S-[11beta,17-dihydroxypregn-4-ene-3,20-dione] 21-(thiopivalate)
- Product Name
- S-[11beta,17-dihydroxypregn-4-ene-3,20-dione] 21-(thiopivalate)
- CAS No.
- 55560-96-8
- Chemical Name
- S-[11beta,17-dihydroxypregn-4-ene-3,20-dione] 21-(thiopivalate)
- Synonyms
- JO-1016;Tixocortolpivalate;TIXOCORTOL17PIVALATE;TIXOCORTOL-21PIVALATE;Cortisone Acetate Impurity 2;Tixocortol pivalate Solution, 100μg/mL;S-[11beta,17-dihydroxypregn-4-ene-3,20-dione] 21-(thiopivalate);21-[(2,2-Dimethyl-1-oxopropyl)thio]-11β,17-dihydroxypregn-4-ene-3,20-dione;Pregn-4-ene-3,20-dione, 21-[(2,2-dimethyl-1-oxopropyl)thio]-11,17-dihydroxy-, (11β)-
- CBNumber
- CB6908236
- Molecular Formula
- C26H38O5S
- Formula Weight
- 462.64
- MOL File
- 55560-96-8.mol
S-[11beta,17-dihydroxypregn-4-ene-3,20-dione] 21-(thiopivalate) Property
- Melting point:
- 195-200°
- alpha
- D20 +145° (c = 1 in dioxane)
- storage temp.
- Refrigerator
- solubility
- Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly)
- form
- Solid
- color
- White to Pale Yellow
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H317May cause an allergic skin reaction
H413May cause long lasting harmful effects to aquatic life
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P272Contaminated work clothing should not be allowed out of the workplace.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P321Specific treatment (see … on this label).
P333+P313IF SKIN irritation or rash occurs: Get medical advice/attention.
P363Wash contaminated clothing before reuse.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- T447500
- Product name
- Tixocortol21-Pivalate
- Packaging
- 10mg
- Price
- $175
- Updated
- 2021/12/16
- Product number
- API0015687
- Product name
- TIXOCORTOL PIVALATE
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $504.65
- Updated
- 2021/12/16
- Product number
- API0015687
- Product name
- TIXOCORTOL PIVALATE
- Purity
- 95.00%
- Packaging
- 100MG
- Price
- $2400
- Updated
- 2021/12/16
S-[11beta,17-dihydroxypregn-4-ene-3,20-dione] 21-(thiopivalate) Chemical Properties,Usage,Production
Chemical Properties
Pale Yellow Solid
Originator
Pivalone,Jouveinal,France,1978
Uses
Tixocortol 21-Pivalate is an anti-inflammatory agent. Tixocortol 21-Pivalate is used in fluorescent chemoaffinity labeling.
Uses
Anti-inflammatory. Used in fluorescent chemoaffinity labeling.
Uses
Free thiol in chemoaffinity labeling.
Definition
ChEBI: The pivalate thioester of tixocortol.
Manufacturing Process
In a reactor of 50 liters, sodium S-thiopivalate is prepared from 100 g of S_x0002_thiopivalic acid (0.844 mol), 214 cc of solution of sodium methylate, 3.95 M
(0.844 mol) in 25 liters of anhydrous acetone.
There are then added 285 g (0.603 mol) of dihydroxy-11β,17α-iodo-21-dioxo-
3,20-pregnene-4 and the mixture is brought up to the acetone reflux for two
hours. The solvent is eliminated by distillation under vacuum until there is
obtained a syrupy residue which is poured into 10 liters of iced water. The
insoluble part is filtered and dried under vacuum.
The crude product is purified by recrystallization from ethanol; weight: 250 g;
yield: 89.5%.
Therapeutic Function
Antiinflammatory
Contact allergens
Tixocortol 21-pivalate is a 21-ester of tixocortol, widely used in topical treatments. It can induce severe allergic contact dermatitis. This corticosteroid is a marker of the allergenic A group that includes molecules without major substitution on the D cycle (no C 16 methylation, no C 17 side chain). A short-chain C 21 ester is possible. Molecules are cloprednol, cortisone, fludrocortisone, fluorometholone, hydrocortisone, methylprednisolone, methylprednisone, prednisolone, prednisone, tixocor- tol, and their C 21 esters (acetate, caproate or hexanoate, phosphate, pivalate or trimethylacetate, succinate or hemisuccinate, m-sulfobenzoate).
S-[11beta,17-dihydroxypregn-4-ene-3,20-dione] 21-(thiopivalate) Preparation Products And Raw materials
Raw materials
Preparation Products
S-[11beta,17-dihydroxypregn-4-ene-3,20-dione] 21-(thiopivalate) Suppliers
- Tel
- 18210857532; 18210857532
- Fax
- 86-10-82849933
- jkinfo@jkchemical.com
- Country
- China
- ProdList
- 96815
- Advantage
- 76
- Tel
- 021-50135380
- shchemsky@sina.com
- Country
- China
- ProdList
- 32321
- Advantage
- 50
- Tel
- 0755-0755-66853366 13670046396
- Fax
- 0755-28363542
- sales@chem-strong.com
- Country
- China
- ProdList
- 18333
- Advantage
- 56
- Tel
- 022-6537-8550 15522853686
- Fax
- 022-2532-9655
- sales@altasci.com.cn
- Country
- China
- ProdList
- 4511
- Advantage
- 55
- Tel
- 028-86612776; 13699069380
- Fax
- -
- 515238037@qq.com
- Country
- China
- ProdList
- 968
- Advantage
- 55
- Tel
- +86-400-002-6226 +86-13028896684;
- sales@rrkchem.com
- Country
- China
- ProdList
- 57422
- Advantage
- 58
- Tel
- +1-781-999-5354; +17819995354
- marketing@targetmol.com
- Country
- United States
- ProdList
- 32435
- Advantage
- 58
- Tel
- +1-631-485-4226
- Fax
- 1-631-614-7828
- inquiry@bocsci.com
- Country
- United States
- ProdList
- 19552
- Advantage
- 58
- Tel
- 021-58432009 400-005-6266
- Fax
- 021-58436166
- marketing@energy-chemical.com
- Country
- China
- ProdList
- 44918
- Advantage
- 58
- Tel
- 17717235263
- cindy.yang@lgcgroup.com
- Country
- China
- ProdList
- 18003
- Advantage
- 58