ChemicalBook > CAS DataBase List > 1-(6-(trifluoroMethyl)pyridin-3-yl)ethanone

1-(6-(trifluoroMethyl)pyridin-3-yl)ethanone

Product Name
1-(6-(trifluoroMethyl)pyridin-3-yl)ethanone
CAS No.
358780-14-0
Chemical Name
1-(6-(trifluoroMethyl)pyridin-3-yl)ethanone
Synonyms
1-(6-(Trifluoromethyl);1-(6-(Trifluoromethyl)pyridin-3-yl);5-Acetyl-2-(trifluoromethyl)pyridine;5-Acetyl-2-(trifluoromethyl)pyridine 97+%;[6-(TRIFLUOROMETHYL)PYRIDIN-3-YL]ETHANONE;1-[6-(Trifluoromethyl)-3-pyridyl]ethanone;1-[6-(TRIFLUOROMETHYL)PYRIDIN-3-YL]ETHANONE;1-(6-(trifluoroMethyl)pyridine-3-yl)ethanone;1-(6-(trifluoromethyl)pyridin-3-yl) ethenone;1-[6-(Trifluoromethyl)pyridin-3-yl]ethan-1-one
CBNumber
CB6845081
Molecular Formula
C8H6F3NO
Formula Weight
189.13
MOL File
358780-14-0.mol
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1-(6-(trifluoroMethyl)pyridin-3-yl)ethanone Property

Boiling point:
233.7±40.0 °C(Predicted)
Density 
1.280±0.06 g/cm3(Predicted)
storage temp. 
Inert atmosphere,Room Temperature
pka
-1.24±0.22(Predicted)
Appearance
White to light yellow Solid
InChI
InChI=1S/C8H6F3NO/c1-5(13)6-2-3-7(12-4-6)8(9,10)11/h2-4H,1H3
InChIKey
NAUKVLRFGMDIAN-UHFFFAOYSA-N
SMILES
C(=O)(C1=CC=C(C(F)(F)F)N=C1)C
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Safety

HS Code 
2933399990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P330Rinse mouth.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TRC
Product number
T899335
Product name
1-(6-(trifluoromethyl)pyridin-3-yl)ethanone
Packaging
500mg
Price
$310
Updated
2021/12/16
Apolloscientific
Product number
PC5837
Product name
5-Acetyl-2-(trifluoromethyl)pyridine
Purity
97+%
Packaging
5g
Price
$439
Updated
2021/12/16
Apolloscientific
Product number
PC5837
Product name
5-Acetyl-2-(trifluoromethyl)pyridine
Purity
97+%
Packaging
250mg
Price
$59
Updated
2021/12/16
SynQuest Laboratories
Product number
4H17-3-Y4
Product name
5-Acetyl-2-(trifluoromethyl)pyridine
Purity
97.0%
Packaging
250mg
Price
$95
Updated
2021/12/16
SynQuest Laboratories
Product number
4H17-3-Y4
Product name
5-Acetyl-2-(trifluoromethyl)pyridine
Purity
97.0%
Packaging
1g
Price
$236
Updated
2021/12/16
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1-(6-(trifluoroMethyl)pyridin-3-yl)ethanone Chemical Properties,Usage,Production

Uses

1-(6-(Trifluoromethyl)pyridin-3-yl)ethanone can be used as novel GPR119 agonists.

Synthesis

To a solution of 2-trifluoromethyl-5-bromopyridine (5.0 g, 22 mmol) in Et2O (50 mL) was added sec-BuLi (0.91 M in cyclohexane, 24 mL, 22 mmol) at -78 °C. After 10 minutes of stirring, N,N-dimethylaminoacetamide (2.3 mL, 24 mmol) dissolved in Et2O (10 mL) was added drop wise. Stirring was continued at -78 °C for 1 h and then at rt over night. The reaction mixture was poured into water (100 mL) and the water phase was extracted with Et2O (3×100 mL). Combined organics were washed with water and brine and dried (MgSO4). After careful evaporation of the solvent, the crude was purified by column chromotography (SiO2, pentane/ether 9/1) to give 1-(6-(Trifluoromethyl)pyridin-3-yl)ethanone (2.3 g, 12 mmol, 54%) as a light yellow solid. 1H NMR (CDCl3) δ 9.26 (br s, 1H) 8.43 (br d, J=5.6 Hz, 1H) 7.83 (br d, J=7.2 Hz, 1H) 2.71 (s, 3H).

References

[1] Patent: US2008/275037, 2008, A1. Location in patent: Page/Page column 25
[2] Patent: WO2008/123963, 2008, A1. Location in patent: Page/Page column 48-49
[3] Patent: US2012/302608, 2012, A1. Location in patent: Page/Page column 12

1-(6-(trifluoroMethyl)pyridin-3-yl)ethanone Preparation Products And Raw materials

Raw materials

Preparation Products

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1-(6-(trifluoroMethyl)pyridin-3-yl)ethanone Suppliers

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View Lastest Price from 1-(6-(trifluoroMethyl)pyridin-3-yl)ethanone manufacturers

Henan Aochuang Chemical Co.,Ltd.
Product
1-[6-(TRIFLUOROMETHYL)PYRIDIN-3-YL]ETHANONE 358780-14-0
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
98%
Supply Ability
1ton
Release date
2022-09-19
Zhengzhou Anbu Chem Co.,Ltd
Product
1-[6-(TRIFLUOROMETHYL)PYRIDIN-3-YL]ETHANONE 358780-14-0
Price
US $0.00/KG
Min. Order
0.1KG
Purity
98%
Supply Ability
1000KGS
Release date
2023-04-14
Zhengzhou Anbu Chem Co.,Ltd
Product
1-[6-(TRIFLUOROMETHYL)PYRIDIN-3-YL]ETHANONE 358780-14-0
Price
US $0.00/KG
Min. Order
0.1KG
Purity
99%
Supply Ability
1000KGS
Release date
2023-06-13

358780-14-0, 1-(6-(trifluoroMethyl)pyridin-3-yl)ethanoneRelated Search:

N-BENZYL-5-OXO-2-(TRIFLUOROMETHYL)-5H-CHROMENO[2,3-B]PYRIDINE-3-CARBOXAMIDE N-METHOXY-N-METHYL-N'-[5-OXO-2-(TRIFLUOROMETHYL)-5H-CHROMENO[2,3-B]PYRIDIN-3-YL]UREA N-(2,6-DIMETHYLPHENYL)-5-OXO-2-(TRIFLUOROMETHYL)-5H-CHROMENO[2,3-B]PYRIDINE-3-CARBOXAMIDE N-(2,4-DIFLUOROPHENYL)-5-OXO-2-(TRIFLUOROMETHYL)-5H-CHROMENO[2,3-B]PYRIDINE-3-CARBOXAMIDE 5-OXO-2-(TRIFLUOROMETHYL)-N-[3-(TRIFLUOROMETHYL)BENZYL]-5H-CHROMENO[2,3-B]PYRIDINE-3-CARBOXAMIDE S-ETHYL N-[5-OXO-2-(TRIFLUOROMETHYL)-5H-CHROMENO[2,3-B]PYRIDIN-3-YL]CARBAMOTHIOATE 5-OXO-N-(3-PYRIDINYLMETHYL)-2-(TRIFLUOROMETHYL)-5H-CHROMENO[2,3-B]PYRIDINE-3-CARBOXAMIDE METHYL N-[5-OXO-2-(TRIFLUOROMETHYL)-5H-CHROMENO[2,3-B]PYRIDIN-3-YL]CARBAMATE N,N-DIMETHYL-N'-[5-OXO-2-(TRIFLUOROMETHYL)-5H-CHROMENO[2,3-B]PYRIDIN-3-YL]UREA N-(4-CHLOROBENZYL)-5-OXO-2-(TRIFLUOROMETHYL)-5H-CHROMENO[2,3-B]PYRIDINE-3-CARBOXAMIDE N-METHYL-5-OXO-2-(TRIFLUOROMETHYL)-5H-CHROMENO[2,3-B]PYRIDINE-3-CARBOXAMIDE N-ISOPROPYL-5-OXO-2-(TRIFLUOROMETHYL)-5H-CHROMENO[2,3-B]PYRIDINE-3-CARBOXAMIDE 5-OXO-2-(TRIFLUOROMETHYL)-N-[3-(TRIFLUOROMETHYL)PHENYL]-5H-CHROMENO[2,3-B]PYRIDINE-3-CARBOXAMIDE 5-OXO-2-(TRIFLUOROMETHYL)-5H-CHROMENO[2,3-B]PYRIDINE-3-CARBOXYLIC ACID N-ALLYL-5-OXO-2-(TRIFLUOROMETHYL)-5H-CHROMENO[2,3-B]PYRIDINE-3-CARBOXAMIDE N-(4-CHLOROPHENYL)-5-OXO-2-(TRIFLUOROMETHYL)-5H-CHROMENO[2,3-B]PYRIDINE-3-CARBOXAMIDE 5-OXO-N-PHENYL-2-(TRIFLUOROMETHYL)-5H-CHROMENO[2,3-B]PYRIDINE-3-CARBOXAMIDE 5-OXO-N-(2-PYRIDINYLMETHYL)-2-(TRIFLUOROMETHYL)-5H-CHROMENO[2,3-B]PYRIDINE-3-CARBOXAMIDE

  • 5-Acetyl-2-(trifluoromethyl)pyridine
  • 1-(6-(trifluoroMethyl)pyridine-3-yl)ethanone
  • [6-(TRIFLUOROMETHYL)PYRIDIN-3-YL]ETHANONE
  • 1-(6-(Trifluoromethyl)
  • 1-(6-(Trifluoromethyl)pyridin-3-yl)
  • 1-[6-(TRIFLUOROMETHYL)PYRIDIN-3-YL]ETHANONE
  • ETHANONE, 1-[6-(TRIFLUOROMETHYL)-3-PYRIDINYL]-
  • 1-[6-(Trifluoromethyl)pyridin-3-yl]ethan-1-one
  • 5-Acetyl-2-(trifluoromethyl)pyridine 97+%
  • 1-（6-(trifluoromethyl) -3-pyridine ） ethyl ketone
  • 1-(6-(trifluoromethyl)pyridin-3-yl) ethenone
  • 1-[6-(Trifluoromethyl)-3-pyridyl]ethanone
  • 358780-14-0