2-(2-Methylphenoxy)-4H-1,3,2-benzodioxaphosphorin 2-oxide
- Product Name
- 2-(2-Methylphenoxy)-4H-1,3,2-benzodioxaphosphorin 2-oxide
- CAS No.
- 1222-87-3
- Chemical Name
- 2-(2-Methylphenoxy)-4H-1,3,2-benzodioxaphosphorin 2-oxide
- Synonyms
- cbdp;o-Tolyl saligenin phosphate;2-(o-cresyl)-4h-1,3,2-benzodioxaphoran-2-one;2-(2-cresyl)-4h-1-3-2-benzodioxaphosphorin-2-oxide;3,2-benzodioxaphosphorin,2-(o-tolyloxy)-4h-2-oxide;phosphoricacid,cyclicmethylene-o-phenyleneo-tolylester;3,2-benzodioxaphosphorin,2-(2-methylphenoxy)-4h-2-oxide;2-(2-METHYLPHENOXY)-4H-1,3,2-BENZODIOXAPHOSPHORIN 2-OXIDE;2-(o-Tolyloxy)-4H-benzo[d][1,3,2]dioxaphosphinine 2-Oxide;4H-1,3,2-Benzodioxaphosphorin, 2-(2-methylphenoxy)-, 2-oxide
- CBNumber
- CB6765725
- Molecular Formula
- C14H13O4P
- Formula Weight
- 276.22
- MOL File
- 1222-87-3.mol
2-(2-Methylphenoxy)-4H-1,3,2-benzodioxaphosphorin 2-oxide Property
- Boiling point:
- 362.4±42.0 °C(Predicted)
- Density
- 1.32±0.1 g/cm3(Predicted)
N-Bromosuccinimide Price
- Product number
- 30169
- Product name
- CBDP
- Packaging
- 1mg
- Price
- $95
- Updated
- 2021/12/16
- Product number
- 30169
- Product name
- CBDP
- Packaging
- 5mg
- Price
- $380
- Updated
- 2021/12/16
2-(2-Methylphenoxy)-4H-1,3,2-benzodioxaphosphorin 2-oxide Chemical Properties,Usage,Production
Uses
Plasma carboxylic-ester hydrolase (EC3.1.1.1) is a very important detoxification route for the toxic stereoisomers of soman. Detoxification is meant in the sense that if soman was bound to carbox-ylic-ester hydrolase, it was not free to inhibit acetylcholinesterase. CBDP (2-(2-Methylphenoxy)-4H-1,3,2-benzodioxaphosphorin 2-oxide) pretreatment, which inhibited irreversibly carboxylic-ester hydrolase activity without inhibiting phosphoryl phosphatase activity, potentiated the toxicity of soman in mice. In toxicity experiments, CBDP (0.5 mg/kg; iv 1 hr prior to soman) pretreatment potentiated the toxicity of C(±)P(±)-, C(+)P(?)-, and C(?)P(?)-soman to a similar degree[1].
References
[1] John G. Clement. “Stereoisomers of soman (pinacolyl methylphosphonofluoridate): Inhibition of serum carboxylic ester hydrolase and potentiation of their toxicity by CBDP (2-(2-methylphenoxy)-4H-1,3,2-benzodioxaphosphorin-2-oxide) in mice.” Toxicology and applied pharmacology 89 1 (1987): Pages 141-143.
2-(2-Methylphenoxy)-4H-1,3,2-benzodioxaphosphorin 2-oxide Preparation Products And Raw materials
Raw materials
Preparation Products
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