Beclobrate
- Product Name
- Beclobrate
- CAS No.
- 55937-99-0
- Chemical Name
- Beclobrate
- Synonyms
- Turec;Beclipur;Sgd-24774;Beclobrate;Beclobrate USP/EP/BP;Ethyl 2-(4-(4-chlorobenzyl)phenoxy)-2-Methylbutanoate;Ethyl(±)-2-[[α(-(4-chlorophenyl)-4-tolyl]oxy]-2-methylbutyrate;2-[4-(4-Chlorobenzyl)phenoxy]-2-methylbutyric acid ethyl ester;Butanoic acid, 2-[4-[(4-chlorophenyl)Methyl]phenoxy]-2-Methyl-, ethyl ester
- CBNumber
- CB6875424
- Molecular Formula
- C20H23ClO3
- Formula Weight
- 346.85
- MOL File
- 55937-99-0.mol
Beclobrate Property
- Boiling point:
- bp0.01-0.1 200-204°
- storage temp.
- 2-8°C
Safety
- Toxicity
- LD50 orally in mice: 8000 mg/kg (Thiele, 1979)
N-Bromosuccinimide Price
- Product number
- API0001599
- Product name
- BECLOBRATE
- Purity
- 95.00%
- Packaging
- 100MG
- Price
- $1030.84
- Updated
- 2021/12/16
- Product number
- API0001599
- Product name
- BECLOBRATE
- Purity
- 95.00%
- Packaging
- 1G
- Price
- $1904.7
- Updated
- 2021/12/16
- Product number
- CD31001475
- Product name
- Beclobrate
- Purity
- 95+%
- Packaging
- 1g
- Price
- $947
- Updated
- 2021/12/16
Beclobrate Chemical Properties,Usage,Production
Description
Beclobrate is a hypolipidemic agent related structurally to clofibrate. It is reportedly useful in types IIa-V hyperlipoproteinemias, promoting normalization of t h e atherogenic index.
Originator
Siegfried AG (Switzerland)
Definition
ChEBI: Beclobrate is a diarylmethane.
Manufacturing Process
87.0 g (0.4 mol) of 4-chloro-4'-hydroxydiphenylmethane are heated together with 27.0 g (0.2 mol) of anhydrous potassium carbonate in 350 ml of anhydrous xylene for 30 min to reflux temperature, whereafter a solution of 83.5 g (0.4 mol) of 2-bromo-2-ethyl-2-methyl acetic acid ethyl ester in 50 ml of anhydrous xylene is added. The mixture is kept for 24 hours and with vigorous stirring at reflux temperature. After filtering off the precipitated potassium bromide and evaporating the solvent in a Buchi rotary evaporator, the residue is taken up in ether and extracted with normal sodium hydroxide solution. The ether extracts are washed with water, dried over MgSO4 and concentrated by evaporation. The brown oil (82.0 g) thereby obtained is dissolved in n-hexane and filtered through a column of 200 g of basic Al2O3. After evaporating the solvent and distillation at reduced pressure, 34.7 g of pure ethyl (+/-)-2-((α-(p-chlorophenyl)-p-tolyl)oxy)-2-methylbutyrate are obtained with the boiling point 200-204°C/0.01-0.1 mm Hg.
brand name
BECLOSCLERIN
Therapeutic Function
Antihyperlipidemic
World Health Organization (WHO)
Beclobrate, an antihyperlipidaemic agent, was introduced into medicine in 1985. Although a causal relationship between the use of the drug and hepatic toxicity has not been established, the Intercantonal Office for the Control of Medicines has withdrawn marketing authorization since safer therapeutic alternatives are available. Beclobrate is not registered elsewhere.
Beclobrate Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Beclobrate manufacturers
- Product
- Beclobrate 55937-99-0
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 99.0%
- Supply Ability
- 500 MT
- Release date
- 2020-05-11