hydrocotarnine

Product Name: hydrocotarnine
CAS No.: 550-10-7
Chemical Name: hydrocotarnine
Synonyms: 8-Methoxy-2-methyl-6,7-methylenedioxy-1,2,3,4-tetrahydroisoquinoline;Hydrocotarnine Hydrochloride;hydrocotarnine, 10 mM in DMSO;Noscapine Impurity 3(Hydrocotarnine);4-methoxy-6-methyl-2H,5H,6H,7H,8H-[1,3]dioxolo[4,5-g]isoquinoline;5,6,7,8-Tetrahydro-4-methoxy-6-methyl-1,3-dioxolo[4,5-g]isoquinoline;4-Methoxy-6-methyl-5,6,7,8-tetrahydro-1,3-dioxolo[4,5-g]isoquinoline;1,3-Dioxolo[4,5-g]isoquinoline, 5,6,7,8-tetrahydro-4-methoxy-6-methyl-;1,2,3,4-Tetrahydro-2-methyl-6,7-(methylenebisoxy)-8-methoxyisoquinoline;4-methoxy-6-methyl-7,8-dihydro-5H-[1,3]dioxolo[4,5-g]isoquinoline hydrate hydrochloride
CBNumber: CB6930118
Molecular Formula: C12H15NO3
Formula Weight: 221.25
MOL File: 550-10-7.mol

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hydrocotarnine Property

Melting point:: 56°C
Boiling point:: 362.31°C (rough estimate)
Density: 1.1514 (rough estimate)
refractive index: 1.5200 (estimate)
solubility: Chloroform (Slightly), Ethyl Acetate (Slightly)
form: Solid
pka: 7.75±0.20(Predicted)
color: Light Brown to Orange

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

TRC

Product number: TRC-M543560-50MG
Product name: 4-Methoxy-6-methyl-5,6,7,8-tetrahydro-[1,3]dioxolo[4,5-g]isoquinoline
Packaging: 50mg
Price: $256
Updated: 2026/06/03

TRC

Product number: TRC-M543560-10MG
Product name: 4-Methoxy-6-methyl-5,6,7,8-tetrahydro-[1,3]dioxolo[4,5-g]isoquinoline
Packaging: 10mg
Price: $66
Updated: 2026/06/03

TRC

Product number: TRC-M543560-100MG
Product name: 4-Methoxy-6-methyl-5,6,7,8-tetrahydro-[1,3]dioxolo[4,5-g]isoquinoline
Packaging: 100mg
Price: $409
Updated: 2026/06/03

Biosynth

Product number: AAA55010
Product name: 4-Methoxy-6-methyl-2H,5H,6H,7H,8H-[1,3]dioxolo[4,5-G]isoquinoline
Packaging: 25mg
Price: $189
Updated: 2026/06/04

Biosynth

Product number: AAA55010
Product name: 4-Methoxy-6-methyl-2H,5H,6H,7H,8H-[1,3]dioxolo[4,5-G]isoquinoline
Packaging: 50mg
Price: $302.5
Updated: 2026/06/04

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hydrocotarnine Chemical Properties,Usage,Production

Uses

Hydrocotarnine Hydrochloride, is an oxidative degradation product of the drug Noscapine (128-62-1).

Definition

ChEBI: 4-methoxy-6-methyl-7,8-dihydro-5H-[1,3]dioxolo[4,5-g]isoquinoline is a member of isoquinolines.

in vivo

Hydrocotarnine (10 mg/kg/d; i.p.; 9 d) shows inhibitory effect on Cbl and results in increasing IL-18 levels, indicating that NLRP3 inflammasome activation is enhanced in mice^[1].
Hydrocotarnine (10 mg/kg/d; i.p.; 9 d) protects mice from DSS-induced colitis, with low scores of pathological evaluation of inflammation, epithelial defects, and crypt atrophy^[1].

Animal Model:	DSS-induced colitis model in C57BL/6 mice (6-9 weeks old)^[1]
Dosage:	10 mg/kg
Administration:	Intraperitoneal injection; once daily; 9 days while 2.5% DSS treatment began on day 1 and ended on day 7
Result:	Significantly attenuated the weight loss of DSS-induced colitis mice compared to PBS-treated control mice, indicating that decreasing negative regulation of the NLRP3 inflammasome activation could attenuate colitis in an animal model.

hydrocotarnine Preparation Products And Raw materials

Raw materials

Preparation Products

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hydrocotarnine Suppliers

China 21 India 1 United Kingdom 1 United States 5 Global 28

Shanghai Topbiochem Technology Co., Ltd

Tel: 021-58170097
Email: info@topbiochem.com
Country: China
ProdList: 9520
Advantage: 58

Shanghai YuanYe Biotechnology Co., Ltd.

Tel: 021-61312847; 18021002903
Fax: QQ:3008007432
Email: 3008007409@qq.com
Country: China
ProdList: 89686
Advantage: 60

Changzhou Hopschain Chemical Co.,Ltd.

Tel: 85528066 13775048983
Fax: 0519-85528066
Email: sales@hopschem.com
Country: China
ProdList: 31553
Advantage: 55

TargetMol Chemicals Inc.

Tel: +1-781-999-5354; +17819995354
Email: marketing@targetmol.com
Country: United States
ProdList: 32466
Advantage: 58

Shanghai Haohong Pharmaceutical Co., Ltd.

Tel: 400-8210725 4008210725
Email: malulu@leyan.com
Country: China
ProdList: 54995
Advantage: 58

Nantong Hi-Future Biotechnology Co., Ltd

Tel: 18051384581
Email: sales@chemhifuture.com
Country: China
ProdList: 2987
Advantage: 58

Shaanxi DIDU pharmaceutical and Chemical Co., Ltd

Tel: 029-029-81120477 17792793610
Email: 1033@dideu.com
Country: China
ProdList: 9996
Advantage: 58

TargetMol Chemicals Inc.

Tel: 4008200310 15002144251
Email: marketing@tsbiochem.com
Country: China
ProdList: 24955
Advantage: 58

Shanghai Yifei Biotechnology Co. , Ltd.

Tel: 021-65675885 18964387627
Email: customer_service@efebio.com
Country: China
ProdList: 11972
Advantage: 58

Shanghai?Medlife?Pharm-Tech?Co.,?Ltd

Tel: 021-59167510 18117107507
Email: vip@med-life.cn
Country: China
ProdList: 5001
Advantage: 58

550-10-7, hydrocotarnineRelated Search:

8-Methoxyisoquinoline

1,2,3,4-Tetrahydro-2-methyl-6,7-(methylenebisoxy)-8-methoxyisoquinoline

4-Methoxy-6-methyl-5,6,7,8-tetrahydro-1,3-dioxolo[4,5-g]isoquinoline

5,6,7,8-Tetrahydro-4-methoxy-6-methyl-1,3-dioxolo[4,5-g]isoquinoline

Hydrocotarnine Hydrochloride

4-methoxy-6-methyl-7,8-dihydro-5H-[1,3]dioxolo[4,5-g]isoquinoline hydrate hydrochloride

4-methoxy-6-methyl-2H,5H,6H,7H,8H-[1,3]dioxolo[4,5-g]isoquinoline

Noscapine Impurity 3(Hydrocotarnine)

1,3-Dioxolo[4,5-g]isoquinoline, 5,6,7,8-tetrahydro-4-methoxy-6-methyl-

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hydrocotarnine, 10 mM in DMSO

8-Methoxy-2-methyl-6,7-methylenedioxy-1,2,3,4-tetrahydroisoquinoline

550-10-7