bialamicol Property

Boiling point:

506.6±45.0 °C(Predicted)

Density 

1.040±0.06 g/cm3(Predicted)

pka

9.67±0.50(Predicted)

Hazard and Precautionary Statements (GHS)

bialamicol Chemical Properties,Usage,Production

Originator

Camoform HCl,Parke Davis,US,1956

Uses

Anti-amebic.

Definition

ChEBI: Bialamicol is a member of hydroxybiphenyls.

Manufacturing Process

Paraformaldehyde (7.59) (0.25mol) and 18.3 g (0.25 mol) of diethylamine are mixed in 25 cc of alcohol and warmed until a clear solution is obtained. The solution is cooled and mixed with 26.6 g (0.10 mol) of 3,3'-diallyl-4,4'- biphenol in 25 cc of alcohol. After standing several hours, the solution is warmed for one hour on the steam bath, allowing the alcohol to boil off. The residue is then taken up in ether and water, the ether layer separated and washed with 2% sodium hydroxide solution and finally with water. The washed ether solution is dried over solid potassium carbonate, and filtered. After acidifying with alcoholic hydrogen chloride, the ether is distilled off and the alcoholic residue diluted with an equal volume of acetone. The crystalline hydrochloride is filtered off, triturated with alcohol, diluted with several volumes of acetone, filtered and dried; MP 209°-210°C.

brand name

Camoform Hydrochloride (Parke-Davis).

Therapeutic Function

Antiamebic