(5alpha)-6,7,8,14-tetradehydro-4,5-epoxy-6-methoxy-17-methylmorphinan-3-ol
- Product Name
- (5alpha)-6,7,8,14-tetradehydro-4,5-epoxy-6-methoxy-17-methylmorphinan-3-ol
- CAS No.
- 467-04-9
- Chemical Name
- (5alpha)-6,7,8,14-tetradehydro-4,5-epoxy-6-methoxy-17-methylmorphinan-3-ol
- Synonyms
- oripavine;Brn 0046094;Einecs 207-385-6;Codeinone Impurity 7;Morphine Sulfate Impurity C;Morphine Sulfate EP Impurity C;Codeine Monohydrate Impurity L;Morphine Hydrochloride Impurity C;Codeine Monohydrate EP Impurity L;Morphine Hydrochloride EP Impurity C
- CBNumber
- CB6905927
- Molecular Formula
- C18H19NO3
- Formula Weight
- 297.35
- MOL File
- 467-04-9.mol
(5alpha)-6,7,8,14-tetradehydro-4,5-epoxy-6-methoxy-17-methylmorphinan-3-ol Property
- Melting point:
- 181-186°C (dec.)
- alpha
- D20 -211.8°
- Boiling point:
- 480.5±45.0 °C(Predicted)
- Density
- 1.38±0.1 g/cm3(Predicted)
- storage temp.
- Controlled Substance, -20°C Freezer
- solubility
- Chloroform (Slightly), Methanol (Slightly)
- form
- Solid
- pka
- 9.28±0.40(Predicted)
- color
- Off-White to Dark Brown
Safety
- RIDADR
- 1544
- HazardClass
- 6.1(b)
- PackingGroup
- III
- Hazardous Substances Data
- 467-04-9(Hazardous Substances Data)
- DEA Controlled Substances
- CSCN: 9330
CSA SCH: Schedule II
NARC: Yes
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H336May cause drowsiness or dizziness
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P271Use only outdoors or in a well-ventilated area.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
N-Bromosuccinimide Price
- Product number
- NMID734B
- Product name
- Oripavine
- Packaging
- 50MG
- Price
- $271
- Updated
- 2023/06/20
(5alpha)-6,7,8,14-tetradehydro-4,5-epoxy-6-methoxy-17-methylmorphinan-3-ol Chemical Properties,Usage,Production
Description
This alkaloid was first obtained from the leaves of Papaver orientalis by moistening the dried leaves with ammonia and extracting them with CH2CI2. Subsequently it has been isolated from P. bracteaturn and on recrystallization from EtOH it forms colourless needles. It is readily soluble in CHCI3, sparingly so in EtOH and Me2CO and insoluble in H20. It is laevorotatory with [α]D - 211.8° (CHC13) and yields a hydrochloride, m.p. 258-9°C (dec.) and a methiodide, m.p. 207-8°C. The alkaloid dissolves in aqueous NaOH yielding a crystalline sodium derivative.
Chemical Properties
Light Tan Solid
Uses
The major metabolite of Thebaine. Oripavine possesses an analgesic potency comparable to Morphine; it is not clinically useful due to severe toxicity and low therapeutic index. An opiate.
Definition
ChEBI: Oripavine is a morphinane alkaloid.
References
Yunusov, Konovalova, Orekhov., Ber., 68,2158 (1935) Yunusov, Konovalova, Orekhov.,J. Gen. Chern. USSR, 10,641 (1940)
Kiselev, Konovalova., ibid, 18,142 (1948)