ChemicalBook > CAS DataBase List > AT-527

AT-527

Product Name: AT-527
CAS No.: 2241337-84-6
Chemical Name: AT-527
Synonyms: AT-527;AT-527(Bemnifosbuvir);Bemnifosbuvir hemisulfate;Bemnifosbuvir hemisulfate (RG-6422;Bemnifosbuvir Hemisulfate (AT-527) ，E1013;Inhibitor,antiviral,phosphoramidate,HCV,nucleotide,SARS-CoV,pangenotypic,Bemnifosbuvir hemisulfate,AT 527,AT527,guanosine,SARS coronavirus,Hepatitis C virus,inhibit;(2S)-isopropyl 2-(((((2R,3R,4R,5R)-5-(2-amino-6-(methylamino)-9H-purin-9-yl)-4-fluoro-3-hydroxy-4-methyltetrahydrofuran-2-yl)methoxy)(phenoxy)phosphoryl)amino)propanoate sulfate;(2S)-Isopropyl 2-(((((2R,3R,4R,5R)-5-(2-amino-6-(methylamino)-9H-purin-9-yl)-4-fluoro-3-hydroxy-4-methyltetrahydrofuran-2-yl)methoxy)(phenoxy)phosphoryl)amino)propanoate hemisulfate
CBNumber: CB68372291
Molecular Formula: C24H35FN7O11PS
Formula Weight: 679.61
MOL File: 2241337-84-6.mol

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AT-527 Property

storage temp.: Store at -20°C
solubility: DMSO : 180 mg/mL (285.45 mM; Need ultrasonic)
form: Solid
color: White to off-white
InChIKey: MKBNJIGFOVMYRL-DBENCIMWNA-N
SMILES: S(O)(O)(=O)=O.C[C@]1([C@@H]([C@@H](COP(=O)(N[C@@H](C)C(=O)OC(C)C)OC2C=CC=CC=2)O[C@H]1N1C=NC2=C(N=C(N)N=C12)NC)O)F |&1:6,7,8,14,30,r|

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

ChemScene

Product number: CS-0143243
Product name: AT-527
Purity: 98.70%
Packaging: 50mg
Price: $1650
Updated: 2021/12/16

DC Chemicals

Product number: 020441
Product name: AT-527
Packaging: 003
Price: $200
Updated: 2021/12/16

DC Chemicals

Product number: 020441
Product name: AT-527
Packaging: 004
Price: $350
Updated: 2021/12/16

DC Chemicals

Product number: 020441
Product name: AT-527
Packaging: 006
Price: $980
Updated: 2021/12/16

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AT-527 Chemical Properties,Usage,Production

Uses

Bemnifosbuvir hemisulfate (AT-527), a hemisulfate salt of AT-511, a guanosine nucleotide proagent, is a potent and orally active HCV viral replication inhibitor. Bemnifosbuvir hemisulfate is highly effective in the control of SARS-CoV-2 (COVID-19) infection in vitro (EC90=0.47 μM). Bemnifosbuvir hemisulfate has pangenotypic antiviral activity[1][2][3].

in vivo

When given orally to rats (500 mg/kg) and monkeys (30 mg/kg, 100 mg/kg or 300 mg/kg), Bemnifosbuvir hemisulfate preferentially delivers high levels of AT-9010 in the liver in vivo^[1].

References

[1] Steven S Good, et al. Preclinical evaluation of AT-527, a novel guanosine nucleotide prodrug with potent, pan-genotypic activity against hepatitis C virus. PLoS One. 2020 Jan 8;15(1):e0227104. DOI:10.1371/journal.pone.0227104
[2] Steven S Good, et al. AT-527, a double prodrug of a guanosine nucleotide analog, is a potent inhibitor of SARS-CoV-2 in vitro and a promising oral antiviral for treatment of COVID-19. Antimicrob Agents Chemother. 2021 Feb 8;AAC.02479-20. DOI:10.1128/AAC.02479-20
[3] Elina Berliba, et al. Safety, pharmacokinetics and antiviral activity of AT-527, a novel purine nucleotide prodrug, in HCV-infected subjects with and without cirrhosis. Antimicrob Agents Chemother. 2019 Sep 30;63(12):e01201-19. DOI:10.1128/AAC.01201-19

AT-527 Preparation Products And Raw materials

Raw materials

Preparation Products

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2241337-84-6, AT-527Related Search:

AT-527

AT-527(Bemnifosbuvir)

Bemnifosbuvir hemisulfate

Bemnifosbuvir hemisulfate (RG-6422

Inhibitor,antiviral,phosphoramidate,HCV,nucleotide,SARS-CoV,pangenotypic,Bemnifosbuvir hemisulfate,AT 527,AT527,guanosine,SARS coronavirus,Hepatitis C virus,inhibit

(2S)-isopropyl 2-(((((2R,3R,4R,5R)-5-(2-amino-6-(methylamino)-9H-purin-9-yl)-4-fluoro-3-hydroxy-4-methyltetrahydrofuran-2-yl)methoxy)(phenoxy)phosphoryl)amino)propanoate sulfate

(2S)-Isopropyl 2-(((((2R,3R,4R,5R)-5-(2-amino-6-(methylamino)-9H-purin-9-yl)-4-fluoro-3-hydroxy-4-methyltetrahydrofuran-2-yl)methoxy)(phenoxy)phosphoryl)amino)propanoate hemisulfate

Bemnifosbuvir Hemisulfate (AT-527) ，E1013

2241337-84-6