ChemicalBook > CAS DataBase List > 2-(2-thienyl)ethyl toluene-p-sulphonate

2-(2-thienyl)ethyl toluene-p-sulphonate

Product Name: 2-(2-thienyl)ethyl toluene-p-sulphonate
CAS No.: 40412-06-4
Chemical Name: 2-(2-thienyl)ethyl toluene-p-sulphonate
Synonyms: 2-(thiophen-2-yl)ethyl 4-methylbenzenesulfonate;2-Thiopheneethanol Tosylate;200G/1KG/5KGS;2-(Thiophen-2-yl);2-(2-thienyl)ethyl t;Clopidogrel Impurity 32;2-(2-Thienyl)ethyl Tosylate;2-(2-Thiophene)ethanol Tosylate;2-(thiophen-2-yl)ethyl 4-methylbe;2-Thienylethylparatoluene sulphonate
CBNumber: CB6910637
Molecular Formula: C13H14O3S2
Formula Weight: 282.38
MOL File: 40412-06-4.mol

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2-(2-thienyl)ethyl toluene-p-sulphonate Property

Melting point:: 30.0 to 34.0 °C
Boiling point:: 433.2±33.0 °C(Predicted)
Density: 1.280±0.06 g/cm3(Predicted)
vapor pressure: 0-0Pa at 20-25℃
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
solubility: Chloroform (Slightly), Ethyl Acetate (Slightly)
form: Solid
color: Pale Yellow to Pale Brown Low-Melting
InChI: InChI=1S/C13H14O3S2/c1-11-4-6-13(7-5-11)18(14,15)16-9-8-12-3-2-10-17-12/h2-7,10H,8-9H2,1H3
InChIKey: HLPRKWVEMYDPAU-UHFFFAOYSA-N
SMILES: C1=CSC(CCOS(=O)(=O)C2C=CC(C)=CC=2)=C1
LogP: 2.8 at 20℃

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Safety

HS Code: 2934.99.4400

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Hazard statements: H411Toxic to aquatic life with long lasting effects

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N-Bromosuccinimide Price

TCI Chemical

Product number: T3064
Product name: 2-(2-Thienyl)ethyl p-Toluenesulfonate
Purity: >95.0%(GC)
Packaging: 5g
Price: $64
Updated: 2025/07/31

TCI Chemical

Product number: T3064
Product name: 2-(2-Thienyl)ethyl p-Toluenesulfonate
Purity: >95.0%(GC)
Packaging: 25g
Price: $194
Updated: 2025/07/31

TRC

Product number: T344860
Product name: 2-ThiopheneethanolTosylate
Packaging: 1g
Price: $95
Updated: 2021/12/16

AK Scientific

Product number: V2251
Product name: 2-(2-Thienyl)ethyl4-methylbenzenesulfonate
Packaging: 1g
Price: $39
Updated: 2021/12/16

Chem-Impex

Product number: 44227
Product name: 2-(2-Thienyl)ethylp-toluenesulfonate,≥95%(GC)
Purity: ≥95%(GC)
Packaging: 25G
Price: $254.22
Updated: 2021/12/16

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2-(2-thienyl)ethyl toluene-p-sulphonate Chemical Properties,Usage,Production

Chemical Properties

Off-White Solid

Uses

2-(2-thienyl)ethyl toluene-p-sulphonate is an important intermediate of the synthetic drug clopidogrel. Clopidogrel is a new and effective medicament for resisting platelet aggregation. Clinically, it is widely used in the treatment and prevention of myocardial infarction, cardiovascular and cerebrovascular diseases, etc.

Uses

Intermediate in the preparation of Rotigotine

Synthesis

5402-55-1

98-59-9

40412-06-4

GENERAL STEPS: 2-Thiophene ethanol (0.87 mol) and p-toluenesulfonyl chloride (184 g, 0.97 mol) were added sequentially to a 1 L three-necked flask. Under the condition of ice-water bath, triethylamine (98 g, 0.97 mol) was slowly added dropwise and the temperature of the reaction solution was controlled not to exceed 20 °C. The reaction system was then purified by the reaction of the reaction solution. After the dropwise addition, the reaction system was heated to 35 °C with continuous stirring. Samples were taken after 24 h and 27 h, respectively, and the progress of the reaction was monitored by thin layer chromatography (TLC) until the reaction was complete. After completion of the reaction, heating was stopped and filtration was carried out. The filter cake was washed with appropriate amount of dichloromethane, the organic layers were combined and dried with anhydrous sodium sulfate for 2 hours. The desiccant was removed by filtration and the desiccant was washed with a small amount of dichloromethane. The combined filtrates were concentrated under reduced pressure until constant weight to give the brown oily product 2-thiophene ethanol p-toluenesulfonate (203 g, 98% yield).

References

[1] Patent: CN103467486, 2016, B. Location in patent: Paragraph 0094-0096
[2] Patent: US2007/225320, 2007, A1. Location in patent: Page/Page column 5
[3] Patent: CN107056801, 2017, A. Location in patent: Paragraph 0016
[4] Patent: US2007/225320, 2007, A1. Location in patent: Page/Page column 7
[5] Patent: WO2011/161255, 2011, A2. Location in patent: Page/Page column 36

2-(2-thienyl)ethyl toluene-p-sulphonate Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 2-(2-thienyl)ethyl toluene-p-sulphonate manufacturers

Jinan Ruitong Biotech Co., Ltd.

Product: 2-(Thiophen-2-yl)ethyl 4-methylbenzenesulfonate 40412-06-4
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 1
Release date: 2025-08-27

WUHAN FORTUNA CHEMICAL CO., LTD

Product: 2-(2-thienyl)ethyl toluene-p-sulphonate 40412-06-4
Price: US $0.00/KG
Min. Order: 1KG
Purity: 98%min
Supply Ability: 30tons/month
Release date: 2023-01-31

Hebei Chuanghai Biotechnology Co., Ltd

Product: 2-(2-thienyl)ethyl toluene-p-sulphonate 40412-06-4
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 10 mt
Release date: 2024-11-22

40412-06-4, 2-(2-thienyl)ethyl toluene-p-sulphonateRelated Search:

AMINO-(3-CHLORO-PHENYL)-ACETIC ACID DL-Chlorophenylglycine methyl ester hydrochloride (+)METHYL ALPHA-(2-THIENYLETHYLAMINO)(2-CHLOROPHENYL)ACETATE HCL Clopidogrel Impurity 18 Clopidogrel Impurity 16 Clopidogrel Impurity 24 DL-2-(2-Chlorophenyl)glycine DL-4-Chlorophenylglycine Clopidogrel Impurity 17 Clopidogrel Impurity 23 1-(4-CHLOROPHENYL)-2-METHOXY-2-OXO-1-ETHANAMINIUM CHLORIDE N-(2-CHLOROBENZYL)-2-(2-THIENYL)ETHYLAMINE HYDROCHLORIDE 2-Amino-2-phenylacetic acid Clopidogrel Impurity 20 p-Toluenesulfonic acid 2-(2-thienyl)ethyl toluene-p-sulphonate (4-Thien-2-yltetrahydro-2H-pyran-4-yl)methyl 4-methylphenylsulphonate 97% 2-(2-thienyl)ethyl methanesulphonate

2-Thiopheneethanol Tosylate

2-(thiophen-2-yl)ethyl 4-methylbenzenesulfonate

4-Methylbenzenesulfonic acid 2-(2-thienyl)ethyl ester

2-(2-Thienyl)ethyl 4-methylbenzenesulfonate

2-(2-thienyl)ethyl toluene-p-sulphonate

2-(2-thienyl)ethyl-4-Methybenzenesulfonate

4-Methyl-3-[2-(thiophen-2-yl)ethyl]benzene-1-sulfonate

2-(2-Thienyl)ethyl Toluene-p-sulfonate

2-(2-Thienyl)ethyl Tosylate

2-(2-Thiophene)ethanol Tosylate

2-(Thien-2-yl)ethyl 4-Methylbenzenesulfonate

2-Thiopheneethanol 2-(4-Methylbenzenesulfonate)

200G/1KG/5KGS

2-Thiophene-ethanol-4-Methyl-benzene sulfonate

2-(2-thienyl)ethyl t

2-Thiopheneethanol,4-Methylbenzenesulfonate (9CI)

2-(2-Thienyl)ethyl p-Toluenesulfonate

Toluene-4-sulfonicacid thiophene-2-yl-ethylester

2-(Thiophen-2-yl)

2-(thiophen-2-yl)ethyl 4-methylbe

Clopidogrel Impurity 32

p-Toluenesulfonic Acid 2-(2-Thienyl)ethyl Ester

2-(2-thiophene) ethanol p-toluenesulfonate

2-Thienylethylparatoluene sulphonate

TIANFU-CHEM - 2-(2-thienyl)ethyl toluene-p-sulphonate

S-(+)-Methyl-(2-Chlorophenyl)[2-(2-Thienyl) Amino] Hydrochlorid

2-(thiophen-2-yl) ethyl p-toluenesulfonate

2-(Thiophen-2-yl)methylp-toluenesulfonate

40412-06-4

INTERMEDIATES OF CLOPIDOGREL

Aromatics

Intermediates

Sulfur & Selenium Compounds