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pirozadil

Product Name
pirozadil
CAS No.
54110-25-7
Chemical Name
pirozadil
Synonyms
pirozadil;inhibit,Pirozadil,Inhibitor;Pyridine-2,6-diylbis(methylene) bis(3,4,5-trimethoxybenzoate);Bis(3,4,5-trimethoxybenzoic acid)2,6-pyridinediylbismethylene ester;Benzoic acid, 3,4,5-trimethoxy-, 1,1'-[2,6-pyridinediylbis(methylene)] ester
CBNumber
CB6894155
Molecular Formula
C27H29NO10
Formula Weight
527.52
MOL File
54110-25-7.mol
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pirozadil Property

Melting point:
119-126°
storage temp. 
Store at -20°C
solubility 
DMSO : 62.5 mg/mL (118.48 mM);Water : < 0.1 mg/mL (insoluble)
form 
Solid
color 
Light yellow to yellow
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

TRC
Product number
P510500
Product name
Pirozadil
Packaging
2.5g
Price
$1320
Updated
2021/12/16
Medical Isotopes, Inc.
Product number
61327
Product name
Pirozadil
Packaging
2.5g
Price
$2200
Updated
2021/12/16
Acrotein
Product number
UT01109
Product name
Pyridine-2,6-diylbis(methylene)bis(3,4,5-trimethoxybenzoate)
Purity
97%
Packaging
0.25g
Price
$333.33
Updated
2021/12/16
DC Chemicals
Product number
DC26158
Product name
Pirozadil
Purity
>98%
Packaging
250mg
Price
$1100
Updated
2021/12/16
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pirozadil Chemical Properties,Usage,Production

Originator

Pemix ,Prodes ,Spain,1982

Uses

Pirozadil is a novel hypolipidemic agent on cerebral blood flow and has shown to significantly diminish vascular cerebral resistance to a much greater degree than nicotinic acid (N429250) and pyridinol carbamate.

Definition

ChEBI: Pirozadil is a trihydroxybenzoic acid.

Manufacturing Process

15 kg (70.7 mols) of 3,4,5-trimethoxybenzoic acid and 65 liters of benzene were introduced into a reactor, to which mixture was added 27.4 liters of thionyl chloride. The mass was heated to 56°C to 70°C during a period of 5 hours. The excess of benzene and thionyl chloride was distilled under vacuum. The residue was kept under vacuum at 120°C to 123°C for 1 hour, to obtain a hard crystalline solid.
A solution comprising 3.24 kg (23.3 mols) of pyridine-2,6-dimethanol in 35 liters of pure pyridine was added to the residue and the mass was heated to 80°C for 2? hours. The reaction mass became brown in color. The chlorhydrate of pyridine so formed was cooled and crystallized. The resulting reaction mass was then poured into water. The precipitate obtained was filtered, repeatedly rinsed with water, and dissolved in 400 liters of methanol. The resulting solution was filtered with activated charcoal. From this filtration 50 liters of methanol were distilled at normal pressure and then crystallized. 8.35 kg (15.8 mols) of pyridine-2,6dimethanol trimethoxybenzoate were obtained, which represented a yield of 68%.
The product was a white crystalline solid which melted at 119°C to 126°C. Recrystallization in methanolone gave a product which melted at 126°C to 127°C.

Therapeutic Function

Antihyperlipidemic, Platelet aggregation inhibitor

pirozadil Preparation Products And Raw materials

Raw materials

Preparation Products

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pirozadil Suppliers

J & K SCIENTIFIC LTD.
Tel
010-82848833 400-666-7788
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
96815
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76
Shanghai T&W Pharmaceutical Co., Ltd.
Tel
+86 21 61551611
Fax
+86 21 50676805
Country
China
ProdList
9891
Advantage
58
Shanghai Lollane Biological Technology Co.,Ltd.
Tel
021-52996696,15000506266 15000506266
Fax
+86-21-52996696
Country
China
ProdList
4512
Advantage
55
ShangHai Biochempartner Co.,Ltd
Tel
177-54423994 17754423994
Fax
QQ:2853530913
Email
2853530910@QQ.com
Country
China
ProdList
8011
Advantage
62
Shanghai SuperLan Chemcial Technique Centre
Tel
021-2022843681 15618226720
Fax
+86-21-51601218
Email
lucy@atkchemical.com
Country
China
ProdList
9204
Advantage
58
Shenzhen Regent Biochemical Technology Co., Ltd.
Tel
0755-0755-85201366 18938635012
Fax
0755-85201366
Email
sales@regentsciences.com
Country
China
ProdList
9355
Advantage
58
Shenzhen Polymeri Biochemical Technology Co., Ltd.
Tel
+86-400-002-6226 +86-13028896684;
Email
sales@rrkchem.com
Country
China
ProdList
57412
Advantage
58
TargetMol Chemicals Inc.
Tel
+1-781-999-5354 +1-00000000000
Email
marketing@targetmol.com
Country
United States
ProdList
32165
Advantage
58
InvivoChem
Tel
+1-708-310-1919 +1-13798911105
Fax
708-557-7486
Email
sales@invivochem.cn
Country
United States
ProdList
6391
Advantage
58
Career Henan Chemica Co
Tel
+86-0371-86658258 +8613203830695
Fax
0371-86658258
Email
laboratory@coreychem.com
Country
China
ProdList
30240
Advantage
58

54110-25-7, pirozadilRelated Search:


  • pirozadil
  • Bis(3,4,5-trimethoxybenzoic acid)2,6-pyridinediylbismethylene ester
  • Benzoic acid, 3,4,5-trimethoxy-, 1,1'-[2,6-pyridinediylbis(methylene)] ester
  • inhibit,Pirozadil,Inhibitor
  • Pyridine-2,6-diylbis(methylene) bis(3,4,5-trimethoxybenzoate)
  • 54110-25-7
  • C27H29NO10