SIAIS178

Product Name: SIAIS178
CAS No.: 2376047-73-1
Chemical Name: SIAIS178
Synonyms: SIAIS178;N-(2-chloro-6-methylphenyl)-2-({6-[4-(7-{[(2S)-1-[(2S,4R)-4-hydroxy-2-({[4-(4-methyl-1,3-thiazol-5-yl)phenyl]methyl}carbamoyl)pyrrolidin-1-yl]-3,3-dimethyl-1-oxobutan-2-yl]carbamoyl}heptanoyl)piperazin-1-yl]-2-methylpyrimidin-4-yl}amino)-1,3-thiazole-5-carboxamide
CBNumber: CB68049335
Molecular Formula: C50H62ClN11O6S2
Formula Weight: 1012.68
MOL File: 2376047-73-1.mol

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SIAIS178 Property

Density: 1.335±0.06 g/cm3(Predicted)
pka: 10.94±0.70(Predicted)
form: Solid
color: White to off-white

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

ChemScene

Product number: CS-0103903
Product name: SIAIS178
Purity: 99.48%
Packaging: 1mg
Price: $200
Updated: 2021/12/16

ChemScene

Product number: CS-0103903
Product name: SIAIS178
Purity: 99.48%
Packaging: 5mg
Price: $480
Updated: 2021/12/16

ChemScene

Product number: CS-0103903
Product name: SIAIS178
Purity: 99.48%
Packaging: 10mg
Price: $650
Updated: 2021/12/16

ChemScene

Product number: CS-0103903
Product name: SIAIS178
Purity: 99.48%
Packaging: 50mg
Price: $1950
Updated: 2021/12/16

ChemScene

Product number: CS-0103903
Product name: SIAIS178
Purity: 99.48%
Packaging: 100mg
Price: $2750
Updated: 2021/12/16

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SIAIS178 Chemical Properties,Usage,Production

Description

SIAIS178 is a potent BCR-ABL Degrader. SIAIS178 induces proper interaction between BCR-ABL and VHL ligase leading to effective degradation of BCR-ABL protein, achieves significant growth inhibition of BCR-ABL+ leukemic cells in vitro, and induces substantial tumor regression against K562 xenograft tumors in vivo. In addition, SIAIS178 also degrades several clinically relevant resistance-conferring mutations. Our data indicate that SIAIS178 as efficacious BCR-ABL degrader warrants extensive further investigation for the treatment of BCR-ABL+ leukemia.

SIAIS178 Preparation Products And Raw materials

Raw materials

Preparation Products

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SIAIS178 Suppliers

China 9 United States 1 Global 10

TargetMol Chemicals Inc.

Tel: +1-781-999-5354 +1-00000000000
Email: marketing@targetmol.com
Country: United States
ProdList: 32161
Advantage: 58

2376047-73-1, SIAIS178Related Search:

SIAIS178

N-(2-chloro-6-methylphenyl)-2-({6-[4-(7-{[(2S)-1-[(2S,4R)-4-hydroxy-2-({[4-(4-methyl-1,3-thiazol-5-yl)phenyl]methyl}carbamoyl)pyrrolidin-1-yl]-3,3-dimethyl-1-oxobutan-2-yl]carbamoyl}heptanoyl)piperazin-1-yl]-2-methylpyrimidin-4-yl}amino)-1,3-thiazole-5-carboxamide

2376047-73-1