ChemicalBook > CAS DataBase List > 2-[(3,4-DICHLOROPHENYL)AMINO]-1,4-DIHYDRO-6-NITRO-4-OXO-N-2-PROPENYL-8-QUINAZOLINECARBOXAMIDE
2-[(3,4-DICHLOROPHENYL)AMINO]-1,4-DIHYDRO-6-NITRO-4-OXO-N-2-PROPENYL-8-QUINAZOLINECARBOXAMIDE
- Product Name
- 2-[(3,4-DICHLOROPHENYL)AMINO]-1,4-DIHYDRO-6-NITRO-4-OXO-N-2-PROPENYL-8-QUINAZOLINECARBOXAMIDE
- CAS No.
- 331645-84-2
- Chemical Name
- 2-[(3,4-DICHLOROPHENYL)AMINO]-1,4-DIHYDRO-6-NITRO-4-OXO-N-2-PROPENYL-8-QUINAZOLINECARBOXAMIDE
- Synonyms
- AQZ-1;AZ 10417808;2-[(3,4-DICHLOROPHENYL)AMINO]-1,4-DIHYDRO-6-NITRO-4-OXO-N-2-PROPENYL-8-QUINAZOLINECARBOXAMIDE;8-Quinazolinecarboxamide, 2-[(3,4-dichlorophenyl)amino]-3,4-dihydro-6-nitro-4-oxo-N-2-propen-1-yl-
- CBNumber
- CB6829694
- Molecular Formula
- C18H13Cl2N5O4
- Formula Weight
- 434.23
- MOL File
- 331645-84-2.mol
More
Less
2-[(3,4-DICHLOROPHENYL)AMINO]-1,4-DIHYDRO-6-NITRO-4-OXO-N-2-PROPENYL-8-QUINAZOLINECARBOXAMIDE Property
- storage temp.
- Store at RT
- solubility
- <10.86mg/ml in DMSO
- form
- solid
- color
- Yellow
More
Less
N-Bromosuccinimide Price
TRC
- Product number
- A808213
- Product name
- AZ10417808
- Packaging
- 2.5mg
- Price
- $250
- Updated
- 2021/12/16
ApexBio Technology
- Product number
- A4416
- Product name
- AZ10417808
- Packaging
- 5mg
- Price
- $322
- Updated
- 2021/12/16
American Custom Chemicals Corporation
- Product number
- HCH0351637
- Product name
- 2-[(3,4-DICHLOROPHENYL)AMINO]-1,4-DIHYDRO-6-NITRO-4-OXO-N-2-PROPENYL-8-QUINAZOLINECARBOXAMIDE
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $497.35
- Updated
- 2021/12/16
More
Less
2-[(3,4-DICHLOROPHENYL)AMINO]-1,4-DIHYDRO-6-NITRO-4-OXO-N-2-PROPENYL-8-QUINAZOLINECARBOXAMIDE Chemical Properties,Usage,Production
Uses
AZ 10417808 inhibits human caspase-3 with Ki values in the 90 to 800 nM range. AZ 10417808 blocks cellular and biochemical features of apoptosis in cells.
Definition
ChEBI: 2-(3,4-dichloroanilino)-6-nitro-4-oxo-N-prop-2-enyl-1H-quinazoline-8-carboxamide is a member of quinazolines.
Biological Activity
Selective non-peptide inhibitor of caspase-3 (K i = 247 nM); displays > 40-fold selectivity over caspases 1, 2, 6, 7 and 8 (K i > 10 μ M). Completely blocks staurosporine-induced intracellular DEVDase activity in SH-SY5Y cells (IC 50 = 14.9 μ M).
2-[(3,4-DICHLOROPHENYL)AMINO]-1,4-DIHYDRO-6-NITRO-4-OXO-N-2-PROPENYL-8-QUINAZOLINECARBOXAMIDE Preparation Products And Raw materials
Raw materials
Preparation Products
More
Less
2-[(3,4-DICHLOROPHENYL)AMINO]-1,4-DIHYDRO-6-NITRO-4-OXO-N-2-PROPENYL-8-QUINAZOLINECARBOXAMIDE Suppliers
- Tel
- 821-50328103-801 18930552037
- Fax
- 86-21-50328109
- 3bsc@sina.com
- Country
- China
- ProdList
- 15848
- Advantage
- 69
- Tel
- 1-631-485-4226; 16314854226
- info@bocsci.com
- Country
- United States
- ProdList
- 14059
- Advantage
- 65
- Tel
- +1 (866) 930-6790
- Fax
- +1 (866) 333-9607
- info@adooq.com
- Country
- United States
- ProdList
- 2784
- Advantage
- 58
- Tel
- 888-539-0666
- Fax
- 888-539-0666
- info@emmx.com
- Country
- United States
- ProdList
- 8449
- Advantage
- 60
- Tel
- 15971444841
- Fax
- 18327183813
- amber@biochempartner.com
- Country
- China
- ProdList
- 3063
- Advantage
- 58
- Tel
- 021-38015121 15000105423
- chenjw@absin.cn
- Country
- China
- ProdList
- 24734
- Advantage
- 58
- Tel
- 021-69568360 18916172912
- order@med-bio.cn
- Country
- China
- ProdList
- 8141
- Advantage
- 58
- Tel
- 0519-85524369
- 3477467573@qq.com
- Country
- China
- ProdList
- 8618
- Advantage
- 58
- Tel
- +86-852-30606658
- market18@leapchem.com
- Country
- China
- ProdList
- 43348
- Advantage
- 58
331645-84-2, 2-[(3,4-DICHLOROPHENYL)AMINO]-1,4-DIHYDRO-6-NITRO-4-OXO-N-2-PROPENYL-8-QUINAZOLINECARBOXAMIDERelated Search:
N-O-TOLYL-GUANIDINE
6-NITROQUINAZOLIN-4(3H)-ONE
N-(3,4-Dichlorophenyl)guanidine
3-(AMINOMETHYL)-N-METHYLBENZAMIDE HYDROCHLORIDE
2-[(3,4-DICHLOROPHENYL)AMINO]-1,4-DIHYDRO-6-NITRO-4-OXO-N-2-PROPENYL-8-QUINAZOLINECARBOXAMIDE
6-AMINO-3H-QUINAZOLIN-4-ONE
1,3-Diphenylguanidine