ChemicalBook > CAS DataBase List > 1-Piperazinecarboxylic acid, 4-[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-5-yl]-, 1,1-dimethylethyl ester
1-Piperazinecarboxylic acid, 4-[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-5-yl]-, 1,1-dimethylethyl ester
- Product Name
- 1-Piperazinecarboxylic acid, 4-[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-5-yl]-, 1,1-dimethylethyl ester
- CAS No.
- 2222114-64-7
- Chemical Name
- 1-Piperazinecarboxylic acid, 4-[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-5-yl]-, 1,1-dimethylethyl ester
- Synonyms
- Thalidomide-piperazine-Boc;Thalidomide-5-piperazine-Boc;tert-butyl 4-(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)piperazine-1-carboxylate;1-Piperazinecarboxylic acid, 4-[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-5-yl]-, 1,1-dimethylethyl ester
- CBNumber
- CB68192310
- Molecular Formula
- C22H26N4O6
- Formula Weight
- 442.46
- MOL File
- 2222114-64-7.mol
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1-Piperazinecarboxylic acid, 4-[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-5-yl]-, 1,1-dimethylethyl ester Property
- Boiling point:
- 674.6±55.0 °C(Predicted)
- Density
- 1.373±0.06 g/cm3(Predicted)
- solubility
- DMSO : 41.67 mg/mL (94.18 mM; Need ultrasonic)
- pka
- 10.83±0.40(Predicted)
- form
- Solid
- color
- Light yellow to yellow
- InChI
- InChI=1S/C22H26N4O6/c1-22(2,3)32-21(31)25-10-8-24(9-11-25)13-4-5-14-15(12-13)20(30)26(19(14)29)16-6-7-17(27)23-18(16)28/h4-5,12,16H,6-11H2,1-3H3,(H,23,27,28)
- InChIKey
- PMKVKOLFYHLKAP-UHFFFAOYSA-N
- SMILES
- N1(C(OC(C)(C)C)=O)CCN(C2C=CC3=C(C=2)C(=O)N(C2CCC(=O)NC2=O)C3=O)CC1
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1-Piperazinecarboxylic acid, 4-[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-5-yl]-, 1,1-dimethylethyl ester Chemical Properties,Usage,Production
Uses
Thalidomide-piperazine-Boc is an intermediate that can be used in the synthesis of B-cell lymphoma 6 protein (BCL6) PROTAC[1].
Biological Activity
Thalidomide-piperazine-Boc is an intermediate that can be used in the synthesis of B-cell lymphoma 6 protein (BCL6) PROTAC[1].
IC 50
Cereblon
References
[1]. Michael Berlin, et al. Bifunctional molecules containing an e3 ubiquitine ligase binding moiety linked to a bcl6 targeting moiety. WO2021077010A1.
1-Piperazinecarboxylic acid, 4-[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-5-yl]-, 1,1-dimethylethyl ester Preparation Products And Raw materials
Raw materials
Preparation Products
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1-Piperazinecarboxylic acid, 4-[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-5-yl]-, 1,1-dimethylethyl ester Suppliers
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2222114-64-7, 1-Piperazinecarboxylic acid, 4-[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-5-yl]-, 1,1-dimethylethyl esterRelated Search:
1-Piperidinecarboxylic acid, 3-(4-hydroxyphenyl)-2,6-dioxo-, 1,1-dimethylethyl ester
Tert-butyl 4-(4-aMino-3-Methoxyphenyl)piperazine-1-carboxylate
tert-butyl (S)-3-(cyanomethyl)piperazine-1-carboxylate
1-Piperidinecarboxylic acid, 3-(4-amino-1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)-2,6-dioxo-, 1,1-dimethylethyl ester
tert-Butyl 2,6-dioxo-3-(4-(prop-2-yn-1-yloxy)phenyl)piperidine-1-carboxylate
4-[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]-, 1,1-dimethylethyl ester-1-Piperazinecarboxylic acid,
1-Piperidinecarboxylic acid, 4-[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1-oxo-1H-isoindol-5-yl]-, 1,1-dimethylethyl ester
4-[2-(2,6-dioxo-3-piperidinyl)-6-fluoro-2,3-dihydro-1,3-dioxo-1Hisoindol-5-yl]-, 1,1-dimethylethyl ester-1-Piperazinecarboxylic acid,
4H-Pyrazolo[1,5-a][1,4]diazepine-5(6H)-carboxylic acid, 7,8-dihydro-3-iodo-, 1,1-dimethylethyl ester
tert-butyl 4-((7-tosyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)piperidine-1-carboxylate
1-Piperazinecarboxylic acid, 4-[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1-oxo-1H-isoindol-5-yl]-, 1,1-dimethylethyl ester