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ibuproxam

Product Name
ibuproxam
CAS No.
53648-05-8
Chemical Name
ibuproxam
Synonyms
G-277;Ibudros;Nsc305528;ibuproxam;p-Isobutylhydratropohydroxamic acid;2-(4-Isobutylphenyl)propionohydroxamic acid;N-Hydroxy-α-methyl-4-isobutylbenzeneacetamide;N-hydroxy-2-[4-(2-methylpropyl)phenyl]propanamide;Benzeneacetamide, N-hydroxy-α-methyl-4-(2-methylpropyl)-;N-Hydroxy-alpha-methyl-4-(2-methylpropyl)-benzeneacetamide
CBNumber
CB6906085
Molecular Formula
C13H19NO2
Formula Weight
221.29546
MOL File
53648-05-8.mol
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ibuproxam Property

Melting point:
119-121℃
Boiling point:
362.36°C (rough estimate)
Density 
1.058
refractive index 
1.5175 (estimate)
solubility 
Chloroform (Slightly), Methanol (Slightly)
form 
Solid
pka
9.40±0.40(Predicted)
color 
White to Off-White
Water Solubility 
0.2g/L(temperature not stated)
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Safety

Toxicity
LD50 in mice, rats (g/kg): >2, >3 orally (Orzalesi, Selleri, 1978)
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

TRC
Product number
I140200
Product name
racIbuproxam
Packaging
50mg
Price
$545
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
API0011632
Product name
IBUPROXAM
Purity
95.00%
Packaging
100MG
Price
$262.5
Updated
2021/12/16
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ibuproxam Chemical Properties,Usage,Production

Originator

Ibudros,Manetti-Roberts,Italy,1978

Uses

rac Ibuproxam is a poorly water-soluble anti-inflammatory drug.

Definition

ChEBI: A hydroxamic acid obtained by formal condensation of the carboxy group of ibuprofen with the amino group of hydroxylamine. Used for treatment of pain and inflammation associated with musculoskeletal and joint disorders.

Manufacturing Process

In a 1,000 ml three-necked flask equipped with a stirrer, a dropping funnel and a silica gel guard pipe, 46.7 g hydroxylamine hydrochloride are dissolved cold in 480 ml methanol. Separately a solution of 56.1 g KOH in 280 ml methanol is prepared, heated to 30°C and admixed, dropwise under stirring to the hydroxylamine solution. All successive temperature increases during this admixture are prevented by cooling in an ice bath. After the whole KOH solution has been admixed, the mixture is left standing for 5 minutes so as to attain the complete precipitation of the KCl.
Separately, 72.02 g ethyl 2-(4-isobutylphenyl)-propionate, obtained by the esterification of 2-(4-isobutylphenyl)-propionic acid with ethanol and concentrated H2SO4, are solved with 100 ml methanol, this solution is introduced drop by drop into the reaction flask, and stirred and cooled for 5 hours on an ice bath. Thereafter it is suction filtered, the residue is washed with all together 50 ml methanol, the wash is added to the filtrate, thereafter the whole is evaporated in a water bath with a rotating evaporator at a reduced pressure, until 100-200 ml of a concentrated solution are obtained. This solution is poured into a 200 ml beaker into which are stirred approximately 1,000 ml 1.25N acetic acid. This mixture is left standing for 24 hours, thereafter suction filtered. The resulting filtrate is taken up with 100 ml petroleum ether at 40°C to 60°C, in order to solve any possible residue of unreacted starting ester, and refiltered. Approximately 50g of 2-(4- isobutylphenyl)-propiohydroxamic acid are obtained, having a melting point of 119°C to 121°C on Kofler's hot stage.

Therapeutic Function

Antiinflammatory

ibuproxam Preparation Products And Raw materials

Raw materials

Preparation Products

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ibuproxam Suppliers

TargetMol Chemicals Inc.
Tel
+1-781-999-5354 +1-00000000000
Email
marketing@targetmol.com
Country
United States
ProdList
32161
Advantage
58
Energy Chemical
Tel
021-58432009 400-005-6266
Fax
021-58436166
Email
marketing@energy-chemical.com
Country
China
ProdList
44918
Advantage
58
Shaoguan Qicheng Biotechnology Co., Ltd
Tel
18122215013
Email
780229652@qq.com
Country
China
ProdList
1163
Advantage
58
TargetMol Chemicals Inc.
Tel
+8613564774135
Email
zijue.cai@tsbiochem.com
Country
United States
ProdList
19885
Advantage
58

53648-05-8, ibuproxamRelated Search:


  • ibuproxam
  • p-Isobutylhydratropohydroxamic acid
  • G-277
  • Ibudros
  • N-Hydroxy-α-methyl-4-isobutylbenzeneacetamide
  • Nsc305528
  • 2-(4-Isobutylphenyl)propionohydroxamic acid
  • N-Hydroxy-alpha-methyl-4-(2-methylpropyl)-benzeneacetamide
  • N-hydroxy-2-[4-(2-methylpropyl)phenyl]propanamide
  • Benzeneacetamide, N-hydroxy-α-methyl-4-(2-methylpropyl)-
  • 53648-05-8