Epothilone A

Product Name: Epothilone A
CAS No.: 152044-53-6
Chemical Name: Epothilone A
Synonyms: CS-555;CS-1899;Epothile;Ebomycin A;Epothilon A;Epothilone-S;EPOTHILONE A;(-)-EPOTHILONE A;epothile|||Epo A;Epothilone A (Epo A)
CBNumber: CB6972280
Molecular Formula: C26H39NO6S
Formula Weight: 493.66
MOL File: 152044-53-6.mol

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Epothilone A Property

Melting point:: 95℃
alpha: D21 -47.1° (c = 1.0 in methanol)
Boiling point:: 683.3±55.0 °C(Predicted)
Density: 1.143
storage temp.: -20°C
solubility: Chloroform (Slightly), Ethyl Acetate (Slightly)
form: solid
pka: 13.57±0.70(Predicted)
color: White to Off-White
Stability:: Stable under recommended storage conditions., Stable Under Recommended Storage C
InChIKey: HESCAJZNRMSMJG-KKQRBIROSA-N
SMILES: [C@]12([H])[C@]([H])(O1)CCC[C@H](C)[C@H](O)[C@@H](C)C(=O)C(C)(C)[C@@H](O)CC(=O)O[C@H](/C(/C)=C/C1=CSC(C)=N1)C2

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Safety

WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: E3656
Product name: (?)-Epothilone A
Purity: fromSorangiumcellulosum,>95%(HPLC),solid
Packaging: 10μg
Price: $102
Updated: 2024/03/01

Cayman Chemical

Product number: 16482
Product name: Epothilone A
Purity: ≥95%
Packaging: 1mg
Price: $44
Updated: 2024/03/01

Cayman Chemical

Product number: 16482
Product name: Epothilone A
Purity: ≥95%
Packaging: 5mg
Price: $118
Updated: 2024/03/01

Cayman Chemical

Product number: 16482
Product name: Epothilone A
Purity: ≥95%
Packaging: 10mg
Price: $214
Updated: 2024/03/01

Usbiological

Product number: E3428-74
Product name: Epothilone A
Packaging: 100ug
Price: $513
Updated: 2021/12/16

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Epothilone A Chemical Properties,Usage,Production

Uses

The epothilones are a novel class of antineoplastic agents possessing antitubulin activity. Epothilone A, B isolated from Sorangium cellulosum was associated with cell cycle arrest at G2/M transition and apoptosis that was resisted with overexpression of β-tubulin and P-glycoprotein in human bladder carcinoma cell.

Uses

Epothilone A is a microtubule inhibitor isolated from the myxobacteria, Sorangium cellulosum. Epothilone A acts by stabilising microtubule formation at the taxol binding site, and causes cell cycle arrest at the G2/M transition, leading to cytotoxicity. Epothilone A has been investigated in clinical trials as an antitumour agent.

Definition

ChEBI: An epithilone that is epothilone C in which the double bond in the macrocyclic lactone ring has been oxidised to the corresponding epoxide (the 13R,14S diastereoisomer).

Biological Activity

epothilone a (epo a) is a naturally occurring microtubule-stabilizing macrolide that was first isolated from the myxobacterium sorangium cellulosum. the ic50 value of epothilone a in hct-116 cell line is 4.4 nm [1].it has been found that the skov-3 human ovarian cancer cells were susceptible to epothilone a with ic50 value of 20.4 ± 1.4 nm [2]. the antiproliferative capacity of epothilone a in skov-3 cell line (measured as ic50 after 72 h continuous treatment) was six times greater than that of ptx’s. besides, epothilone a induced time coursedependent apoptosis and necrosis [2].

target

MDR CCRF-CEM/VBL100 cells

References

[1] regueiro-ren a1, borzilleri rm, zheng x, kim sh, johnson ja, fairchild cr, lee fy, long bh, vite gd. synthesis and biological activity of novel epothilone aziridines. org lett. 2001 aug 23;3(17):2693-6.
[2] rogalska a1, marczak a, gajek a, szwed m, śliwińska a, drzewoski j, jóźwiak z. induction of apoptosis in human ovarian cancer cells by new anticancer compounds, epothilone a and b. toxicol in vitro. 2013 feb;27(1):239-49.

Epothilone A Preparation Products And Raw materials

Raw materials

Preparation Products

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Epothilone A Suppliers

Canada 1 China 110 Germany 1 India 1 Switzerland 1 United Kingdom 1 United States 19 Global 134

LGM Pharma

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View Lastest Price from Epothilone A manufacturers

Qiuxian Baitai New Material Co., LTD

Product: Epothilone A 152044-53-6
Price: US $10.00/g
Min. Order: 1KG
Purity: 99%
Supply Ability: 5ton/Month
Release date: 2021-11-24

Shaanxi Dideu Medichem Co. Ltd

Product: Epothilone A 152044-53-6
Price: US $0.00-0.00/Kg
Min. Order: 1KG
Purity: 99.0%
Supply Ability: 800 ton
Release date: 2020-04-30

Career Henan Chemical Co

Product: Epothilone A 152044-53-6
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 100kg
Release date: 2019-07-09

152044-53-6, Epothilone ARelated Search:

Amphotericin B (1S,3S,7S,10R,11S,12S,16R)-3-[(1E)-2-[2-(Aminomethyl)-4-thiazolyl]-1-methylethenyl]-7,11-dihydroxy-8,8,10,12,16-pentamethyl-4,17-dioxabicyclo[14.1.0]heptadecane-5,9-dione Epothilone B Oxacyclohexadec-13-ene-2,6-dione, 4,8-dihydroxy-5,5,7,9-tetramethyl-16-(1E)-1-methyl-2-(2-methyl-4-thiazolyl)ethenyl-, (4S,7R,8S,9S,13Z,16S)- Epothilone D epothilone E ALLYL MYRISTATE Cyclopentadecanolide Epothilone A

4,17-Dioxabicyclo14.1.0heptadecane-5,9-dione, 7,11-dihydroxy-8,8,10,12-tetramethyl-3-(1E)-1-methyl-2-(2-methyl-4-thiazolyl)ethenyl-, (1S,3S,7S,10R,11S,12S,16R)-

Epothilone-S

(1S,3S,7S,10R,11S,12S,16R)-7,11-Dihydroxy-8,8,10,12-tetramethyl-3-[(1E)-1-methyl-2-(2-methyl-4-thiazolyl)ethenyl]-4,17-dioxabicyclo[14.1.0]heptadecane-5,9-dione

Epothile

4,17-Dioxabicyclo[14.1.0]heptadecane-5,9-dione,7,11-dihydroxy-8,8,10,12-tetraMethyl-3- [(1E)-1-Methy

Ixabepilone Impurity 5 (Epothilone A)

(1S,3S,7S,10R,11S,12S,16R,E)-7,11-dihydroxy-8,8,10,12-tetramethyl-3-(1-(2-methylthiazol-4-yl)prop-1-en-2-yl)-4,17-dioxa-bicyclo[14.1.0]heptadecane-5,9-dione

(1S,3S,7S,10R,11S,12S,16R)-7,11-Dihydroxy-8,8,10,12-tetramethyl-3-[(1E)-1-methyl-2-(2-methyl-4-thiazolyl)ethenyl]-4,17-dioxabicyclo[14.1.0]heptadecane-5,9-dione Epothilone A

Epothilone A (1S,3S,7S,10R,11S,12S,16R)-7,11-Dihydroxy-8,8,10,12-tetramethyl-3-[(1E)-1-methyl-2-(2-methyl-4-thiazolyl)ethenyl]-4,17-dioxabicyclo[14.1.0]heptadecane-5,9-dione

4,17-Dioxabicyclo[14.1.0]heptadecane-5,9-dione,7,11-dihydroxy-8,8,10,12-tetramethyl-3- [(1E)-1-methyl-2-(2-methyl-4-thiazolyl)- ethenyl]-,(1R,3R,7R,10S,11R,12R,16S)-rel-

CS-1899

CS-555

Ixabepilone Impurity 5

EPOTHILONE A

(-)-EPOTHILONE A

Epothilon A

Epothilone A USP/EP/BP

(1S,3S,7S,10R,11S,12S,16R)-7,11-Dihydroxy-8,8,10,12-tetramethyl-3-((E)-1-(2-methylthiazol-4-yl)prop-1-en-2-yl)-4,17-dioxabicyclo[14.1.0]heptadecane-5,9-dione

Epothilone A (Epo A)

Ebomycin A

epothile|||Epo A

152044-53-6

C26H39NO6S

Chiral Reagents

Inhibitors

Intermediates & Fine Chemicals

Pharmaceuticals

Sulfur & Selenium Compounds