Silane, dichlorodimethyl-, reaction products with silica
- Product Name
- Silane, dichlorodimethyl-, reaction products with silica
- CAS No.
- 68611-44-9
- Chemical Name
- Silane, dichlorodimethyl-, reaction products with silica
- Synonyms
- DICHLOROMETHYLSILANE,REACTIONPRODUCTWITHSILICA;DIMETHYLDICHLOROSILANE, REACTION PRODUCTS WITH SILICA;Silane, dichlorodimethyl-, reaction products with silica
- CBNumber
- CB6922694
- Molecular Formula
- C2H6Cl2O2Si2
- Formula Weight
- 189.14
- MOL File
- 68611-44-9.mol
Silane, dichlorodimethyl-, reaction products with silica Property
- Density
- 0.18 g/cm 3 (loose weight)(lit.)
- solubility
- Solubility is 1 in 6.7 parts of water (pH 7, 25°C). Practically insoluble in organic solvents(5) and acids, except hydrofluoric acid; soluble in hot solutions of alkali hydroxide.
- EPA Substance Registry System
- Silane, dichlorodimethyl-, reaction products with silica (68611-44-9)
Safety
- Hazard Codes
- Xn,T
- Risk Statements
- 48/20-36/37-49
- Safety Statements
- 53-22-26-45
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H330Fatal if inhaled
- Precautionary statements
-
P260Do not breathe dust/fume/gas/mist/vapours/spray.
P271Use only outdoors or in a well-ventilated area.
P284Wear respiratory protection.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P310Immediately call a POISON CENTER or doctor/physician.
P320Specific treatment is urgent (see … on this label).
P403+P233Store in a well-ventilated place. Keep container tightly closed.
P405Store locked up.
P501Dispose of contents/container to..…
Silane, dichlorodimethyl-, reaction products with silica Chemical Properties,Usage,Production
Chemical Properties
Hydrophobic colloidal silica occurs as a light, fine, white or almost white amorphous powder, not wettable by water.
Production Methods
Hydrophobic colloidal silica is prepared by the flame hydrolysis of chlorosilanes, such as silicon tetrachloride, at 1800°C using a hydrogen–oxygen flame. It is rapidly cooled to create an amorphous productand immediately treated with dichlorodimethyl silane in a fluid bed reactor. The resulting surface is covered with dimethylsilyl groups. Aerosil R972 is manufactured by modifying the surface of Aerosil 130 and thus has the same primary particle size and surface area, but the density of silanol groups is reduced from approximately 2.0 SiOH/nm2 to 0.75 SiOH/nm2.
Pharmaceutical Applications
large specific surface area, which provide desirable flow
characteristics in dry powders used in tableting and capsule
filling. The hydrophobic grades absorb less moistureand may
offer an advantage in moisture-sensitive formulations.
Hydrophobic colloidal silica is also used to thixotropically
control viscosity, to thicken and stabilize emulsions, or as a
suspending agent in gels and semisolid preparations. Hydrophobic
colloidal silica has a less pronounced effect on solution viscosity but
can thicken and stabilize the oil phase of a water–oil emulsion.
With other ingredients of similar refractive index, transparent gels
may be formed. Generally, the uses and ranges of hydrophobic
colloidal silica are similar to the concentrations used of the standard
hydrophilic colloidal silicon dioxide.
Safety
The safety profile of hydrophobic colloidal silica is the same as for
the hydrophilic silica types, as the modified silica surface does not
significantly alter the toxicological properties.
LD50 (rat, IV): 0.015 g/kg
storage
Hydrophobic colloidal silica should be stored in a well-closed container. It will not absorb moisture but may still absorb volatile substances owing to its high surface area.
Incompatibilities
Use of the hydrophobic colloidal silica Aerosil R972 reduces the strength of starch-based tablets.
Regulatory Status
Approved for use in pharmaceuticals in Europe. Approved by FDA and Europe for food contact articles. Included in nonparenteral medicines (oral tablets; rectal suppositories) licensed in the UK.
Silane, dichlorodimethyl-, reaction products with silica Preparation Products And Raw materials
Raw materials
Preparation Products
Silane, dichlorodimethyl-, reaction products with silica Suppliers
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View Lastest Price from Silane, dichlorodimethyl-, reaction products with silica manufacturers
- Product
- Polyquaternium-37 68611-44-9
- Price
- US $10.00-5.00/kg
- Min. Order
- 1kg
- Purity
- 99.5
- Supply Ability
- 10 ton per month
- Release date
- 2023-11-28
- Product
- silica dimethyl silylate 68611-44-9
- Price
- US $10.00/kg
- Min. Order
- 1kg
- Purity
- 99.99%
- Supply Ability
- 1000000000 ton
- Release date
- 2024-04-16
- Product
- Silica Dimethyl Silylate 68611-44-9
- Price
- US $18.00-18.00/kg
- Min. Order
- 1kg
- Purity
- 99.9
- Supply Ability
- 5000
- Release date
- 2024-05-11