Benzamide, N-[2-(4-ethoxyphenoxy)phenyl]-4-[[(1-oxo-2-propen-1-yl)amino]methyl]-
- Product Name
- Benzamide, N-[2-(4-ethoxyphenoxy)phenyl]-4-[[(1-oxo-2-propen-1-yl)amino]methyl]-
- CAS No.
- 1197824-15-9
- Chemical Name
- Benzamide, N-[2-(4-ethoxyphenoxy)phenyl]-4-[[(1-oxo-2-propen-1-yl)amino]methyl]-
- Synonyms
- EN4 ，S9807;EN4 MYC inhibitor;EN4, 10 mM in DMSO;4-(Acrylamidomethyl)-N-(2-(4-ethoxyphenoxy)phenyl)benzamide;4-(Acrylamidomethyl)-N-(2-(4-ethoxyphenoxy)phenyl)benzamide , EN4;N-[2-(4-Ethoxyphenoxy)phenyl]-4-[(prop-2-enamido)methyl]benzamide;N-[2-(4-Ethoxyphenoxy)phenyl]-4-[[(1-oxo-2-propen-1-yl)amino]methyl]benzamide;Benzamide, N-[2-(4-ethoxyphenoxy)phenyl]-4-[[(1-oxo-2-propen-1-yl)amino]methyl]-;EN4,ligand,Myc,tumorigenesis,transcriptional,inhibit,Inhibitor,EN 4,covalent,C171,c-Myc,EN-4
- CBNumber
- CB68153724
- Molecular Formula
- C25H24N2O4
- Formula Weight
- 416.47
- MOL File
- 1197824-15-9.mol
Benzamide, N-[2-(4-ethoxyphenoxy)phenyl]-4-[[(1-oxo-2-propen-1-yl)amino]methyl]- Property
- Boiling point:
- 564.1±50.0 °C(Predicted)
- Density
- 1.202±0.06 g/cm3(Predicted)
- storage temp.
- 4°C, protect from light
- solubility
- DMSO : 250 mg/mL (600.28 mM; Need ultrasonic)
- form
- Solid
- pka
- 12.82±0.70(Predicted)
- color
- White to light yellow
- InChI
- 1S/C25H24N2O4/c1-3-24(28)26-17-18-9-11-19(12-10-18)25(29)27-22-7-5-6-8-23(22)31-21-15-13-20(14-16-21)30-4-2/h3,5-16H,1,4,17H2,2H3,(H,26,28)(H,27,29)
- InChIKey
- DKOWGKKELPCHEG-UHFFFAOYSA-N
- SMILES
- O=C(C1=CC=C(CNC(C=C)=O)C=C1)NC2=C(OC3=CC=C(OCC)C=C3)C=CC=C2
Safety
- WGK Germany
- WGK 3
- Storage Class
- 11 - Combustible Solids
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P321Specific treatment (see … on this label).
P330Rinse mouth.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- 33473
- Product name
- EN4
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $72
- Updated
- 2026/04/30
- Product number
- 33473
- Product name
- EN4
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $115
- Updated
- 2026/04/30
- Product number
- 33473
- Product name
- EN4
- Purity
- ≥98%
- Packaging
- 25mg
- Price
- $251
- Updated
- 2026/04/30
- Product number
- 33473
- Product name
- EN4
- Purity
- ≥98%
- Packaging
- 50mg
- Price
- $394
- Updated
- 2026/04/30
Benzamide, N-[2-(4-ethoxyphenoxy)phenyl]-4-[[(1-oxo-2-propen-1-yl)amino]methyl]- Chemical Properties,Usage,Production
Uses
EN4 is a covalent ligand that targets cysteine 171 (C171) of MYC. EN4 is selective for c-MYC over N-MYC and L-MYC. EN4 inhibits MYC transcriptional activity, downregulates MYC targets, and impairs tumorigenesis[1].
Biological Activity
EN4 is a cell penetrant, potent and selective covalent c-MYC inhibitor th at targets cysteine 171 located within a predicted intrinsically disordered region of MYC. EN4 inhibits MYC transcriptional activity, downregulates multiple MYC transcriptional targets, reduces MYC and MAX thermal stability, and impairs tumorigenesis.
in vivo
EN4 (50 mg/kg; intraperitoneal injection; daily; for 3 weeks) treatment significantly attenuated tumor growth in 231MFP breast tumor xenograft mice[1].
| Animal Model: | SCID mice injected with 231MFP breast cancer cells[1] |
| Dosage: | 50 mg/kg |
| Administration: | Intraperitoneal injection; daily; for 3 weeks |
| Result: | Significantly attenuated tumor growth in vivo. |
References
[1] Lydia Boike, et al. Discovery of a Functional Covalent Ligand Targeting an Intrinsically Disordered Cysteine within MYC. Cell Chem Biol. 2021 Jan 21;28(1):4-13.e17. DOI:10.1016/j.chembiol.2020.09.001
Benzamide, N-[2-(4-ethoxyphenoxy)phenyl]-4-[[(1-oxo-2-propen-1-yl)amino]methyl]- Preparation Products And Raw materials
Raw materials
Preparation Products
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