Silicate(4-?)?, [2,?5-?dioxo-?1-?pyrrolidinyl 6-?[[[3-?[(29H,?31H-?phthalocyanin-?1-?yl-?κN29,?κN30,?κN31,?κN32)?oxy]?propoxy]?carbonyl]?amino]?hexanoato(2-?)?]?bis[N-?[3-?[(hydroxy-?κO)?dimethylsilyl]?propyl]?-?3-?sulfo-?N,?N-?bis(3-?sulfopropyl)?-?1-?pr
- Product Name
- Silicate(4-?)?, [2,?5-?dioxo-?1-?pyrrolidinyl 6-?[[[3-?[(29H,?31H-?phthalocyanin-?1-?yl-?κN29,?κN30,?κN31,?κN32)?oxy]?propoxy]?carbonyl]?amino]?hexanoato(2-?)?]?bis[N-?[3-?[(hydroxy-?κO)?dimethylsilyl]?propyl]?-?3-?sulfo-?N,?N-?bis(3-?sulfopropyl)?-?1-?pr
- CAS No.
- 916821-46-0
- Chemical Name
- Silicate(4-?)?, [2,?5-?dioxo-?1-?pyrrolidinyl 6-?[[[3-?[(29H,?31H-?phthalocyanin-?1-?yl-?κN29,?κN30,?κN31,?κN32)?oxy]?propoxy]?carbonyl]?amino]?hexanoato(2-?)?]?bis[N-?[3-?[(hydroxy-?κO)?dimethylsilyl]?propyl]?-?3-?sulfo-?N,?N-?bis(3-?sulfopropyl)?-?1-?pr
- Synonyms
- IRDye701Dx;IRDye700DX NHS;IRDye 700DX NHS Ester;photosensitizer DK1232;Near-infrared fluorescent dyes;Silicate(4-?)?, [2,?5-?dioxo-?1-?pyrrolidinyl 6-?[[[3-?[(29H,?31H-?phthalocyanin-?1-?yl-?κN29,?κN30,?κN31,?κN32)?oxy]?propoxy]?carbonyl]?amino]?hexanoato(2-?)?]?bis[N-?[3-?[(hydroxy-?κO)?dimethylsilyl]?propyl]?-?3-?sulfo-?N,?N-?bis(3-?sulfopropyl)?-?1-?pr
- CBNumber
- CB68393764
- Molecular Formula
- C74H96N12NaO27S6Si3(-3)
- Formula Weight
- 1885.25
- MOL File
- 916821-46-0.mol
Silicate(4-?)?, [2,?5-?dioxo-?1-?pyrrolidinyl 6-?[[[3-?[(29H,?31H-?phthalocyanin-?1-?yl-?κN29,?κN30,?κN31,?κN32)?oxy]?propoxy]?carbonyl]?amino]?hexanoato(2-?)?]?bis[N-?[3-?[(hydroxy-?κO)?dimethylsilyl]?propyl]?-?3-?sulfo-?N,?N-?bis(3-?sulfopropyl)?-?1-?pr Property
- form
- Solid
- color
- Blue to blue-green
- InChIKey
- KAVHXPMVVSZIBL-UHFFFAOYSA-J
Silicate(4-?)?, [2,?5-?dioxo-?1-?pyrrolidinyl 6-?[[[3-?[(29H,?31H-?phthalocyanin-?1-?yl-?κN29,?κN30,?κN31,?κN32)?oxy]?propoxy]?carbonyl]?amino]?hexanoato(2-?)?]?bis[N-?[3-?[(hydroxy-?κO)?dimethylsilyl]?propyl]?-?3-?sulfo-?N,?N-?bis(3-?sulfopropyl)?-?1-?pr Chemical Properties,Usage,Production
Uses
IRDye 700DX (IRDye 700DX NHS ester) is a near-infrared (NIR) phthalocyanine dye with extremely high photostability and fluorescence intensity. IRDye 700DX binds to biomolecules. IRDye 700DX has excellent water solubility, large extinction coefficient, high fluorescence quantum yield, and does not aggregate in high ionic strength buffers. IRDye 700DX can be used as a highly flexible photosensitizer[1][2][3].
References
[1] Mitsunaga M, et al. Cancer cell-selective in vivo near infrared photoimmunotherapy targeting specific membrane molecules. Nat Med. 2011 Nov 6;17(12):1685-91. DOI:10.1038/nm.2554
[2] Peng X, et al. Phthalocyanine dye as an extremely photostable and highly fluorescent near-infrared labeling reagent[C]//Optical Molecular Probes for Biomedical Applications. SPIE, 2006, 6097: 113-124.
[3] Tynan CJ, et al. Multicolour single molecule imaging in cells with near infra-red dyes. PLoS One. 2012;7(4):e36265. DOI:10.1371/journal.pone.0036265
Silicate(4-?)?, [2,?5-?dioxo-?1-?pyrrolidinyl 6-?[[[3-?[(29H,?31H-?phthalocyanin-?1-?yl-?κN29,?κN30,?κN31,?κN32)?oxy]?propoxy]?carbonyl]?amino]?hexanoato(2-?)?]?bis[N-?[3-?[(hydroxy-?κO)?dimethylsilyl]?propyl]?-?3-?sulfo-?N,?N-?bis(3-?sulfopropyl)?-?1-?pr Preparation Products And Raw materials
Raw materials
Preparation Products
Silicate(4-?)?, [2,?5-?dioxo-?1-?pyrrolidinyl 6-?[[[3-?[(29H,?31H-?phthalocyanin-?1-?yl-?κN29,?κN30,?κN31,?κN32)?oxy]?propoxy]?carbonyl]?amino]?hexanoato(2-?)?]?bis[N-?[3-?[(hydroxy-?κO)?dimethylsilyl]?propyl]?-?3-?sulfo-?N,?N-?bis(3-?sulfopropyl)?-?1-?pr Suppliers
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