bupicomide
- Product Name
- bupicomide
- CAS No.
- 22632-06-0
- Chemical Name
- bupicomide
- Synonyms
- Sch-10595;bupicomide;Fusaramide;5-Butylpyridine-2-carboxamide;5-Butyl-2-pyridinecarboxamide;2-Pyridinecarboxamide, 5-butyl-;5-butyl-pyridine-2-carboxylic acid amide
- CBNumber
- CB6878197
- Molecular Formula
- C10H14N2O
- Formula Weight
- 178.234
- MOL File
- 22632-06-0.mol
bupicomide Property
- Melting point:
- 128 °C
- Boiling point:
- 338.6±30.0 °C(Predicted)
- Density
- 1.066±0.06 g/cm3(Predicted)
- pka
- 15.28±0.50(Predicted)
N-Bromosuccinimide Price
- Product number
- B490838
- Product name
- 5-butylpyridine-2-carboxamide
- Packaging
- 10mg
- Price
- $65
- Updated
- 2021/12/16
- Product number
- B490838
- Product name
- 5-butylpyridine-2-carboxamide
- Packaging
- 50mg
- Price
- $240
- Updated
- 2021/12/16
- Product number
- B490838
- Product name
- 5-butylpyridine-2-carboxamide
- Packaging
- 100mg
- Price
- $350
- Updated
- 2021/12/16
- Product number
- CHM0996980
- Product name
- 5-BUTYL-2-PYRIDINECARBOXAMIDE
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $501.28
- Updated
- 2021/12/16
- Product number
- D6782
- Product name
- 5-butyl-2-Pyridinecarboxamide
- Purity
- 97.00%
- Packaging
- 25G
- Price
- $13300
- Updated
- 2021/12/16
bupicomide Chemical Properties,Usage,Production
Originator
Bupicomide,ZYF Pharm Chemical
Uses
Antihypertensive.
Definition
ChEBI: Bupicomide is an organothiophosphorus compound and a phosphoramide.
Manufacturing Process
3-n-Butyl-6-methyl-3,4-dihydro-1,2-pyran was obtained and isolated from the
reaction mixture by fractional distillation in vacuum to separate a by-product
formed by cyclodimerisation of methyl vinylketone. The yield of the3-n-butyl-
6-methyl-3,4-dihydro-1,2-pyran was 47% (boiling point 106-107°C.
The saponification of the 3-n-butyl-6-methyl-3,4-dihydro-1,2-pyran was
accomplished by heating for 0.5 h in a mixture with acetic acid. The 1-methyl-
4-n-butyl-1,5-dicarbonyl acid formed not isolated from the reaction mixture
was added to hydroxylamine. The reaction with hydroxylamine was carried out
by gradual addition of acetic acid solution of 1,5-dicarbonyl compound to the
stirring refluxing suspension of hydroxylamine in glacial acetic acid. By usual
treatment was fractionned in vacuum to yield 37.5% of 2-methyl-5-nbutylpyridine,
boiling point 105°C.
The 2-methyl-5-n-butylpyridine was oxidated by selenium dioxide in pyridine
to 5-n-butyl-2-pyridine carboxylic (fusarinic) acid, melting point 100-101°C.
25.0 g of the 5-n-butyl-2-pyridine carboxylic (fusarinic) acid and 25 ml of
thionyl chloride were mixed; after all of the acid is dissolved, concentrate (in
vacuo) the mixture and take up the mixture in 500 ml of anhydrous benzene;
with cooling add the mixture to a solution of excess ammonia in 1 l of
benzene, concentrate (in vacuo) the resulting mixture; add water and
potassium carbonate and extract the amide with ether; dry and concentrate
the ether extract and 5-n-butyl-2-pyridine carboxamide was obtained
(recrystallize from acetonitrile).
Therapeutic Function
Antihypertensive
bupicomide Preparation Products And Raw materials
Raw materials
Preparation Products
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