5-BROMO-2,3-DIFLUORO-BENZALDEHYDE
- Product Name
- 5-BROMO-2,3-DIFLUORO-BENZALDEHYDE
- CAS No.
- 633327-22-7
- Chemical Name
- 5-BROMO-2,3-DIFLUORO-BENZALDEHYDE
- Synonyms
- 108671;5-BROMO-2,3-DIFLUORO-BENZALDEHYDE;Benzaldehyde, 5-bromo-2,3-difluoro-
- CBNumber
- CB6821254
- Molecular Formula
- C7H3BrF2O
- Formula Weight
- 221
- MOL File
- Mol file
5-BROMO-2,3-DIFLUORO-BENZALDEHYDE Property
- Boiling point:
- 230.0±35.0 °C(Predicted)
- Density
- 1.758±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2–8 °C
- form
- fused solid
- color
- Colourless/white
- InChI
- InChI=1S/C7H3BrF2O/c8-5-1-4(3-11)7(10)6(9)2-5/h1-3H
- InChIKey
- WNJTWTDADQWUFR-UHFFFAOYSA-N
- SMILES
- C(=O)C1=CC(Br)=CC(F)=C1F
Safety
- HS Code
- 2913000090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P330Rinse mouth.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
P403+P233Store in a well-ventilated place. Keep container tightly closed.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- B700385
- Product name
- 5-Bromo-2,3-difluorobenzaldehyde
- Packaging
- 50mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- 2615-B-33
- Product name
- 5-Bromo-2,3-difluorobenzaldehyde
- Purity
- 96%
- Packaging
- 1g
- Price
- $109
- Updated
- 2021/12/16
- Product number
- 2615-B-33
- Product name
- 5-Bromo-2,3-difluorobenzaldehyde
- Purity
- 96%
- Packaging
- 5G
- Price
- $384
- Updated
- 2021/12/16
- Product number
- HCH0352387
- Product name
- 5-BROMO-2,3-DIFLUOROBENZALDEHYDE
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $505.53
- Updated
- 2021/12/16
- Product number
- 2615-B-33
- Product name
- 5-Bromo-2,3-difluorobenzaldehyde
- Purity
- 96%
- Packaging
- 10g
- Price
- $656
- Updated
- 2021/12/16
5-BROMO-2,3-DIFLUORO-BENZALDEHYDE Chemical Properties,Usage,Production
Synthesis
2646-91-5
633327-22-7
Under stirring conditions, 2,3-difluorobenzaldehyde (XVIII) (75.0 g, 528 mmol, 1.0 eq.) was dissolved in concentrated sulfuric acid (565 mL) and heated to 60°C. The mixture was then dissolved in a mixture of 2,3-difluorobenzaldehyde (XVIII) and 2,3-difluorobenzaldehyde (XVIII). Subsequently, N-bromosuccinimide (NBS) (113 g, 633 mmol, 1.2 eq.) was added in batches. The reaction mixture was stirred continuously at 60 °C for 12 h. The completion of the reaction was confirmed by LC/MS monitoring. The reaction mixture was slowly poured into a mixture of ice water (500 mL) and petroleum ether (500 mL) and stirred for 10 min before separating the organic layer. The organic layer was concentrated under reduced pressure to give the crude product. The crude product was purified by silica gel column chromatography (eluent: 100% petroleum ether) to afford 5-bromo-2,3-difluorobenzaldehyde (XIX) (120 g, 543.0 mmol, quantitative yield). The product was analyzed by electrospray ionization mass spectrometry (ESIMS) and the molecular formula was confirmed as C7H3BrF2O, m/z 221.1 ([M+H]+).
References
[1] Patent: WO2017/24021, 2017, A1. Location in patent: Paragraph 0616; 0617
[2] Patent: WO2017/24013, 2017, A1. Location in patent: Paragraph 0616; 0617
[3] Patent: WO2017/24010, 2017, A1. Location in patent: Paragraph 0616; 001
[4] Patent: WO2017/23986, 2017, A1. Location in patent: Paragraph 0620; 0621
[5] Patent: US2016/75701, 2016, A1. Location in patent: Paragraph 0812; 0813
5-BROMO-2,3-DIFLUORO-BENZALDEHYDE Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 5-BROMO-2,3-DIFLUORO-BENZALDEHYDE manufacturers
- Product
- 5-BROMO-2,3-DIFLUORO-BENZALDEHYDE 633327-22-7
- Price
- US $7.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 1000kg
- Release date
- 2020-01-13