fenproporex Property

Boiling point:

bp2 126-127°

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H301Toxic if swalloed

H312Harmful in contact with skin

H315Causes skin irritation

H319Causes serious eye irritation

H331Toxic if inhaled

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P311Call a POISON CENTER or doctor/physician.

P312Call a POISON CENTER or doctor/physician if you feel unwell.

P321Specific treatment (see … on this label).

P322Specific measures (see …on this label).

P330Rinse mouth.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

P363Wash contaminated clothing before reuse.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

P405Store locked up.

P501Dispose of contents/container to..…

fenproporex Chemical Properties,Usage,Production

Originator

Fenproporex,Chephasaar,W. Germany,1975

Definition

ChEBI: Fenproporex is a member of amphetamines.

Manufacturing Process

(a) 22 g of acrylonitrile and 27 g of racemic α-methyl-β-phenylethylamine were introduced into a 100 ml round-bottomed flask and left standing for 13 hours at ambient temperature, and then the mixture was boiled under reflux for 12? hours. The excess acrylonitrile was then evaporated in vacuo and the residue distilled. 27.3 g (yield: 72.6%) of racemic N-(β-cyanoethyl)-α-methyl- β-phenylethylamine were obtained as an oily liquid, BP = 126°C to 127°C/2 mm Hg.
(b) 22 g of the base obtained in (a) were dissolved in 80 ml of anhydrous diethyl ether and an ethereal solution of hydrochloric acid added until the pH value was 1. The salt was filtered off, dried and washed with 10 ml of diethyl ether. 18 g (yield: 68%) of N-(β-cyanoethyl-α-methyl-β-phenylethylamine hydrochloride were obtained, after recrystallization from absolute ethanol, as a white, microcrystalline, odorless powder having a bitter, acid taste; it was fairly soluble in water, ether and benzene. MP = 146°C on a Kofler block.

Therapeutic Function

Anorexic