2,3-dichloro-6-nitroaniline
- Product Name
- 2,3-dichloro-6-nitroaniline
- CAS No.
- 65078-77-5
- Chemical Name
- 2,3-dichloro-6-nitroaniline
- Synonyms
- 2,3-Dichloro-6-nitrobenzenamine;Benzenamine,2,3-dichloro-6-nitro-
- CBNumber
- CB6876719
- Molecular Formula
- C6H4Cl2N2O2
- Formula Weight
- 207.01
- MOL File
- 65078-77-5.mol
2,3-dichloro-6-nitroaniline Property
- Melting point:
- 166.7 °C
- Boiling point:
- 323.5±37.0 °C(Predicted)
- Density
- 1.624±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C(protect from light)
- solubility
- DMSO (Slightly), Methanol (Slightly)
- form
- Solid
- pka
- -3.55±0.25(Predicted)
- color
- Light Yellow to Yellow
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- D436775
- Product name
- 2,3-Dichloro-6-nitroaniline
- Packaging
- 50mg
- Price
- $80
- Updated
- 2021/12/16
- Product number
- D436775
- Product name
- 2,3-Dichloro-6-nitroaniline
- Packaging
- 250mg
- Price
- $110
- Updated
- 2021/12/16
- Product number
- D436775
- Product name
- 2,3-Dichloro-6-nitroaniline
- Packaging
- 1g
- Price
- $275
- Updated
- 2021/12/16
- Product number
- D436775
- Product name
- 2,3-Dichloro-6-nitroaniline
- Packaging
- 2.5g
- Price
- $525
- Updated
- 2021/12/16
- Product number
- CS-0060318
- Product name
- 2,3-Dichloro-6-nitroaniline
- Packaging
- 5g
- Price
- $356
- Updated
- 2021/12/16
2,3-dichloro-6-nitroaniline Chemical Properties,Usage,Production
Uses
2,3-Dichloro-6-nitroaniline is used as a reagent in the synthesis of 3-alkyl-, 3-halomethyl- and 3-carboxyethylquinoxaline-2-ones which have potential antimicrobial activity.
Synthesis
17700-09-3
65078-77-5
General procedure for the synthesis of 2,3-dichloro-6-nitroaniline from 2,3,4-trichloronitrobenzene: 4000 g of chlorobenzene, 10121 g of ammonia (40% by mass) and 2,3,4-trichloronitrobenzene (1:3 by weight with ammonia) prepared in step S1 were pumped into an autoclave. The reaction temperature was raised to 145 °C under stirring conditions and the reaction was held at this temperature for 5 hours. Upon completion of the reaction, the reaction mixture was cooled to room temperature with cooling water. Subsequently, the material was separated by hydraulic filtration until layered. After distillation to recover the chlorobenzene layer, calcium oxide was added to the ammonia layer to convert ammonium ions to free ammonia. Next, the mixture was heated and evaporated and the free ammonia in the vapor was absorbed by water and recycled for the preparation of 2,3-dichloro-6-nitroaniline. The filter cake was washed to neutrality with hot water at a temperature of 40-60 °C and dried to give the target product 2,3-dichloro-6-nitroaniline. The product was analyzed by liquid chromatography with 97.9% purity and 99.2% yield.
References
[1] Patent: CN106854162, 2017, A. Location in patent: Paragraph 0033; 0034; 0036; 0037-0039; 0041-0044; 0046; 0047
[2] Patent: WO2016/40764, 2016, A1. Location in patent: Page/Page column 50; 51
[3] Journal of Medicinal Chemistry, 1996, vol. 39, # 4, p. 881 - 891
[4] Justus Liebigs Annalen der Chemie, 1879, vol. 196, p. 222
[5] Zhurnal Russkago Fiziko-Khimicheskago Obshchestva, 1879, vol. 11, p. 332
2,3-dichloro-6-nitroaniline Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 2,3-dichloro-6-nitroaniline manufacturers
- Product
- 2,3-dichloro-6-nitroaniline 65078-77-5
- Price
- US $2.00/KG
- Min. Order
- 1g
- Purity
- 98%MIN
- Supply Ability
- ASK
- Release date
- 2020-01-07