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tioclomarol

Product Name
tioclomarol
CAS No.
22619-35-8
Chemical Name
tioclomarol
Synonyms
ApegMone;tioclomarol;3-[5-Chloro-α-(p-chloro-β-hydroxyphenethyl)-2-thenyl]-4-hydroxy-couMarin;3-[1-(5-Chloro-2-thienyl)-3-hydroxy-3-(4-chlorophenyl)propyl]-4-hydroxycoumarin;3-[3-(4-Chlorophenyl)-1-(5-chloro-2-thienyl)-3-hydroxypropyl]-4-hydroxy-2H-1-benzopyran-2-one;2H-1-Benzopyran-2-one, 3-[3-(4-chlorophenyl)-1-(5-chloro-2-thienyl)-3-hydroxypropyl]-4-hydroxy-
CBNumber
CB6905482
Molecular Formula
C22H16Cl2O4S
Formula Weight
447.33
MOL File
22619-35-8.mol
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tioclomarol Property

Melting point:
104°
Boiling point:
660.0±55.0 °C(Predicted)
Density 
1.519±0.06 g/cm3(Predicted)
storage temp. 
-20°C Freezer
solubility 
Chloroform (Slightly), Methanol (Slightly)
form 
Solid
pka
4.50±1.00(Predicted)
color 
White
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

TRC
Product number
T444650
Product name
Tioclomarol
Packaging
10mg
Price
$185
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
API0012652
Product name
TIOCLOMAROL
Purity
95.00%
Packaging
10MG
Price
$750.75
Updated
2021/12/16
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tioclomarol Chemical Properties,Usage,Production

Originator

Apegmone,Oberval,France,1978

Uses

A coumarin (C755380) derivative classified as an anticoagulant.

Definition

ChEBI: Tioclomarol is a hydroxycoumarin.

Manufacturing Process

(a) 1-para-chlorophenyl-3-(5'-chloro-2'-thienyl)-2-propen-1-one - (a) This new compound was prepared in the following manner: 4.4 g of NaOH, in solution in 40 ml of water and 20 ml of ethanol, are cooled to 120°C, and then there are successively added at this temperature 13.2 g (0.086 mol) of para-chloroacetophenone and 12.6 g of 5-chlorothiophene-2- aldehyde. The solution is left standing for 3 hours while stirring at ambient temperature and the precipitate which has formed is centrifuged off, whereafter it is washed with water and recrystallized from alcohol. Yield: 18.4 g, i.e., 75.7% of product, melting at 134°C.
(b) The ketone prepared according to a is condensed at the rate of 14.15 g (0.05 mol) with 8.9 g (0.055 mol) of 4-hydroxycoumarin in 80 ml of water in the presence of 42 mg of hexamethyleneimine. Heating takes place for 4 hours under reflux and, after recrystallization, first of all from a mixture of acetone and water and then from benzene, there are obtained: 12.6 g of 3- (4'-hydroxy-3'-coumarinyl)-3-(5''-chloro-2''-thienyl)-parachloropropiophenone, melting at 162°C (sealed tube).
(b) 4.45 g (0.01 mol) of 3-(4'-hydroxy-3'-coumarinyl)-3-(5''-chloro-2''- thienyl)-parachloropropiophenone, in solution in 75 ml of isopropanol, are reduced with 6.12 g (0.03 mol) of aluminum isopropylate, introduced while stirring and in small quantities at ambient temperature.
The solution is refluxed for one hour and after cooling it is poured into 250 ml of ice and 15 ml of concentrated HCl. On standing, a white precipitate is obtained, which is centrifuged, washed with water, taken up in methanol and filtered. 5 volumes of water are added to this solution, and it is allowed to crystallize at ambient temperature.
The product is analytically pure and shows a pasty fusion at 104°C (sealed tube). Yield: 89%.

Therapeutic Function

Anticoagulant

tioclomarol Preparation Products And Raw materials

Raw materials

Preparation Products

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tioclomarol Suppliers

J & K SCIENTIFIC LTD.
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010-82848833 400-666-7788
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86-10-82849933
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jkinfo@jkchemical.com
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China
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LGM Pharma
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1-(800)-881-8210
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615-250-9817
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inquiries@lgmpharma.com
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United States
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Chemsky (shanghai) International Co.,Ltd
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021-50135380
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shchemsky@sina.com
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China
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Cato Research Chemicals Inc.
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020-81960175
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+1-541-2553641
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min.he@cato-chem.com
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China
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1955
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Shenzhen Polymeri Biochemical Technology Co., Ltd.
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+86-400-002-6226 +86-13028896684;
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sales@rrkchem.com
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China
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Dayang Chem (Hangzhou) Co.,Ltd.
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571-88938639 +8617705817739
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+86-571-88938652,+86-571- 88492614
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info@dycnchem.com
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China
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Energy Chemical
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021-58432009 400-005-6266
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021-58436166
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marketing@energy-chemical.com
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China
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Shaanxi DIDU pharmaceutical and Chemical Co., Ltd
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17691182729 18161915376
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1046@dideu.com
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China
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TargetMol Chemicals Inc.
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4008200310
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marketing@tsbiochem.com
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China
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24647
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TargetMol Chemicals Inc.
Tel
+8613564774135
Email
zijue.cai@tsbiochem.com
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United States
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19885
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22619-35-8, tioclomarolRelated Search:


  • 3-[1-(5-Chloro-2-thienyl)-3-hydroxy-3-(4-chlorophenyl)propyl]-4-hydroxycoumarin
  • tioclomarol
  • 3-[3-(4-Chlorophenyl)-1-(5-chloro-2-thienyl)-3-hydroxypropyl]-4-hydroxy-2H-1-benzopyran-2-one
  • 3-[5-Chloro-α-(p-chloro-β-hydroxyphenethyl)-2-thenyl]-4-hydroxy-couMarin
  • ApegMone
  • 2H-1-Benzopyran-2-one, 3-[3-(4-chlorophenyl)-1-(5-chloro-2-thienyl)-3-hydroxypropyl]-4-hydroxy-
  • 22619-35-8
  • C22H16Cl2O4S
  • Aromatics
  • Heterocycles
  • Intermediates & Fine Chemicals
  • Pharmaceuticals
  • Sulfur & Selenium Compounds