Urea, N-(4-chloro-3-nitrophenyl)-N'-(4-fluorophenyl)-

Product Name: Urea, N-(4-chloro-3-nitrophenyl)-N'-(4-fluorophenyl)-
CAS No.: 897326-30-6
Chemical Name: Urea, N-(4-chloro-3-nitrophenyl)-N'-(4-fluorophenyl)-
Synonyms: DTHIB;DTHIB, 10 mM in DMSO;1-(4-Chloro-3-nitrophenyl)-3-(4-fluorophenyl)urea;N-(4-Chloro-3-nitrophenyl)-N′-(4-fluorophenyl)urea;Urea, N-(4-chloro-3-nitrophenyl)-N'-(4-fluorophenyl)-;degradation,HSP27,Inhibitor,inhibit,HSP70,HSF1,HSP,DTHIB,HSP90,cancer,nuclear,anticancer,Heat shock proteins,prostate
CBNumber: CB68344993
Molecular Formula: C13H9ClFN3O3
Formula Weight: 309.68
MOL File: 897326-30-6.mol

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Urea, N-(4-chloro-3-nitrophenyl)-N'-(4-fluorophenyl)- Property

Boiling point:: 347.2±42.0 °C(Predicted)
Density: 1.565±0.06 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMSO : 100 mg/mL (322.91 mM; Need ultrasonic)
form: Solid
pka: 12.61±0.70(Predicted)
color: Light yellow to yellow

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Axon Medchem

Product number: Axon3412
Product name: DTHIB
Purity: 99%
Packaging: 10mg
Price: $99
Updated: 2021/12/16

ChemScene

Product number: CS-0146732
Product name: DTHIB
Purity: 98.34%
Packaging: 5mg
Price: $150
Updated: 2021/12/16

ChemScene

Product number: CS-0146732
Product name: DTHIB
Purity: 98.34%
Packaging: 10mg
Price: $250
Updated: 2021/12/16

ChemScene

Product number: CS-0146732
Product name: DTHIB
Purity: 98.34%
Packaging: 25mg
Price: $450
Updated: 2021/12/16

ChemScene

Product number: CS-0146732
Product name: DTHIB
Purity: 98.34%
Packaging: 50mg
Price: $750
Updated: 2021/12/16

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Urea, N-(4-chloro-3-nitrophenyl)-N'-(4-fluorophenyl)- Chemical Properties,Usage,Production

Uses

DTHIB is a direct and selective heat shock factor 1 (HSF1) inhibitor with a Kd of 160 nM for DTHIB binding to the HSF1 DNA binding domain (DBD). DTHIB inhibits HSF1 cancer gene signature (HSF1 CaSig) and selectively stimulates degradation of nuclear HSF1. DTHIB has potently anticancer activities and can be used for prostate cancer research[1].

in vivo

DTHIB (5 mg/kg; intraperitoneal injection; daily; for 3 weeks) treatment potently attenuates tumor progression in a C4-2 xenograft mouse model^[1].

Animal Model:	Nude mice (6 weeks of age) injected with C4-2 cells^[1]
Dosage:	5 mg/kg
Administration:	Intraperitoneal injection; daily; for 3 weeks
Result:	Showed no visible tumor growth over a 3-week period and a 40% reduction in median tumor volume.

References

[1] Bushu Dong, et al. Targeting therapy-resistant prostate cancer via a direct inhibitor of the human heat shock transcription factor 1. Sci Transl Med. 2020 Dec 16;12(574):eabb5647. DOI:10.1126/scitranslmed.abb5647

Urea, N-(4-chloro-3-nitrophenyl)-N'-(4-fluorophenyl)- Preparation Products And Raw materials

Raw materials

Preparation Products

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Urea, N-(4-chloro-3-nitrophenyl)-N'-(4-fluorophenyl)- Suppliers

China 43 United States 4 Global 47

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897326-30-6, Urea, N-(4-chloro-3-nitrophenyl)-N'-(4-fluorophenyl)-Related Search:

Urea, N-(4-chloro-3-nitrophenyl)-N'-(4-fluorophenyl)-

DTHIB

1-(4-Chloro-3-nitrophenyl)-3-(4-fluorophenyl)urea

degradation,HSP27,Inhibitor,inhibit,HSP70,HSF1,HSP,DTHIB,HSP90,cancer,nuclear,anticancer,Heat shock proteins,prostate

DTHIB, 10 mM in DMSO

N-(4-Chloro-3-nitrophenyl)-N′-(4-fluorophenyl)urea

897326-30-6