(Z)-4-[3-(2-chloro-9H-thioxanthen-9-ylidene)propyl]piperazine-1-ethanol dihydrochloride Property

Melting point:

250-260° (dec)

Safety

Toxicity

LD50 in male mice (mg/kg): 105 i.v. (Lassen)

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P330Rinse mouth.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

P501Dispose of contents/container to..…

(Z)-4-[3-(2-chloro-9H-thioxanthen-9-ylidene)propyl]piperazine-1-ethanol dihydrochloride Chemical Properties,Usage,Production

Originator

Zuclopenthixol Hydrochloride,ZYF Pharm Chemical

Manufacturing Process

288.0 g of 2-chloro-9-allylthiaxanthenol-(9), melting at 77-78°C, are prepared by adding 2-chloro-thiaxanthone to an ether solution of allyl magnesium bromide followed by hydrolysis.
The 2-chloro-9-allylthiaxanthenol-(9) is dissolved in 2 L of anhydrous ether, whereafter 360.0 g triethylamine are added. While stirring and cooling, 150.0 g thionyl chloride dissolved in 500 ml ether are added gradually, allowing the temperature to rise to a maximum of -10°C. After completion of addition, the ether solution is shaken 3 times with ice water, each time with 0.3 L, whereafter it is dried with potassium carbonate. Thereafter, the ether is evaporated in vacuum and the 2-chloro-9-(propene-3-ylidene-1)-thiaxanthene formed is obtained as a light yellow syrup.
2 methods of producing of 2-chloro-9-[3'-(N'-2-hydroxyethylpiperazino- N)propylidene]thiaxanthene from 2-chloro-9-(propene-3-ylidene-1) thiaxanthene:
1). 27.0 g of 2-chloro-9-(propene-3-ylidene-1)thiaxanthene, are mixed with 50.0 g anhydrous piperazine and 10 ml absolute ethanol and the mixture is heated for 12 h at 120°C under reflux. After cooling, the solidified reaction mixture is treated with 500 ml of water and the mixture extracted with ether. From the ether solution, the 2-chloro-9-(3'-N-piperazino)propylidene) thiaxanthene formed is extracted with dilute hydrochloric acid and precipitated as the base from the aqueous solution by rendering the solution alkaline. By extraction with ether, drying of the ether solution with potassium carbonate and evaporation of the ether, the free base 2-chloro-9-(3'-N-piperazino) propylidene)thiaxanthene is obtained as a colorless oil in a yield of 21.0 g.
35.0 g of the base 2-chloro-9-(3'-N-piperazino)propylidene)thiaxanthene are dissolved in 200 ml of methanol. 5.0 g ethylene oxide are added and the mixture is left standing at room temperature for 3 h. Thereafter, the reaction mixture is evaporated, dried and the 2-chloro-9-[3'-(N'-2- hydroxyethylpiperazino-N)propylidene]thiaxanthene is obtained.
2). 27.0 g of 2-chloro-9-(propene-3-ylidene-1)thiaxanthene, are mixed with 50.0 g anhydrous N-2-hydroxyethylpiperazine and 10 ml absolute ethanol and the mixture is heated for 12 h at 120°C under reflux. After cooling, the solidified reaction mixture is treated with 500 ml of water and the mixture extracted with chloroform. From the chloroform solution, the 2-chloro-9-[3'- (N'-2-hydroxyethylpiperazino-N)-propylidene]thiaxanthene formed is extracted with dilute hydrochloric acid and precipitated as the base from the aqueous solution by rendering the solution alkaline. By extraction with chloroform, drying of the organic solution with potassium carbonate and evaporation of the chloroform, the base 2-chloro-9-[3'-(N'-2-hydroxyethylpiperazino- N)propylidene]thiaxanthene is obtained as colorless syrup. By dissolving the base in petrol and leaving the solution to stand the trans form crystallize out as a white crystalline substance, from the mother liquor from the trans base, the corresponding cis base can be obtained as a white crystalline substance.
In practice it is usually used as dihydrochloride.

Therapeutic Function

Neuroleptic, Antipsychotic