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DIHYDREXIDINE HYDROCHLORIDE

Product Name
DIHYDREXIDINE HYDROCHLORIDE
CAS No.
123039-93-0
Chemical Name
DIHYDREXIDINE HYDROCHLORIDE
Synonyms
DAR-0100;DihydrexidineHCl;Dihydrexidine hydroc;DIHYDROXIDINE HYDROCHLORIDE;DIHYDREXIDINE HYDROCHLORIDE;Benzo[a]phenanthridine-10,11-diol, 5,6,6a,7,8,12b-hexahydro-, (6aR,12bS)-rel-;(+/-)-TRANS-10,11-DIHYDROXY-5,6,6A,7,8,12B-HEXAHYDROBENZO[A]PHENANTHRIDINE HYDROCHLORIDE
CBNumber
CB6777171
Molecular Formula
C17H17NO2
Formula Weight
267.32
MOL File
123039-93-0.mol
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DIHYDREXIDINE HYDROCHLORIDE Property

Boiling point:
488.270±45.00 °C(Press: 760.00 Torr)(predicted)
Density 
1.267±0.06 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted)
storage temp. 
2-8°C
solubility 
Soluble in DMSO
form 
solid
pka
10.046±0.20(predicted)
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Safety

WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Tocris
Product number
0884
Product name
Dihydrexidinehydrochloride
Purity
≥98%(HPLC)
Packaging
5
Price
$171
Updated
2021/12/16
Tocris
Product number
0884
Product name
Dihydrexidinehydrochloride
Purity
≥98%(HPLC)
Packaging
25
Price
$675
Updated
2021/12/16
TRC
Product number
D452845
Product name
Dihydrexidine
Packaging
10mg
Price
$1320
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
API0009837
Product name
DIHYDREXIDINE HYDROCHLORIDE
Purity
95.00%
Packaging
5MG
Price
$496.02
Updated
2021/12/16
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DIHYDREXIDINE HYDROCHLORIDE Chemical Properties,Usage,Production

Uses

Dihydrexidine is a moderately selective full agonist at the dopamine D1 and D5 receptors (1,2). It has been shown to have antiparkinson effects. It also has the ability to improving the cognitive and working memory deficits in schizophrenia and schizotypal disorder.

Biological Activity

A potent, full efficacy dopamine D 1 agonist which shows no agonist activity at peripheral D 2 receptors or adrenoceptors at doses which cause maximal stimulation of D 1 sites. The compound appears to be fully bioavailable in brain and exhibits profound antiparkinsonism effects in vivo .

in vivo

Dihydrexidine has poor oral bioavailability and a relatively short half-life of 1 to 2 h[3].
Dihydrexidine (3 mg/kg; i.p.) produces prominent dopamine D1 receptor agonist effects in vivo[4].

Animal Model:Adult male Sprague–Dawley rats (275-300 g)[4]
Dosage:Adult male Sprague–Dawley rats (275-300 g)[4]
Administration:Intraperitoneal injection
Result:Produces prominent dopamine D1 receptor agonist effects in vivo

IC 50

D1 Receptor: 10 nM (IC50)

DIHYDREXIDINE HYDROCHLORIDE Preparation Products And Raw materials

Raw materials

Preparation Products

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DIHYDREXIDINE HYDROCHLORIDE Suppliers

China 17 Germany 3 India 1 Japan 1 Switzerland 1 United Kingdom 2 United States 6 Global 31
J & K SCIENTIFIC LTD.
Tel
18210857532; 18210857532
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
96815
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76
3B Pharmachem (Wuhan) International Co.,Ltd.
Tel
821-50328103-801 18930552037
Fax
86-21-50328109
Email
3bsc@sina.com
Country
China
ProdList
15838
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69
EMMX Biotechnology LLC
Tel
888-539-0666
Fax
888-539-0666
Email
info@emmx.com
Country
United States
ProdList
8447
Advantage
60
Shenzhen Polymeri Biochemical Technology Co., Ltd.
Tel
+86-400-002-6226 +86-13028896684;
Email
sales@rrkchem.com
Country
China
ProdList
57422
Advantage
58
TargetMol Chemicals Inc.
Tel
+1-781-999-5354; +17819995354
Email
marketing@targetmol.com
Country
United States
ProdList
32435
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58
Jinan ponder chemical co. LTD
Tel
0531-0000
Email
thinklifescience@163.com
Country
China
ProdList
19689
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58
Energy Chemical
Tel
021-58432009 400-005-6266
Fax
021-58436166
Email
marketing1@energy-chemical.com
Country
China
ProdList
44894
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58
cjbscvictory
Tel
13348960310
Email
3003867561@qq.com
Country
China
ProdList
10503
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58
Beijing Jin Ming Biotechnology Co., Ltd.
Tel
010-60605840 15801484223;
Email
psaitong@jm-bio.com
Country
China
ProdList
29757
Advantage
58
Shanghai Universal Biotech Co.,Ltd
Tel
15921930842 15921930842
Email
yh-wang@univ-bio.com
Country
China
ProdList
25004
Advantage
58

123039-93-0, DIHYDREXIDINE HYDROCHLORIDERelated Search:

4-phenyl-1,2,3,4-tetrahydroisoquinoline (+/-)-2-AMINO-6,7-DIHYDROXY-1,2,3,4-TETRAHYDRONAPHTHALENE HYDROBROMIDE (S)-(-)-1,1-DIPHENYL-2-AMINOPROPANE DIHYDREXIDINE HYDROCHLORIDE 4-PHENYL-1,2,3,4-TETRAHYDROISOQUINOLINE HYDROCHLORIDE

  • DIHYDREXIDINE HYDROCHLORIDE
  • (+/-)-TRANS-10,11-DIHYDROXY-5,6,6A,7,8,12B-HEXAHYDROBENZO[A]PHENANTHRIDINE HYDROCHLORIDE
  • DihydrexidineHCl
  • DIHYDROXIDINE HYDROCHLORIDE
  • DAR-0100
  • Benzo[a]phenanthridine-10,11-diol, 5,6,6a,7,8,12b-hexahydro-, (6aR,12bS)-rel-
  • Dihydrexidine hydroc
  • 123039-93-0
  • Dopamine receptor