Senaparib
Clinical research- Product Name
- Senaparib
- CAS No.
- 1401682-78-7
- Chemical Name
- Senaparib
- Synonyms
- IMP4297;IMP 4297;IMP-4297;Senaparib;Senaparib (IMP-4297);Rotundine Impurity 13;Senaparib, 10 mM in DMSO;Senaparib（IMP4297，JS109）;5-Fluoro-1-(4-fluoro-3-(4-(pyrimidin-2-yl)piperazine-1-carbonyl)benzyl)quinazoline-2,4(1H,3H)-dione;inhibit,poly ADP ribose polymerase,IMP 4297,Inhibitor,breast,pancreatic,IMP-4297,Senaparib,PARP,cancer,PCa
- CBNumber
- CB68080026
- Molecular Formula
- C24H20F2N6O3
- Formula Weight
- 478.45
- MOL File
- 1401682-78-7.mol
Senaparib Property
- storage temp.
- Store at -20°C
- solubility
- DMSO : 83.33 mg/mL (174.17 mM; Need ultrasonic)
- form
- Solid
- color
- White to off-white
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- CS-0138656
- Product name
- Senaparib
- Purity
- 99.44%
- Packaging
- 5mg
- Price
- $110
- Updated
- 2021/12/16
- Product number
- CS-0138656
- Product name
- Senaparib
- Purity
- 99.44%
- Packaging
- 10mg
- Price
- $190
- Updated
- 2021/12/16
- Product number
- CS-0138656
- Product name
- Senaparib
- Purity
- 99.44%
- Packaging
- 25mg
- Price
- $350
- Updated
- 2021/12/16
- Product number
- CS-0138656
- Product name
- Senaparib
- Purity
- 99.44%
- Packaging
- 50mg
- Price
- $550
- Updated
- 2021/12/16
- Product number
- CS-0138656
- Product name
- Senaparib
- Purity
- 99.44%
- Packaging
- 100mg
- Price
- $950
- Updated
- 2021/12/16
Senaparib Chemical Properties,Usage,Production
Clinical research
Senaparib is a PARP inhibitor that demonstrated antitumor activity in patients with solid tumours, including ovarian cancer, in phase 1 studies. The multicenter, double-blind, phase 3 trial FLAMES randomized (2:1) 404 females with advanced ovarian cancer (International Federation of Gynecology and Obstetrics stage III–IV) and response to first-line platinum-based chemotherapy to senaparib 100 mg (n = 271) or placebo (n = 133) orally once daily for up to 2 years. The primary endpoint was progression-free survival assessed by a blinded independent central review. At the prespecified interim analysis, the median progression-free survival was not reached with senaparib and was 13.6 months with placebo (hazard ratio 0.43, 95% confidence interval 0.32–0.58; P < 0.0001). The benefit of senaparib over placebo was consistent in the subgroups defined by BRCA1 and BRCA2 mutation or homologous recombination status. Grade ≥3 treatment-emergent adverse events occurred in 179 (66%) and 27 (20%) patients, respectively.
Description
Senaparib is a novel and potent PARP1 inhibitor with a unique chemical structure and high inhibitory activity. Research has found that Senaparib not only effectively inhibits the enzymatic activity of PARP1 and PARP2 but also induces the "trapping" of PARP1 on DNA, leading to the stalling of DNA replication forks and double-strand DNA breaks, ultimately causing cell death. This "trapping" effect is considered a key factor in the therapeutic efficacy of PARP1 inhibitors.
Uses
Senaparib (IMP4297) is a highly potent, selective and orally active PARP1/2 inhibitor. Senaparib (IMP4297) exhibits strong antitumor activity in animal models[1].
References
[1] P. de Souza, et al. 574P Updated results of phase I study of senaparib (IMP4297) in Australian patients with advanced solid tumours. ABSTRACT ONLY| VOLUME 31, SUPPLEMENT 4, S490, SEPTEMBER 01, 2020.
Senaparib Preparation Products And Raw materials
Raw materials
Preparation Products
Senaparib Suppliers
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