(RS)-4-[5-(4-FLUOROPHENYL)-2-METHYLSULFANYL-3H-IMIDAZOL-4-YL]PYRIDIN-2-YL]-(1-PHENYLETHYL)AMINE]

Product Name: (RS)-4-[5-(4-FLUOROPHENYL)-2-METHYLSULFANYL-3H-IMIDAZOL-4-YL]PYRIDIN-2-YL]-(1-PHENYLETHYL)AMINE]
CAS No.: 549505-65-9
Chemical Name: (RS)-4-[5-(4-FLUOROPHENYL)-2-METHYLSULFANYL-3H-IMIDAZOL-4-YL]PYRIDIN-2-YL]-(1-PHENYLETHYL)AMINE]
Synonyms: ML3403;ML-3043;ML3043; ML 3043;ML 3403, CAS 549505-65-9;P38 MAP KINASE INHIBITOR III;[5-[4-(4-Fluorophenyl)-2-methylthio-1H-imidazol-4-yl]-N-(1-phenylethyl)-2-pyridinamine;4-(4-(4-Fluorophenyl)-2-(methylthio)-1H-imidazol-5-yl)-N-(1-phenylethyl)pyridin-2-amine;2-Pyridinamine, 4-[4-(4-fluorophenyl)-2-(methylthio)-1H-imidazol-5-yl]-N-(1-phenylethyl)-;(RS)-4-[5-(4-FLUOROPHENYL)-2-METHYLSULFANYL-3H-IMIDAZOL-4-YL]PYRIDIN-2-YL]-(1-PHENYLETHYL)AMINE]
CBNumber: CB6842954
Molecular Formula: C23H21FN4S
Formula Weight: 404.5
MOL File: 549505-65-9.mol

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(RS)-4-[5-(4-FLUOROPHENYL)-2-METHYLSULFANYL-3H-IMIDAZOL-4-YL]PYRIDIN-2-YL]-(1-PHENYLETHYL)AMINE] Property

storage temp.: Store at -20°C
solubility: Soluble in DMSO
form: liquid
color: White to off-white

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Safety

WGK Germany: WGK 1
Storage Class: 10 - Combustible liquids

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 506148
Product name: p38 MAP Kinase Inhibitor III
Purity: InSolution, ≥98%
Packaging: 1mg
Price: $222
Updated: 2025/07/31

Tocris

Product number: 4586
Product name: ML3403
Purity: ≥98%(HPLC)
Packaging: 10
Price: $195
Updated: 2021/12/16

Tocris

Product number: 4586
Product name: ML3403
Purity: ≥98%(HPLC)
Packaging: 50
Price: $803
Updated: 2021/12/16

TRC

Product number: M425090
Product name: ML3403
Packaging: 10mg
Price: $145
Updated: 2021/12/16

Usbiological

Product number: 255864
Product name: ML 3403
Packaging: 10mg
Price: $480
Updated: 2021/12/16

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(RS)-4-[5-(4-FLUOROPHENYL)-2-METHYLSULFANYL-3H-IMIDAZOL-4-YL]PYRIDIN-2-YL]-(1-PHENYLETHYL)AMINE] Chemical Properties,Usage,Production

Uses

ML3403 is a potent p38 MAPK inhibitor with an IC50 of 0.38 μM[1].

Biological Activity

Cell permeable: yes', 'Primary Target
p38 MAP kinase', 'Product competes with ATP.', 'Reversible: yes', 'Target IC50: 0.38 μM for p38α; 0.16 and 0.039 μM in suppressing LPS-induced TNF-α and IL-1β release, respectively, in human PBMC; ED50 = 1.33 mg/kg in suppressing LPS-induced TNF-α release in mouse

References

[1] Kammerer B, et al. Pharmacokinetics of ML3403 ({4-[5-(4-fluorophenyl)-2-methylsulfanyl-3H-imidazol-4-yl]-pyridin-2-yl}-(1-phenylethyl)-amine), a 4-Pyridinylimidazole-type p38 mitogen-activated protein kinase inhibitor. Drug Metab Dispos. 2007 Jun;35(6):87 DOI:10.1124/dmd.106.013409

(RS)-4-[5-(4-FLUOROPHENYL)-2-METHYLSULFANYL-3H-IMIDAZOL-4-YL]PYRIDIN-2-YL]-(1-PHENYLETHYL)AMINE] Preparation Products And Raw materials

Raw materials

Preparation Products

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(RS)-4-[5-(4-FLUOROPHENYL)-2-METHYLSULFANYL-3H-IMIDAZOL-4-YL]PYRIDIN-2-YL]-(1-PHENYLETHYL)AMINE] Suppliers

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549505-65-9, (RS)-4-[5-(4-FLUOROPHENYL)-2-METHYLSULFANYL-3H-IMIDAZOL-4-YL]PYRIDIN-2-YL]-(1-PHENYLETHYL)AMINE]Related Search:

ML3403

ML-3043

P38 MAP KINASE INHIBITOR III

(RS)-4-[5-(4-FLUOROPHENYL)-2-METHYLSULFANYL-3H-IMIDAZOL-4-YL]PYRIDIN-2-YL]-(1-PHENYLETHYL)AMINE]

4-(4-(4-Fluorophenyl)-2-(methylthio)-1H-imidazol-5-yl)-N-(1-phenylethyl)pyridin-2-amine

ML3043; ML 3043

[5-[4-(4-Fluorophenyl)-2-methylthio-1H-imidazol-4-yl]-N-(1-phenylethyl)-2-pyridinamine

2-Pyridinamine, 4-[4-(4-fluorophenyl)-2-(methylthio)-1H-imidazol-5-yl]-N-(1-phenylethyl)-

ML 3403, CAS 549505-65-9

549505-65-9

Aromatics

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Intermediates & Fine Chemicals

Pharmaceuticals

Protein Kinase Inhibitors and Activators