Benzoic acid, 4-[3-[2-[[4-(acetylamino)phenyl]thio]acetyl]-2,5-dimethyl-1H-pyrrol-1-yl]-, methyl ester

Product Name: Benzoic acid, 4-[3-[2-[[4-(acetylamino)phenyl]thio]acetyl]-2,5-dimethyl-1H-pyrrol-1-yl]-, methyl ester
CAS No.: 731006-86-3
Chemical Name: Benzoic acid, 4-[3-[2-[[4-(acetylamino)phenyl]thio]acetyl]-2,5-dimethyl-1H-pyrrol-1-yl]-, methyl ester
Synonyms: ML 397;VU0155094;VU0155094(ML-397);VU0155094, 10 mM in DMSO;VU0155094 (Synonyms: ML397);VU0155094,Inhibitor,Metabotropic glutamate receptors,ML397,inhibit,mGluR;Methyl 4-(3-(2-((4-acetamidophenyl)thio)acetyl)-2,5-dimethyl-1H-pyrrol-1-yl)benzoate;methyl 4-(3-{2-[(4-acetamidophenyl)sulfanyl]acetyl}-2,5-dimethyl-1H-pyrrol-1-yl)benzoate;Methyl 4-[3-[2-[[4-(acetylamino)phenyl]thio]acetyl]-2,5-dimethyl-1H-pyrrol-1-yl]benzoate;Benzoic acid, 4-[3-[2-[[4-(acetylamino)phenyl]thio]acetyl]-2,5-dimethyl-1H-pyrrol-1-yl]-, methyl ester
CBNumber: CB68101336
Molecular Formula: C24H24N2O4S
Formula Weight: 436.52
MOL File: 731006-86-3.mol

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Benzoic acid, 4-[3-[2-[[4-(acetylamino)phenyl]thio]acetyl]-2,5-dimethyl-1H-pyrrol-1-yl]-, methyl ester Property

Boiling point:: 667.0±55.0 °C(Predicted)
Density: 1.21±0.1 g/cm3(Predicted)
pka: 14.56±0.70(Predicted)
form: Solid
color: White to light yellow

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Hazard and Precautionary Statements (GHS)

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Benzoic acid, 4-[3-[2-[[4-(acetylamino)phenyl]thio]acetyl]-2,5-dimethyl-1H-pyrrol-1-yl]-, methyl ester Chemical Properties,Usage,Production

Description

ML397, also known as VU0155094, is a positive allosteric modulator. ML397 showed differential activity at the various group III mGlus. Additionally, both compounds show probe dependence when assessed in the presence of distinct orthosteric agonists.

Uses

VU0155094 is a positive allosteric modulator with differential activity at the various group III mGluRs[1].

References

[1] Jalan-Sakrikar N, et al. Identification of positive allosteric modulators VU0155094 (ML397) and VU0422288 (ML396) reveals new insights into the biology of metabotropic glutamate receptor 7. ACS Chem Neurosci. 2014 Dec 17;5(12):1221-37. DOI:10.1021/cn500153z

Benzoic acid, 4-[3-[2-[[4-(acetylamino)phenyl]thio]acetyl]-2,5-dimethyl-1H-pyrrol-1-yl]-, methyl ester Preparation Products And Raw materials

Raw materials

Preparation Products

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Benzoic acid, 4-[3-[2-[[4-(acetylamino)phenyl]thio]acetyl]-2,5-dimethyl-1H-pyrrol-1-yl]-, methyl ester Suppliers

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731006-86-3, Benzoic acid, 4-[3-[2-[[4-(acetylamino)phenyl]thio]acetyl]-2,5-dimethyl-1H-pyrrol-1-yl]-, methyl esterRelated Search:

Benzoic acid, 4-[3-[2-[[4-(acetylamino)phenyl]thio]acetyl]-2,5-dimethyl-1H-pyrrol-1-yl]-, methyl ester

VU0155094

ML 397

VU0155094(ML-397)

Methyl 4-[3-[2-[[4-(acetylamino)phenyl]thio]acetyl]-2,5-dimethyl-1H-pyrrol-1-yl]benzoate

VU0155094 (Synonyms: ML397)

VU0155094,Inhibitor,Metabotropic glutamate receptors,ML397,inhibit,mGluR

Methyl 4-(3-(2-((4-acetamidophenyl)thio)acetyl)-2,5-dimethyl-1H-pyrrol-1-yl)benzoate

methyl 4-(3-{2-[(4-acetamidophenyl)sulfanyl]acetyl}-2,5-dimethyl-1H-pyrrol-1-yl)benzoate

VU0155094, 10 mM in DMSO

731006-86-3