2-HEXADECANOYLTHIO-1-ETHYLPHOSPHORYLCHOLINE Property

storage temp. 

Store at -20°C

solubility 

Ethanol: 30 mg/ml; PBS (pH 7.2): 5 mg/ml

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H225Highly Flammable liquid and vapour

H319Causes serious eye irritation

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P233Keep container tightly closed.

P240Ground/bond container and receiving equipment.

P241Use explosion-proof electrical/ventilating/lighting/…/equipment.

P242Use only non-sparking tools.

P243Take precautionary measures against static discharge.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P337+P313IF eye irritation persists: Get medical advice/attention.

P370+P378In case of fire: Use … for extinction.

P403+P235Store in a well-ventilated place. Keep cool.

P501Dispose of contents/container to..…

2-HEXADECANOYLTHIO-1-ETHYLPHOSPHORYLCHOLINE Chemical Properties,Usage,Production

Description

Thioester analogs of glycerophospholipids, in combination with Ellman’s reagent, are convenient colorimetric substrates for the measurement of phospholipase activity. HEPC is a truncated analog of phosphatidylcholine with the entire sn-1 substituent deleted, and with a hexadecylthioester in the sn-2 position.¹ HEPC is a substrate for Type II phospholipase A₂ (PLA₂) enzymes, such as porcine pancreatic, bee venom, and snake venom PLA₂. The intrinsic biological activity of HEPC has not been actively investigated.

Definition

ChEBI: 2-hexadecanoylthio-1-ethylphosphorylcholine is a member of phosphocholines.

References

1. Bhat, M.K., Mueller-Harvey, I., Sumner, I.G., et al. Simplified methods for the synthesis of 2-hexadecanoylthio-1-ethylphosphorylcholine and for the determination of phospholipase A₂ activity Biochim. Biophys. Acta 1166,244-250(1993).