ChemicalBook > CAS DataBase List > BDTX-189

BDTX-189

Product Name: BDTX-189
CAS No.: 2414572-47-5
Chemical Name: BDTX-189
Synonyms: BDTX-189;Bugatinib;Tuxobertinib;BDTX-189 ，S9786;Tuxobertinib (BDTX-189);Tuxobertinib, 10 mM in DMSO;EGFR/HER2 inhibitor BDTX-189;ErbB mutant-specific inhibitor BDTX-189;N-(4-((3-Chloro-4-(pyridin-2-ylmethoxy)phenyl)amino)-7-(2-morpholinoethoxy)quinazolin-6-yl)acrylamide;2-Propenamide, N-[4-[[3-chloro-4-(2-pyridinylmethoxy)phenyl]amino]-7-[2-(4-morpholinyl)ethoxy]-6-quinazolinyl]-
CBNumber: CB68117755
Molecular Formula: C29H29ClN6O4
Formula Weight: 561.03
MOL File: 2414572-47-5.mol

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BDTX-189 Property

Boiling point:: 778.0±60.0 °C(Predicted)
Density: 1.349±0.06 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMSO:22.56(Max Conc. mg/mL);40.21(Max Conc. mM)
DMF:1.0(Max Conc. mg/mL);1.78(Max Conc. mM)
DMF:PBS (pH 7.2) (1:2):0.3(Max Conc. mg/mL);0.53(Max Conc. mM)
form: A solid
pka: 12.20±0.43(Predicted)
color: Off-white to light yellow
InChIKey: HIBPKFXWOPYJPZ-UHFFFAOYSA-N
SMILES: C(NC1C(OCCN2CCOCC2)=CC2C(C=1)=C(NC1=CC=C(OCC3=NC=CC=C3)C(Cl)=C1)N=CN=2)(=O)C=C

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

ChemScene

Product number: CS-0133688
Product name: BDTX-189
Purity: 99.94%
Packaging: 5mg
Price: $450
Updated: 2021/12/16

ChemScene

Product number: CS-0133688
Product name: BDTX-189
Purity: 99.94%
Packaging: 10mg
Price: $750
Updated: 2021/12/16

ChemScene

Product number: CS-0133688
Product name: BDTX-189
Purity: 99.94%
Packaging: 25mg
Price: $1450
Updated: 2021/12/16

ChemScene

Product number: CS-0133688
Product name: BDTX-189
Purity: 99.94%
Packaging: 50mg
Price: $2250
Updated: 2021/12/16

ChemScene

Product number: CS-0133688
Product name: BDTX-189
Purity: 99.94%
Packaging: 100mg
Price: $3350
Updated: 2021/12/16

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BDTX-189 Chemical Properties,Usage,Production

Uses

Tuxobertinib (BDTX-189) is a potent, orally active and selective inhibitor of allosteric EGFR and HER2 oncogenic mutations, including EGFR/HER2 exon 20 insertion mutants. Tuxobertinib shows KDs of 0.2, 0.76, 13 and 1.2 nM for EGFR, HER2, BLK and RIPK2, reapectively. Anticancer activity[1].

in vivo

Tuxobertinib (0-100 mg/kg; p.o.; daily for 15 dyas) shows dose-dependent tumor growth inhibition and regression in in athymic nude mice bearing HER2 S310F Ba/F3 allograft tumors^[1].
? Tuxobertinib (1-50 mg/kg.p.o.; daily for 15 days) shows dose-dependent tumor growth inhibition and regression in athymic nude mice bearing CUTO-14 PDX tumors that express the EGFR mutation EGFR ASV^[1].

IC 50

EGFR: 0.2 nM (Kd); HER2: 0.76 nM (Kd); RIPK2: 1.2 nM (Kd); BLK: 13 nM (Kd)

References

[1] Elizabeth Buck, et al. BDTX-189, a Potent and Selective Inhibitor of Allosteric EGFR and HER2 Oncogenic Mutations.

BDTX-189 Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from BDTX-189 manufacturers

HangZhou RunYan Pharma Technology Co.,LTD.

Product: BDTX-189; Tuxobertinib 2414572-47-5
Price: US $0.00-0.00/MG
Min. Order: 10MG
Purity: 99% HPLC
Supply Ability: 10000
Release date: 2024-09-19

2414572-47-5, BDTX-189Related Search:

BDTX-189

2-Propenamide, N-[4-[[3-chloro-4-(2-pyridinylmethoxy)phenyl]amino]-7-[2-(4-morpholinyl)ethoxy]-6-quinazolinyl]-

Tuxobertinib

Tuxobertinib,inhibit,ErbB-1,EGFR,BDTX 189,BDTX189,mutants,Epidermal growth factor receptor,nude,allosteric,Ba/F3,HER1,oncogene athymic,oral,mice,insertion,Inhibitor

EGFR/HER2 inhibitor BDTX-189

ErbB mutant-specific inhibitor BDTX-189

Tuxobertinib (BDTX-189)

Bugatinib

N-(4-((3-Chloro-4-(pyridin-2-ylmethoxy)phenyl)amino)-7-(2-morpholinoethoxy)quinazolin-6-yl)acrylamide

Tuxobertinib, 10 mM in DMSO

BDTX-189 ，S9786

2414572-47-5

C29H29ClN6O4

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