ChemicalBook > CAS DataBase List > 2-Propanol, 1-[bis(phenylmethyl)amino]-3-[4-(trifluoromethyl)phenoxy]-

2-Propanol, 1-[bis(phenylmethyl)amino]-3-[4-(trifluoromethyl)phenoxy]-

Product Name: 2-Propanol, 1-[bis(phenylmethyl)amino]-3-[4-(trifluoromethyl)phenoxy]-
CAS No.: 2222094-18-8
Chemical Name: 2-Propanol, 1-[bis(phenylmethyl)amino]-3-[4-(trifluoromethyl)phenoxy]-
Synonyms: BC-1618;BC1618, 10 mM in DMSO;1-(Dibenzylamino)-3-(4-(trifluoromethyl)phenoxy)propan-2-ol;2-Propanol, 1-[bis(phenylmethyl)amino]-3-[4-(trifluoromethyl)phenoxy]-;Ubiquitin activating enzyme,Mitochondrial Autophagy,fission,Mitophagy,inhibit,Inhibitor,mTORC,Ubiquitin ligase,E1 activating enzyme,AMP-activated protein kinase,BC1618,BC 1618,Ubiquitin conjugating enzyme,AMPK,Fbxo48,LPS,E1/E2/E3 Enzyme,metformin,E3 ligating enzyme,pAmpk,pS6,mitochondrial,insulin,BC-1618,E2 conjugating enzyme
CBNumber: CB68358419
Molecular Formula: C24H24F3NO2
Formula Weight: 415.45
MOL File: 2222094-18-8.mol

Less

2-Propanol, 1-[bis(phenylmethyl)amino]-3-[4-(trifluoromethyl)phenoxy]- Property

Boiling point:: 518.8±50.0 °C(Predicted)
Density: 1.223±0.06 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMSO : 100 mg/mL (240.70 mM; Need ultrasonic)|
form: A solid
pka: 13.68±0.20(Predicted)
color: White to off-white
Water Solubility: Water : < 0.1 mg/mL (insoluble)
InChI: InChI=1S/C24H24F3NO2/c25-24(26,27)21-11-13-23(14-12-21)30-18-22(29)17-28(15-19-7-3-1-4-8-19)16-20-9-5-2-6-10-20/h1-14,22,29H,15-18H2
InChIKey: LGTYABNNHILKHF-UHFFFAOYSA-N
SMILES: C(N(CC1=CC=CC=C1)CC1=CC=CC=C1)C(O)COC1=CC=C(C(F)(F)F)C=C1

Less

Hazard and Precautionary Statements (GHS)

Less

N-Bromosuccinimide Price

ChemScene

Product number: CS-0146843
Product name: BC1618
Purity: 99.83%
Packaging: 5mg
Price: $200
Updated: 2021/12/16

ChemScene

Product number: CS-0146843
Product name: BC1618
Purity: 99.83%
Packaging: 10mg
Price: $350
Updated: 2021/12/16

ChemScene

Product number: CS-0146843
Product name: BC1618
Purity: 99.83%
Packaging: 25mg
Price: $650
Updated: 2021/12/16

ChemScene

Product number: CS-0146843
Product name: BC1618
Purity: 99.83%
Packaging: 50mg
Price: $950
Updated: 2021/12/16

ChemScene

Product number: CS-0146843
Product name: BC1618
Purity: 99.83%
Packaging: 100mg
Price: $1350
Updated: 2021/12/16

Less

2-Propanol, 1-[bis(phenylmethyl)amino]-3-[4-(trifluoromethyl)phenoxy]- Chemical Properties,Usage,Production

Uses

Biological Activity

BC1618, an orally active Fbxo48 inhibitory compound, stimulates Ampk-dependent signaling (via preventing activated pAmpkα from Fbxo48-mediated degradation). BC1618 promotes mitochondrial fission, facilitates autophagy and improves hepatic insulin sensitivity[1]. BC1618 enhances pAmpkα protein stability during CHX treatment[1].BC1618 displays more than 1,000-fold enhanced activity to stimulate pAmpkα in cells than metformin[1].BC1618 (0.1-2 μM, 16 h) induced dose- and time-dependent increases in pAmpkα and pACC protein levels are also confirmed in human primary-like hepatocytes[1].BC1618 (1 μM) effectively disrupts the interaction between Fbxo48 and pAmpkα, and has no effect on Fbxo48, Ampkα1 or Ampkα2 messenger RNAs[1].BC1618 increases the abundance of a series of autophagic marker proteins during glucose depletion. BC1618 induces phosphorylation of the mTORC1 associated protein Raptor, reducing pS6 levels, all consistent with the known mTOR inhibitory effects exerted by activated Ampk[1]. BC1618 promotes mitochondrial fission, facilitates autophagy and improves hepatic insulin sensitivity in high-fat-diet-induced obese mice[1].BC1618, appears to be ~1,000-fold more potent than metformin and is extremely well tolerated in mice[1].BC1618 displays excellent oral bioavailability with a peak of 2,000 ng/mL within 0.5h and 500 ng/mL in plasma at 4h after an oral load of 20mg/kg[1].

in vivo

BC1618 promotes mitochondrial fission, facilitates autophagy and improves hepatic insulin sensitivity in high-fat-diet-induced obese mice^[1].
BC1618, appears to be ~1,000-fold more potent than metformin and is extremely well tolerated in mice^[1].
BC1618 displays excellent oral bioavailability with a peak of 2,000 ng/mL within 0.5h and 500 ng/mL in plasma at 4h after an oral load of 20mg/kg^[1].

Animal Model:	C57BL/6 mice^[1].
Dosage:	2 or 10 mg/kg (challenged with LPS (3 mg/kg) for an additional 18 h).
Administration:	IP, once.
Result:	Reduced lung inflammation in endotoxin treated mice.

Animal Model:	C57BL/6 mice^[1].
Dosage:	15 and 30 mg/kg/d.
Administration:	Drinking water for 3 months.
Result:	Exhibited no obvious toxicity.

References

[1]. Yuan Liu, et al. A Fbxo48 inhibitor prevents pAMPKα degradation and ameliorates insulin resistance. Nat Chem Biol. 2021 Mar;17(3):298-306.

2-Propanol, 1-[bis(phenylmethyl)amino]-3-[4-(trifluoromethyl)phenoxy]- Preparation Products And Raw materials

Raw materials

Preparation Products

Less

2-Propanol, 1-[bis(phenylmethyl)amino]-3-[4-(trifluoromethyl)phenoxy]- Suppliers

China 45 United States 6 Global 51

DC Chemicals

Tel: 021-58447131 13564518121
Email: doncunbiosci@gmail.com
Country: China
ProdList: 544
Advantage: 58

ShangHai Caerulum Pharma Discovery Co., Ltd.

Tel: 18149758185
Email: sales-cpd@caerulumpharma.com
Country: China
ProdList: 3506
Advantage: 58

Shanghai Lollane Biological Technology Co.,Ltd.

Tel: 021-52996696，15000506266 15000506266
Fax: +86-21-52996696
Country: China
ProdList: 4768
Advantage: 55

Shanghai Beckham Medical Technology Co., Ltd

Tel: 13816613772
Fax: QQ: 12922499
Email: huahero21@sina.com
Country: China
ProdList: 2391
Advantage: 55

Shanghai EFE Biological Technology Co., Ltd.

Tel: 021-65675885 18964387627
Fax: 021-65675885
Email: info@efebio.com
Country: China
ProdList: 9803
Advantage: 58

Shanghai YuanYe Biotechnology Co., Ltd.

Tel: 021-61312847; 18021002903
Fax: QQ:3008007432
Email: 3008007409@qq.com
Country: China
ProdList: 71826
Advantage: 60

Tianjin Kailiqi Biotechnology Co., Ltd.

Tel: 15076683720
Fax: 022-23754520
Email: klq@cw-bio.com
Country: China
ProdList: 8011
Advantage: 55

ShangHai Biochempartner Co.,Ltd

Tel: 177-54423994 17754423994
Fax: QQ:2853530913
Email: 2853530910@QQ.com
Country: China
ProdList: 8000
Advantage: 62

Shanghai Rechem science Co., Ltd.

Tel: 021-31433387 15618786686
Fax: QQ:1369748377
Email: sales@rechemscience.com
Country: China
ProdList: 2990
Advantage: 58

Shanghai Chaolan Chemical Technology Center

Tel: 021-QQ：65489617 15618227136
Fax: 21-5161 9052
Email: Sales@ATKchemical.com
Country: China
ProdList: 9125
Advantage: 58

Shanghai Yu Ben Biotechnology Co., Ltd.

Tel: 021-61350663 15502154572
Fax: -
Email: 1639466865@qq.com
Country: China
ProdList: 498
Advantage: 58

Shanghai Dongyang Biotechnology Co., Ltd.

Tel: 0512-0512-13601744364 13601744364
Email: chemsharker@126.com
Country: China
ProdList: 1010
Advantage: 58

Jinan Jiuli Biotechnology Co. , Ltd.

Tel: 15865264761
Email: 486064515@qq.com
Country: China
ProdList: 4809
Advantage: 58

Bide Pharmatech Ltd.

Tel: 400-1647117 13681763483
Email: product02@bidepharm.com
Country: China
ProdList: 59936
Advantage: 58

InvivoChem

Tel: 13549236410
Email: sales@invivochem.cn
Country: China
ProdList: 6753
Advantage: 58

TargetMol Chemicals Inc.

Tel: 4008200310
Email: marketing@tsbiochem.com
Country: China
ProdList: 24961
Advantage: 58

Shanghai Yiyan Biotechnology Co. , Ltd.

Tel: 021-69985186 13611928337
Email: 3427709316@qq.com
Country: China
ProdList: 7982
Advantage: 58

https://hanhongsci.com/

Tel: 021-54306202 18917919676
Email: info@hanhongsci.com
Country: China
ProdList: 29995
Advantage: 58

Shanghai?Medlife?Pharm-Tech?Co.,?Ltd

Tel: 021-59167510 18117107507
Email: vip@med-life.cn
Country: China
ProdList: 5002
Advantage: 58

Hangzhou Bingochem Co., Ltd.

Tel: 0571-8512-5372
Email: sales@bingochem.com
Country: China
ProdList: 21669
Advantage: 58

Nanjing Shizhou Biology Technology Co.,Ltd

Tel: 025-85560043 15850508050
Fax: 025-85563444
Email: cindy.huang@synzest.com
Country: China
ProdList: 12000
Advantage: 58

Shanghai Aladdin Biochemical Technology Co.,Ltd.

Tel: 400-6206333 13167063860
Email: anhua.mao@aladdin-e.com
Country: China
ProdList: 48457
Advantage: 58

Shanghai jerryxing Biomedical Technology Co., Ltd

Tel: 17721492509; 17721492509
Email: 643638326@qq.com
Country: China
ProdList: 4970
Advantage: 58

Hubei wei shi reagent group ltd., company

Tel: 027-59101766 13125137661
Email: 2853877621@qq.com
Country: China
ProdList: 7979
Advantage: 58

RD International Technology Co., Limited

Tel: 18024082417
Email: market@ubiochem.com
Country: China
ProdList: 9835
Advantage: 58

Jiangsu Aikon Biopharmaceutical R&D Co.,Ltd

Tel: 025-58851090 17714375163
Email: 2881759498@qq.com
Country: China
ProdList: 13011
Advantage: 58

Sangon Biotech (Shanghai) Co.,Ltd.

Tel: 400-821-026
Email: Sales@sangon.com
Country: China
ProdList: 6710
Advantage: 58

Cayman Chemical Company

Tel: 800-364-9897
Email: sales@caymanchem.com
Country: China
ProdList: 6838
Advantage: 58

Biosynth Biological Technology (Suzhou) Co Ltd

Tel: 51288865780
Email: sales@biosynth.com
Country: China
ProdList: 6051
Advantage: 58

Selleck Chemicals

Tel: 400-668-6834
Email: info@selleck.cn
Country: China
ProdList: 6071
Advantage: 58

ATK CHEMICAL COMPANY LIMITED

Tel: +undefined-21-51877795
Fax: +86 21 5161 9052/ 5187 7796
Email: ivan@atkchemical.com
Country: China
ProdList: 33024
Advantage: 60

HANGZHOU LEAP CHEM CO., LTD.

Tel: +86-571-87711850
Email: market18@leapchem.com
Country: China
ProdList: 24727
Advantage: 58

Guangzhou Chuangze Biotechnology Co., Ltd.

Tel: 18312220236
Country: CHINA
ProdList: 178
Advantage: 58

Guangzhou Suyan Biotechnology Co., Ltd

Tel: 18818417021
Country: CHINA
ProdList: 127
Advantage: 58

Guangzhou Yiran Biotechnology Co., Ltd.

Tel: 15571990006
Country: CHINA
ProdList: 141
Advantage: 58

Guangzhou Baide Biotechnology Co., Ltd.

Tel: 18925065404
Country: CHINA
ProdList: 168
Advantage: 58

Chongqing Aoyi Biotechnology Co., Ltd.

Tel: 13102311730,18585291730
Country: CHINA
ProdList: 140
Advantage: 58

Guangzhou Squirrel Biotechnology Co., Ltd.

Tel: 17765276361
Country: CHINA
ProdList: 109
Advantage: 58

Guangzhou Kegou Biotechnology Co., Ltd.

Tel: 18689410811
Country: CHINA
ProdList: 178
Advantage: 58

Beijing Boning Biotechnology Co., Ltd.

Tel: 13269979963
Email: 1565439254@qq.com
Country: CHINA
ProdList: 195
Advantage: 58

Guangzhou Yansai Biological Products Co., Ltd.

Tel: 13710209565
Country: CHINA
ProdList: 122
Advantage: 58

Biorbyt Ltd.

Tel: --
Fax: --
Email: info@biorbyt.com
Country: CHINA
ProdList: 6482
Advantage: 58

Neobioscience Co., Ltd.

Tel: --
Fax: --
Email: info@neobioscience.com
Country: CHINA
ProdList: 6207
Advantage: 58

Absin Bioscience Inc.

Tel: --
Fax: --
Email: chenjw@absin.cn
Country: CHINA
ProdList: 6208
Advantage: 58

Proteintech China

Tel: --
Fax: --
Email: Proteintech-CN@ptglab.com
Country: CHINA
ProdList: 6290
Advantage: 58

2222094-18-8, 2-Propanol, 1-[bis(phenylmethyl)amino]-3-[4-(trifluoromethyl)phenoxy]-Related Search:

2-Propanol, 1-[bis(phenylmethyl)amino]-3-[4-(trifluoromethyl)phenoxy]-

BC-1618

Ubiquitin activating enzyme,Mitochondrial Autophagy,fission,Mitophagy,inhibit,Inhibitor,mTORC,Ubiquitin ligase,E1 activating enzyme,AMP-activated protein kinase,BC1618,BC 1618,Ubiquitin conjugating enzyme,AMPK,Fbxo48,LPS,E1/E2/E3 Enzyme,metformin,E3 ligating enzyme,pAmpk,pS6,mitochondrial,insulin,BC-1618,E2 conjugating enzyme

1-(Dibenzylamino)-3-(4-(trifluoromethyl)phenoxy)propan-2-ol

BC1618, 10 mM in DMSO

2222094-18-8

C24H24F3NO2