7-Methoxyindazole
- Product Name
- 7-Methoxyindazole
- CAS No.
- 133841-05-1
- Chemical Name
- 7-Methoxyindazole
- Synonyms
- 7-methoxyindazole;7-METHOXY-1H-INDAZOLE;1H-Indazole, 7-methoxy-;7-methoxy-1H-indazole-3-carbonyl chloride
- CBNumber
- CB6830513
- Molecular Formula
- C8H8N2O
- Formula Weight
- 148.16
- MOL File
- 133841-05-1.mol
7-Methoxyindazole Property
- Melting point:
- 91-92 °C
- Boiling point:
- 312.5±15.0 °C(Predicted)
- Density
- 1.244±0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- form
- solid
- pka
- 13.33±0.40(Predicted)
- color
- Brown
Safety
- HS Code
- 2933998090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- M263460
- Product name
- 7-Methoxy-1H-indazole
- Packaging
- 10g
- Price
- $1025
- Updated
- 2021/12/16
- Product number
- CHM0068452
- Product name
- 1H-INDAZOLE, 7-METHOXY
- Purity
- 95.00%
- Packaging
- 1G
- Price
- $1085.42
- Updated
- 2021/12/16
- Product number
- Y7436
- Product name
- 7-Methoxy-1H-indazole
- Packaging
- 25g
- Price
- $2886
- Updated
- 2021/12/16
- Product number
- 225680
- Product name
- 7-Methoxy-1H-indazole
- Purity
- 95+%
- Packaging
- 250mg
- Price
- $89
- Updated
- 2021/12/16
- Product number
- Y7436
- Product name
- 7-Methoxy-1H-indazole
- Packaging
- 250mg
- Price
- $162
- Updated
- 2021/12/16
7-Methoxyindazole Chemical Properties,Usage,Production
Uses
7-Methoxy-1H-indazole is an inhibitor of neuronal nitric oxide synthase.
Synthesis
50868-76-3
133841-05-1
GENERAL STEPS: To a solution of N-(2-methoxy-6-methylphenyl)acetamide (9.28 g, 51.8 mmol) in ethyl acetate (100 mL) was added sequentially acetic anhydride (14.7 mL, 156 mmol), tetrabutylammonium bromide (0.84 g, 2.61 mmol), potassium acetate (10.16 g, 104 mmol), and isoamyl nitrite ( 9.1 mL, 67.7 mmol). The reaction mixture was heated to reflux for 9 hours. Upon completion of the reaction, the solvent was removed by distillation under reduced pressure. To the residue, 6 N aqueous sodium hydroxide solution (100 mL) was added and stirred for 1 h at room temperature. Subsequently, the pH of the mixture was adjusted to 7-8 with 3 N hydrochloric acid and extracted with chloroform. The organic layers were combined, dried with anhydrous magnesium sulfate and concentrated under reduced pressure. The resulting crude product was purified by silica gel column chromatography (eluent: n-hexane/ethyl acetate = 3/1→1/1) to afford 7-methoxy-1H-indazole (3.95 g, 51% yield).1H-NMR (DMSO-d6) δ: 3.94 (3H, s), 6.82 (1H, d, J = 7.5 Hz), 7.02 (1H, dd, J = 8.0, 7.5 Hz), 7.30 (1H, d, J = 8.0 Hz), 8.01 (1H, d, J = 1.5 Hz), 13.27 (brs, 1H).
References
[1] Patent: EP1514869, 2005, A1. Location in patent: Page/Page column 83
[2] Journal of the American Chemical Society, 1954, vol. 76, p. 1176
7-Methoxyindazole Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 7-Methoxyindazole manufacturers
- Product
- 7-METHOXY-1H-INDAZOLE 133841-05-1
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 200kg
- Release date
- 2019-12-30