- color
- Light yellow
- CAS DataBase Reference
- 106263-53-0(CAS DataBase Reference)
Safety
- Hazard Codes
- F
- WGK Germany
- 3
- HS Code
- 2918300090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H312Harmful in contact with skin
H315Causes skin irritation
H319Causes serious eye irritation
H332Harmful if inhaled
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P330Rinse mouth.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
P403+P233Store in a well-ventilated place. Keep container tightly closed.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- 559059
- Product name
- Ethyl (4-trifluoromethylbenzoyl)acetate
- Packaging
- 5g
- Price
- $149
- Updated
- 2023/06/20
- Product number
- E937265
- Product name
- Ethyl3-Oxo-3-[4-(trifluoromethyl)phenyl]propanoate
- Packaging
- 50mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- E937265
- Product name
- Ethyl3-Oxo-3-[4-(trifluoromethyl)phenyl]propanoate
- Packaging
- 500mg
- Price
- $90
- Updated
- 2021/12/16
- Product number
- 1412AA
- Product name
- Ethyl3-oxo-3-(4-(trifluoromethyl)phenyl)propanoate
- Packaging
- 250mg
- Price
- $84
- Updated
- 2021/12/16
- Product number
- PC1854
- Product name
- Ethyl 3-oxo-3-[4-(trifluoromethyl)phenyl]propanoate
- Packaging
- 1g
- Price
- $196
- Updated
- 2021/12/16
3-OXO-3-(4-TRIFLUOROMETHYLPHENYL)PROPIONIC ACID ETHYL ESTER Chemical Properties,Usage,Production
Uses
Reactant for:
- In-catalyzed cycloisomerization
- Chiral Lewis base-catalyzed stereoselective reduction with trichlorosilane and water
- Guanidine-catalyzed enantioselective Michael reactions
- Transesterification reactions
- Intermolecular coupling reactions
Synthesis
15226-74-1
402-43-7
6148-64-7
106263-53-0
To a stirred 30 mL microwave vial was added a solution of aryl or heteroaryl halides (Br, I) (0.5 mmol) and monoethyl malonate potassium salt (0.75 mmol) in THF (10 mL). Pd(OAc)2 (5 mol%), Xantphos (5 mol%), MgCl2 (0.75 mmol), Et3N (0.75 mmol), imidazole (1 mmol), and Co2(CO)8 (0.15 mmol) were then added sequentially. The vials were immediately sealed and subjected to microwave irradiation at 90 °C for 30 min. After completion of the reaction, the mixture was concentrated and diluted with ethyl acetate and water. The organic layer (ethyl acetate layer) was separated, dried over anhydrous sodium sulfate and then concentrated. The crude product was purified by column chromatography to afford the target compound ethyl 4-trifluoromethylbenzoylacetate.
References
[1] Tetrahedron Letters, 2014, vol. 55, # 25, p. 3525 - 3528
3-OXO-3-(4-TRIFLUOROMETHYLPHENYL)PROPIONIC ACID ETHYL ESTER Preparation Products And Raw materials
Raw materials
Preparation Products
3-OXO-3-(4-TRIFLUOROMETHYLPHENYL)PROPIONIC ACID ETHYL ESTER Suppliers
- Tel
- 18210857532; 18210857532
- Fax
- 86-10-82849933
- jkinfo@jkchemical.com
- Country
- China
- ProdList
- 96815
- Advantage
- 76
- Tel
- 021-021-58432009 400-005-6266
- Fax
- 021-58436166
- sales8178@energy-chemical.com
- Country
- China
- ProdList
- 44801
- Advantage
- 61
- Tel
- 021-54306202 13764082696
- info@hanhongsci.com
- Country
- China
- ProdList
- 42934
- Advantage
- 64
- Tel
- 021-58388037;21-58388037 13472507714
- 35177634@qq.com;1589045147@qq.com
- Country
- China
- ProdList
- 803
- Advantage
- 55
- Tel
- 027-88041443 13072715837
- Fax
- 027-51829379
- sales@hetero-chem.com
- Country
- China
- ProdList
- 696
- Advantage
- 58
- Tel
- 22-58627059 13920586291
- Fax
- 022-58620305
- zdcomcon@126.com
- Country
- China
- ProdList
- 3829
- Advantage
- 50
- Tel
- 15921303235
- Fax
- QQ489466966
- sales@synthfine.com
- Country
- China
- ProdList
- 1043
- Advantage
- 58
- Tel
- 86-21-34053660
- Fax
- 86-21-34053661
- sale@labgogo.com
- Country
- China
- ProdList
- 9865
- Advantage
- 52
- Tel
- 021-58170097
- info@topbiochem.com
- Country
- China
- ProdList
- 9510
- Advantage
- 58
- Tel
- 400-6206333 13167063860
- Fax
- 021-50323701
- anhua.mao@aladdin-e.com
- Country
- China
- ProdList
- 25003
- Advantage
- 65
View Lastest Price from 3-OXO-3-(4-TRIFLUOROMETHYLPHENYL)PROPIONIC ACID ETHYL ESTER manufacturers
- Product
- 3-OXO-3-(4-TRIFLUOROMETHYLPHENYL)PROPIONIC ACID ETHYL ESTER 106263-53-0
- Price
- US $3.00/KG
- Min. Order
- 200KG
- Purity
- 98%
- Supply Ability
- 20000KG
- Release date
- 2020-01-07