1-(6-(trifluoroMethyl)pyridin-3-yl)ethanone
- Product Name
- 1-(6-(trifluoroMethyl)pyridin-3-yl)ethanone
- CAS No.
- 358780-14-0
- Chemical Name
- 1-(6-(trifluoroMethyl)pyridin-3-yl)ethanone
- Synonyms
- 1-(6-(Trifluoromethyl);1-(6-(Trifluoromethyl)pyridin-3-yl);5-Acetyl-2-(trifluoromethyl)pyridine;5-Acetyl-2-(trifluoromethyl)pyridine 97+%;[6-(TRIFLUOROMETHYL)PYRIDIN-3-YL]ETHANONE;1-[6-(Trifluoromethyl)-3-pyridyl]ethanone;1-[6-(TRIFLUOROMETHYL)PYRIDIN-3-YL]ETHANONE;1-(6-(trifluoroMethyl)pyridine-3-yl)ethanone;1-(6-(trifluoromethyl)pyridin-3-yl) ethenone;1-[6-(Trifluoromethyl)pyridin-3-yl]ethan-1-one
- CBNumber
- CB6845081
- Molecular Formula
- C8H6F3NO
- Formula Weight
- 189.13
- MOL File
- 358780-14-0.mol
1-(6-(trifluoroMethyl)pyridin-3-yl)ethanone Property
- Boiling point:
- 233.7±40.0 °C(Predicted)
- Density
- 1.280±0.06 g/cm3(Predicted)
- storage temp.
- Inert atmosphere,Room Temperature
- pka
- -1.24±0.22(Predicted)
- InChI
- InChI=1S/C8H6F3NO/c1-5(13)6-2-3-7(12-4-6)8(9,10)11/h2-4H,1H3
- InChIKey
- NAUKVLRFGMDIAN-UHFFFAOYSA-N
- SMILES
- C(=O)(C1=CC=C(C(F)(F)F)N=C1)C
Safety
- HS Code
- 2933399990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P321Specific treatment (see … on this label).
P330Rinse mouth.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- T899335
- Product name
- 1-(6-(trifluoromethyl)pyridin-3-yl)ethanone
- Packaging
- 500mg
- Price
- $310
- Updated
- 2021/12/16
- Product number
- PC5837
- Product name
- 5-Acetyl-2-(trifluoromethyl)pyridine
- Purity
- 97+%
- Packaging
- 5g
- Price
- $439
- Updated
- 2021/12/16
- Product number
- PC5837
- Product name
- 5-Acetyl-2-(trifluoromethyl)pyridine
- Purity
- 97+%
- Packaging
- 250mg
- Price
- $59
- Updated
- 2021/12/16
- Product number
- 4H17-3-Y4
- Product name
- 5-Acetyl-2-(trifluoromethyl)pyridine
- Purity
- 97.0%
- Packaging
- 250mg
- Price
- $95
- Updated
- 2021/12/16
- Product number
- 4H17-3-Y4
- Product name
- 5-Acetyl-2-(trifluoromethyl)pyridine
- Purity
- 97.0%
- Packaging
- 1g
- Price
- $236
- Updated
- 2021/12/16
1-(6-(trifluoroMethyl)pyridin-3-yl)ethanone Chemical Properties,Usage,Production
Uses
1-(6-(Trifluoromethyl)pyridin-3-yl)ethanone can be used as novel GPR119 agonists.
Synthesis
To a solution of 2-trifluoromethyl-5-bromopyridine (5.0 g, 22 mmol) in Et2O (50 mL) was added sec-BuLi (0.91 M in cyclohexane, 24 mL, 22 mmol) at -78 °C. After 10 minutes of stirring, N,N-dimethylaminoacetamide (2.3 mL, 24 mmol) dissolved in Et2O (10 mL) was added drop wise. Stirring was continued at -78 °C for 1 h and then at rt over night. The reaction mixture was poured into water (100 mL) and the water phase was extracted with Et2O (3×100 mL). Combined organics were washed with water and brine and dried (MgSO4). After careful evaporation of the solvent, the crude was purified by column chromotography (SiO2, pentane/ether 9/1) to give 1-(6-(Trifluoromethyl)pyridin-3-yl)ethanone (2.3 g, 12 mmol, 54%) as a light yellow solid. 1H NMR (CDCl3) δ 9.26 (br s, 1H) 8.43 (br d, J=5.6 Hz, 1H) 7.83 (br d, J=7.2 Hz, 1H) 2.71 (s, 3H).
1-(6-(trifluoroMethyl)pyridin-3-yl)ethanone Preparation Products And Raw materials
Raw materials
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View Lastest Price from 1-(6-(trifluoroMethyl)pyridin-3-yl)ethanone manufacturers
- Product
- 1-(6-(trifluoroMethyl)pyridin-3-yl)ethanone 358780-14-0
- Price
- US $20.00-0.60/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- g-kg-tons, free sample is available
- Release date
- 2024-04-03
- Product
- 1-[6-(TRIFLUOROMETHYL)PYRIDIN-3-YL]ETHANONE 358780-14-0
- Price
- US $0.00/KG
- Min. Order
- 0.1KG
- Purity
- 99%
- Supply Ability
- 1000KGS
- Release date
- 2023-06-13
- Product
- 1-[6-(TRIFLUOROMETHYL)PYRIDIN-3-YL]ETHANONE 358780-14-0
- Price
- US $0.00/KG
- Min. Order
- 0.1KG
- Purity
- 98%
- Supply Ability
- 1000KGS
- Release date
- 2023-04-14