AP1189 acetate

Product Name: AP1189 acetate
CAS No.: 959850-74-9
Chemical Name: AP1189 acetate
Synonyms: AP1189;AP1189 acetate;AP1189 acetate, 10 mM in DMSO;AP1189 acetate,AP-1189 acetate;Resomelagon acetate (AP1189 acetate);(E)-N-[Trans-3-{1-(2-nitrophenyl)-1H-pyrrol-2-yl} allylidenamino]guanidinium acetate;2-[3-[1-(2-Nitrophenyl)-1H-pyrrol-2-yl]-2-propen-1-ylidene]hydrazinecarboximidamide acetate
CBNumber: CB69017524
Molecular Formula: C16H18N6O4
Formula Weight: 358.36
MOL File: 959850-74-9.mol

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AP1189 acetate Property

solubility: DMF: 10 mg/ml
DMSO: 10 mg/ml
Ethanol: 0.2 mg/ml

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Hazard and Precautionary Statements (GHS)

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AP1189 acetate Chemical Properties,Usage,Production

Description

AP1189 is a biased agonist at receptors MC1 and MC3. AP1189 reduced cytokine release, an effect reliant on both MC1 and MC3 as evident from the use of Mc1r(-/-) and Mc3r(-/-) macrophages. No melanogenesis was induced by AP1189 in B16-F10 melanocytes. In vivo, oral AP1189 elicited anti-inflammatory actions in peritonitis and, upon administration at the peak of inflammation, accelerated the resolution phase by ～3-fold.

Uses

(E/Z)-Resomelagon acetate is an agonist of melanocortin receptor 1 (MC1R) and MC3R with anti-inflammatory activities. (E/Z)-Resomelagon can be utilized in inflammation research[1].

IC 50

MC1R; MC3R

References

[1] Montero-Melendez T, et al. Biased agonism as a novel strategy to harness the proresolving properties of melanocortin receptors without eliciting melanogenic effects. J Immunol. 2015 Apr 1;194(7):3381-8. DOI:10.4049/jimmunol.1402645

AP1189 acetate Preparation Products And Raw materials

Raw materials

Preparation Products

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AP1189 acetate Suppliers

China 27 United States 3 Global 30

WUHAN SUN-SHINE BIO-TECHNOLOGY Co., Ltd.

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959850-74-9, AP1189 acetateRelated Search:

AP1189 acetate

AP1189

AP1189 acetate,AP-1189 acetate

AP1189 acetate, 10 mM in DMSO

2-[3-[1-(2-Nitrophenyl)-1H-pyrrol-2-yl]-2-propen-1-ylidene]hydrazinecarboximidamide acetate

Resomelagon acetate (AP1189 acetate)

(E)-N-[Trans-3-{1-(2-nitrophenyl)-1H-pyrrol-2-yl} allylidenamino]guanidinium acetate

959850-74-9