sodium 5-(sec-butyl)-5-ethylbarbiturate Property

Melting point:

The free acid mp 165-168°

EPA Substance Registry System

Butabarbital sodium (143-81-7)

Safety

RIDADR 

3249

HazardClass 

6.1(b)

PackingGroup 

III

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H301Toxic if swalloed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

P321Specific treatment (see … on this label).

P330Rinse mouth.

P405Store locked up.

P501Dispose of contents/container to..…

sodium 5-(sec-butyl)-5-ethylbarbiturate Chemical Properties,Usage,Production

Originator

Butisol sodium,Wallace Labs,USA

Uses

Sedative-hypnotic.

Manufacturing Process

5-sec-Butyl-5-ethylbarbituric acid was prepared from diethyl ester of malonic acid in 3 steps. At the above malonic ester was reacted with C2H5Br and sodium ethylate producing the diethyl ester of ethylmalonic acid, which after a reaction with sodium ethylate and 2-butylbromide gave the ethyl-(2-butyl)- malonic acid diethyl ester. The last one produced the 5-sec-butyl-5-ethylbarbituric acid after a reaction with urea and sodium ethylate.
23 g sodium (1 mol) was dissolved in 300 ml alcohol. To this solution was added a solution of 5-sec-butyl-5-ethyl-barbituric acid (1 mol) in 800 ml alcohol. To a mixture was added 1000 ml benzene, which precipitated the sodium salt of the barbituric acid (butabarbital sodium). The product was filtered and dried.

brand name

Butabarb (Alpharma); Butalan (Lannett); Buticaps (Medpointe); Butisol Sodium (Medpointe); Sarisol (Halsey).

Therapeutic Function

Hypnotic